6FVL
DNA polymerase sliding clamp from Escherichia coli with bound P7 peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006260 | biological_process | DNA replication |
| A | 0006261 | biological_process | DNA-templated DNA replication |
| A | 0006271 | biological_process | DNA strand elongation involved in DNA replication |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0009360 | cellular_component | DNA polymerase III complex |
| A | 0030174 | biological_process | regulation of DNA-templated DNA replication initiation |
| A | 0030894 | cellular_component | replisome |
| A | 0032297 | biological_process | negative regulation of DNA-templated DNA replication initiation |
| A | 0042276 | biological_process | error-prone translesion synthesis |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0044787 | biological_process | bacterial-type DNA replication |
| A | 1990078 | cellular_component | replication inhibiting complex |
| A | 1990085 | cellular_component | Hda-beta clamp complex |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006260 | biological_process | DNA replication |
| B | 0006261 | biological_process | DNA-templated DNA replication |
| B | 0006271 | biological_process | DNA strand elongation involved in DNA replication |
| B | 0006974 | biological_process | DNA damage response |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0009360 | cellular_component | DNA polymerase III complex |
| B | 0030174 | biological_process | regulation of DNA-templated DNA replication initiation |
| B | 0030894 | cellular_component | replisome |
| B | 0032297 | biological_process | negative regulation of DNA-templated DNA replication initiation |
| B | 0042276 | biological_process | error-prone translesion synthesis |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0044787 | biological_process | bacterial-type DNA replication |
| B | 1990078 | cellular_component | replication inhibiting complex |
| B | 1990085 | cellular_component | Hda-beta clamp complex |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006260 | biological_process | DNA replication |
| C | 0006261 | biological_process | DNA-templated DNA replication |
| C | 0006271 | biological_process | DNA strand elongation involved in DNA replication |
| C | 0006974 | biological_process | DNA damage response |
| C | 0008408 | molecular_function | 3'-5' exonuclease activity |
| C | 0009360 | cellular_component | DNA polymerase III complex |
| C | 0030174 | biological_process | regulation of DNA-templated DNA replication initiation |
| C | 0030894 | cellular_component | replisome |
| C | 0032297 | biological_process | negative regulation of DNA-templated DNA replication initiation |
| C | 0042276 | biological_process | error-prone translesion synthesis |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0044787 | biological_process | bacterial-type DNA replication |
| C | 1990078 | cellular_component | replication inhibiting complex |
| C | 1990085 | cellular_component | Hda-beta clamp complex |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006260 | biological_process | DNA replication |
| D | 0006261 | biological_process | DNA-templated DNA replication |
| D | 0006271 | biological_process | DNA strand elongation involved in DNA replication |
| D | 0006974 | biological_process | DNA damage response |
| D | 0008408 | molecular_function | 3'-5' exonuclease activity |
| D | 0009360 | cellular_component | DNA polymerase III complex |
| D | 0030174 | biological_process | regulation of DNA-templated DNA replication initiation |
| D | 0030894 | cellular_component | replisome |
| D | 0032297 | biological_process | negative regulation of DNA-templated DNA replication initiation |
| D | 0042276 | biological_process | error-prone translesion synthesis |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0044787 | biological_process | bacterial-type DNA replication |
| D | 1990078 | cellular_component | replication inhibiting complex |
| D | 1990085 | cellular_component | Hda-beta clamp complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE A 401 |
| Chain | Residue |
| A | GLN15 |
| A | SER18 |
| A | GLY22 |
| A | ARG73 |
| A | PHE76 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue 1PE A 402 |
| Chain | Residue |
| A | ARG279 |
| B | ASP77 |
| A | ALA271 |
| A | ILE272 |
| A | SER274 |
| A | GLU276 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue 1PE A 403 |
| Chain | Residue |
| A | ALA58 |
| A | ASP229 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | ARG365 |
| C | ARG152 |
| J | PHE6 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | ASN295 |
| A | HOH546 |
| A | HOH577 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE B 401 |
| Chain | Residue |
| B | SER18 |
| B | ARG73 |
| B | PHE76 |
| B | HOH565 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE B 402 |
| Chain | Residue |
| B | GLU140 |
| B | ASN329 |
| B | ALA330 |
| B | LYS332 |
| B | 1PE406 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue 1PE B 403 |
| Chain | Residue |
| B | GLN149 |
| B | ASP150 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE B 404 |
| Chain | Residue |
| B | GLU161 |
| B | GLU163 |
| B | SER192 |
| B | ARG245 |
| B | HOH528 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue 1PE B 405 |
| Chain | Residue |
| B | PRO213 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE B 406 |
| Chain | Residue |
| B | ARG137 |
| B | 1PE402 |
| D | ASP211 |
| D | ASN212 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE B 407 |
| Chain | Residue |
| B | HIS9 |
| B | ARG56 |
| B | ALA58 |
| B | VAL60 |
| B | ASP229 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 408 |
| Chain | Residue |
| B | SER-1 |
| B | ALA67 |
| B | THR68 |
| B | LEU92 |
| B | GLY94 |
| B | GLU95 |
| B | ALA113 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 409 |
| Chain | Residue |
| B | ARG282 |
| B | ASN295 |
| B | LEU366 |
| B | HOH502 |
| B | HOH516 |
| B | HOH574 |
| site_id | AD6 |
| Number of Residues | 10 |
| Details | binding site for residue 1PE C 401 |
| Chain | Residue |
| A | ASP307 |
| A | VAL308 |
| A | THR309 |
| A | GLU334 |
| A | ASN335 |
| C | GLU257 |
| C | ALA258 |
| C | VAL308 |
| C | THR309 |
| C | ASN335 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue 1PE C 402 |
| Chain | Residue |
| C | PRO83 |
| C | SER101 |
| C | GLY102 |
| C | ARG103 |
| C | SER104 |
| D | ARG269 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE C 403 |
| Chain | Residue |
| C | SER18 |
| C | GLY22 |
| C | ARG73 |
| C | PHE76 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE D 401 |
| Chain | Residue |
| D | TYR154 |
| D | ARG240 |
| D | PRO242 |
| D | ASP243 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE D 402 |
| Chain | Residue |
| D | ARG7 |
| D | ARG80 |
| D | GLY81 |
| D | LEU82 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL D 403 |
| Chain | Residue |
| D | ASN295 |
| D | LEU366 |
| D | HOH509 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL H 101 |
| Chain | Residue |
| C | HIS175 |
| H | ASP4 |
| J | GLN2 |
| J | ASP4 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residue 1PE I 101 |
| Chain | Residue |
| I | ASP4 |
| B | ARG365 |
| D | TYR153 |
| D | TYR154 |
| D | GLY239 |
| D | ARG240 |
| I | GLN2 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL I 102 |
| Chain | Residue |
| B | ARG152 |
| D | ARG152 |
| I | PHE6 |
| K | PHE6 |
| site_id | AE6 |
| Number of Residues | 8 |
| Details | binding site for residue 1PE K 101 |
| Chain | Residue |
| B | TYR153 |
| B | TYR154 |
| B | GLY239 |
| B | ARG240 |
| D | VAL344 |
| K | GLN2 |
| K | ALC3 |
| K | ASP4 |
| site_id | AE7 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide ACE H 1 and GLN H 2 |
| Chain | Residue |
| A | HIS175 |
| A | TYR323 |
| A | MET362 |
| A | PRO363 |
| A | MET364 |
| A | ARG365 |
| C | VAL151 |
| H | ALC3 |
| H | HOH201 |
| site_id | AE8 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide GLN H 2 and ALC H 3 |
| Chain | Residue |
| A | HIS175 |
| A | TYR323 |
| A | MET362 |
| A | PRO363 |
| A | MET364 |
| A | ARG365 |
| H | ACE1 |
| H | ASP4 |
| H | HOH201 |
| site_id | AE9 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide ALC H 3 and ASP H 4 |
| Chain | Residue |
| A | GLY174 |
| A | HIS175 |
| A | MET362 |
| A | PRO363 |
| A | ARG365 |
| H | ACE1 |
| H | GLN2 |
| H | LEU5 |
| H | PHE6 |
| H | GOL101 |
| H | HOH202 |
| site_id | AF1 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide ACE I 1 and GLN I 2 |
| Chain | Residue |
| B | HIS175 |
| B | TYR323 |
| B | MET362 |
| B | PRO363 |
| B | MET364 |
| B | ARG365 |
| D | TYR153 |
| I | ALC3 |
| I | 1PE101 |
| I | HOH201 |
| I | HOH202 |
| I | HOH203 |
| site_id | AF2 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide GLN I 2 and ALC I 3 |
| Chain | Residue |
| B | HIS175 |
| B | TYR323 |
| B | MET362 |
| B | PRO363 |
| B | MET364 |
| B | ARG365 |
| D | TYR153 |
| D | ARG240 |
| I | ACE1 |
| I | ASP4 |
| I | 1PE101 |
| I | HOH201 |
| I | HOH202 |
| I | HOH203 |
| site_id | AF3 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide ALC I 3 and ASP I 4 |
| Chain | Residue |
| B | GLY174 |
| B | HIS175 |
| B | MET362 |
| B | PRO363 |
| B | ARG365 |
| B | HOH564 |
| D | ARG152 |
| D | TYR154 |
| D | ARG240 |
| I | ACE1 |
| I | GLN2 |
| I | LEU5 |
| I | PHE6 |
| I | 1PE101 |
| I | HOH201 |
| site_id | AF4 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide ACE J 1 and GLN J 2 |
| Chain | Residue |
| A | VAL151 |
| C | HIS175 |
| C | MET362 |
| C | PRO363 |
| C | MET364 |
| C | ARG365 |
| H | GOL101 |
| J | ALC3 |
| J | HOH101 |
| J | HOH102 |
| site_id | AF5 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide GLN J 2 and ALC J 3 |
| Chain | Residue |
| C | HIS175 |
| C | VAL344 |
| C | MET362 |
| C | PRO363 |
| C | MET364 |
| H | GOL101 |
| J | ACE1 |
| J | ASP4 |
| J | HOH101 |
| J | HOH102 |
| site_id | AF6 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide ALC J 3 and ASP J 4 |
| Chain | Residue |
| C | GLY174 |
| C | HIS175 |
| C | VAL344 |
| C | MET362 |
| C | PRO363 |
| H | GOL101 |
| J | ACE1 |
| J | GLN2 |
| J | LEU5 |
| J | PHE6 |
| site_id | AF7 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide ACE K 1 and GLN K 2 |
| Chain | Residue |
| B | TYR153 |
| D | HIS175 |
| D | MET362 |
| D | PRO363 |
| D | MET364 |
| D | ARG365 |
| D | HOH513 |
| K | ALC3 |
| K | 1PE101 |
| K | HOH201 |
| K | HOH202 |
| site_id | AF8 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide GLN K 2 and ALC K 3 |
| Chain | Residue |
| B | TYR153 |
| B | ARG240 |
| D | HIS175 |
| D | MET362 |
| D | PRO363 |
| D | MET364 |
| D | HOH513 |
| K | ACE1 |
| K | ASP4 |
| K | 1PE101 |
| K | HOH201 |
| K | HOH202 |
| site_id | AF9 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide ALC K 3 and ASP K 4 |
| Chain | Residue |
| B | TYR154 |
| B | ARG240 |
| D | HIS175 |
| D | MET362 |
| D | PRO363 |
| D | HOH513 |
| K | ACE1 |
| K | GLN2 |
| K | LEU5 |
| K | PHE6 |
| K | 1PE101 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:18191219 |
| Chain | Residue | Details |
| B | GLN149 | |
| B | TYR153 | |
| C | ARG24 | |
| C | GLN149 | |
| C | TYR153 | |
| D | ARG24 | |
| D | GLN149 | |
| D | TYR153 | |
| A | ARG24 | |
| A | GLN149 | |
| A | TYR153 | |
| B | ARG24 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18191219 |
| Chain | Residue | Details |
| A | ARG73 | |
| B | ARG73 | |
| C | ARG73 | |
| D | ARG73 |
