6FTG

Subtomogram average of OST-containing ribosome-translocon complexes from canine rough microsomal membranes

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
3	0006486	biological_process	protein glycosylation
3	0008250	cellular_component	oligosaccharyltransferase complex
5	0004576	molecular_function	oligosaccharyl transferase activity
5	0004579	molecular_function	dolichyl-diphosphooligosaccharide-protein glycotransferase activity
5	0005783	cellular_component	endoplasmic reticulum
5	0005789	cellular_component	endoplasmic reticulum membrane
5	0006486	biological_process	protein glycosylation
5	0016020	cellular_component	membrane
5	0016740	molecular_function	transferase activity
5	0016757	molecular_function	glycosyltransferase activity
5	0018279	biological_process	protein N-linked glycosylation via asparagine
5	0035000	cellular_component	oligosaccharyltransferase III complex
5	0043687	biological_process	post-translational protein modification
5	0046872	molecular_function	metal ion binding
A	0003735	molecular_function	structural constituent of ribosome
A	0005840	cellular_component	ribosome
A	0006412	biological_process	translation
B	0003723	molecular_function	RNA binding
B	0003735	molecular_function	structural constituent of ribosome
B	0005634	cellular_component	nucleus
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005840	cellular_component	ribosome
B	0006412	biological_process	translation
B	0022625	cellular_component	cytosolic large ribosomal subunit
B	1990904	cellular_component	ribonucleoprotein complex
C	0003735	molecular_function	structural constituent of ribosome
C	0005840	cellular_component	ribosome
C	0006412	biological_process	translation
D	0003735	molecular_function	structural constituent of ribosome
D	0005840	cellular_component	ribosome
D	0006412	biological_process	translation
D	0008097	molecular_function	5S rRNA binding
E	0003735	molecular_function	structural constituent of ribosome
E	0005840	cellular_component	ribosome
E	0006412	biological_process	translation
F	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F	0003735	molecular_function	structural constituent of ribosome
F	0022625	cellular_component	cytosolic large ribosomal subunit
G	0042254	biological_process	ribosome biogenesis
G	1990904	cellular_component	ribonucleoprotein complex
H	0002181	biological_process	cytoplasmic translation
H	0003735	molecular_function	structural constituent of ribosome
H	0005737	cellular_component	cytoplasm
H	0005840	cellular_component	ribosome
H	0006412	biological_process	translation
H	0019843	molecular_function	rRNA binding
H	0022625	cellular_component	cytosolic large ribosomal subunit
H	1990904	cellular_component	ribonucleoprotein complex
I	0003735	molecular_function	structural constituent of ribosome
I	0005737	cellular_component	cytoplasm
I	0005840	cellular_component	ribosome
I	0006412	biological_process	translation
I	0006417	biological_process	regulation of translation
I	0022625	cellular_component	cytosolic large ribosomal subunit
I	1990904	cellular_component	ribonucleoprotein complex
J	0003723	molecular_function	RNA binding
J	0003735	molecular_function	structural constituent of ribosome
J	0005634	cellular_component	nucleus
J	0005730	cellular_component	nucleolus
J	0005737	cellular_component	cytoplasm
J	0005840	cellular_component	ribosome
J	0006412	biological_process	translation
J	0019843	molecular_function	rRNA binding
J	0022625	cellular_component	cytosolic large ribosomal subunit
J	1990904	cellular_component	ribonucleoprotein complex
L	0003735	molecular_function	structural constituent of ribosome
L	0005840	cellular_component	ribosome
L	0006412	biological_process	translation
M	0003723	molecular_function	RNA binding
M	0003735	molecular_function	structural constituent of ribosome
M	0005840	cellular_component	ribosome
M	0006412	biological_process	translation
N	0002181	biological_process	cytoplasmic translation
N	0003723	molecular_function	RNA binding
N	0003735	molecular_function	structural constituent of ribosome
N	0005737	cellular_component	cytoplasm
N	0005840	cellular_component	ribosome
N	0006412	biological_process	translation
N	0022625	cellular_component	cytosolic large ribosomal subunit
N	0022626	cellular_component	cytosolic ribosome
N	0044391	cellular_component	ribosomal subunit
N	1990904	cellular_component	ribonucleoprotein complex
O	0003735	molecular_function	structural constituent of ribosome
O	0005840	cellular_component	ribosome
O	0006412	biological_process	translation
O	0015934	cellular_component	large ribosomal subunit
P	0003735	molecular_function	structural constituent of ribosome
P	0005840	cellular_component	ribosome
P	0006412	biological_process	translation
P	0015934	cellular_component	large ribosomal subunit
Q	0003735	molecular_function	structural constituent of ribosome
Q	0005840	cellular_component	ribosome
Q	0006412	biological_process	translation
R	0003723	molecular_function	RNA binding
R	0003735	molecular_function	structural constituent of ribosome
R	0005840	cellular_component	ribosome
R	0006412	biological_process	translation
R	0022625	cellular_component	cytosolic large ribosomal subunit
S	0003735	molecular_function	structural constituent of ribosome
S	0005840	cellular_component	ribosome
S	0006412	biological_process	translation
T	0003735	molecular_function	structural constituent of ribosome
T	0005737	cellular_component	cytoplasm
T	0005783	cellular_component	endoplasmic reticulum
T	0005829	cellular_component	cytosol
T	0005840	cellular_component	ribosome
T	0006412	biological_process	translation
T	0022625	cellular_component	cytosolic large ribosomal subunit
T	1990904	cellular_component	ribonucleoprotein complex
U	0003735	molecular_function	structural constituent of ribosome
U	0005840	cellular_component	ribosome
U	0006412	biological_process	translation
V	0000122	biological_process	negative regulation of transcription by RNA polymerase II
V	0001223	molecular_function	transcription coactivator binding
V	0003735	molecular_function	structural constituent of ribosome
V	0005654	cellular_component	nucleoplasm
V	0005730	cellular_component	nucleolus
V	0005737	cellular_component	cytoplasm
V	0005840	cellular_component	ribosome
V	0006412	biological_process	translation
V	0008284	biological_process	positive regulation of cell population proliferation
V	0010628	biological_process	positive regulation of gene expression
V	0022625	cellular_component	cytosolic large ribosomal subunit
V	0022626	cellular_component	cytosolic ribosome
V	0031625	molecular_function	ubiquitin protein ligase binding
V	0032986	biological_process	protein-DNA complex disassembly
V	0032991	cellular_component	protein-containing complex
V	0045202	cellular_component	synapse
V	0050821	biological_process	protein stabilization
V	0070180	molecular_function	large ribosomal subunit rRNA binding
V	0070314	biological_process	G1 to G0 transition
V	0072717	biological_process	cellular response to actinomycin D
V	1901798	biological_process	positive regulation of signal transduction by p53 class mediator
V	1903450	biological_process	regulation of G1 to G0 transition
V	1990904	cellular_component	ribonucleoprotein complex
V	1990948	molecular_function	ubiquitin ligase inhibitor activity
V	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
X	0003735	molecular_function	structural constituent of ribosome
X	0005840	cellular_component	ribosome
X	0006412	biological_process	translation
X	0019843	molecular_function	rRNA binding
Y	0002181	biological_process	cytoplasmic translation
Y	0003723	molecular_function	RNA binding
Y	0003735	molecular_function	structural constituent of ribosome
Y	0005654	cellular_component	nucleoplasm
Y	0005730	cellular_component	nucleolus
Y	0005737	cellular_component	cytoplasm
Y	0005840	cellular_component	ribosome
Y	0006364	biological_process	rRNA processing
Y	0006412	biological_process	translation
Y	0006977	biological_process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Y	0015934	cellular_component	large ribosomal subunit
Y	0022625	cellular_component	cytosolic large ribosomal subunit
Y	0022626	cellular_component	cytosolic ribosome
Y	0034644	biological_process	cellular response to UV
Y	0042273	biological_process	ribosomal large subunit biogenesis
Y	0045202	cellular_component	synapse
Y	0045727	biological_process	positive regulation of translation
Y	0048027	molecular_function	mRNA 5'-UTR binding
Y	0071479	biological_process	cellular response to ionizing radiation
Y	0071480	biological_process	cellular response to gamma radiation
Y	1902164	biological_process	positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
Y	1902167	biological_process	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Y	1904803	biological_process	regulation of translation involved in cellular response to UV
Y	1990904	cellular_component	ribonucleoprotein complex
Z	0003735	molecular_function	structural constituent of ribosome
Z	0005654	cellular_component	nucleoplasm
Z	0005730	cellular_component	nucleolus
Z	0005737	cellular_component	cytoplasm
Z	0005783	cellular_component	endoplasmic reticulum
Z	0005791	cellular_component	rough endoplasmic reticulum
Z	0005829	cellular_component	cytosol
Z	0005840	cellular_component	ribosome
Z	0006364	biological_process	rRNA processing
Z	0006412	biological_process	translation
Z	0022625	cellular_component	cytosolic large ribosomal subunit
Z	0022626	cellular_component	cytosolic ribosome
Z	1990904	cellular_component	ribonucleoprotein complex
a	0003735	molecular_function	structural constituent of ribosome
a	0005737	cellular_component	cytoplasm
a	0005840	cellular_component	ribosome
a	0006412	biological_process	translation
a	0015934	cellular_component	large ribosomal subunit
a	0022625	cellular_component	cytosolic large ribosomal subunit
a	0043232	cellular_component	intracellular non-membrane-bounded organelle
a	1990904	cellular_component	ribonucleoprotein complex
b	0003735	molecular_function	structural constituent of ribosome
b	0005840	cellular_component	ribosome
b	0006412	biological_process	translation
c	0003723	molecular_function	RNA binding
d	0003735	molecular_function	structural constituent of ribosome
d	0005840	cellular_component	ribosome
d	0006412	biological_process	translation
e	0003735	molecular_function	structural constituent of ribosome
e	0005737	cellular_component	cytoplasm
e	0005840	cellular_component	ribosome
e	0006412	biological_process	translation
e	0022625	cellular_component	cytosolic large ribosomal subunit
e	1990904	cellular_component	ribonucleoprotein complex
f	0000049	molecular_function	tRNA binding
f	0002181	biological_process	cytoplasmic translation
f	0003723	molecular_function	RNA binding
f	0003735	molecular_function	structural constituent of ribosome
f	0005737	cellular_component	cytoplasm
f	0005840	cellular_component	ribosome
f	0006412	biological_process	translation
f	0022625	cellular_component	cytosolic large ribosomal subunit
f	0042273	biological_process	ribosomal large subunit biogenesis
f	1990904	cellular_component	ribonucleoprotein complex
g	0003735	molecular_function	structural constituent of ribosome
g	0005840	cellular_component	ribosome
g	0006412	biological_process	translation
h	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
h	0003729	molecular_function	mRNA binding
h	0003735	molecular_function	structural constituent of ribosome
h	0005737	cellular_component	cytoplasm
h	0005840	cellular_component	ribosome
h	0006412	biological_process	translation
h	0022625	cellular_component	cytosolic large ribosomal subunit
h	1990904	cellular_component	ribonucleoprotein complex
i	0003735	molecular_function	structural constituent of ribosome
i	0005840	cellular_component	ribosome
i	0006412	biological_process	translation
j	0003735	molecular_function	structural constituent of ribosome
j	0005840	cellular_component	ribosome
j	0006412	biological_process	translation
k	0003735	molecular_function	structural constituent of ribosome
k	0005840	cellular_component	ribosome
k	0006412	biological_process	translation
l	0003735	molecular_function	structural constituent of ribosome
l	0005737	cellular_component	cytoplasm
l	0005840	cellular_component	ribosome
l	0006412	biological_process	translation
l	0022625	cellular_component	cytosolic large ribosomal subunit
l	1990904	cellular_component	ribonucleoprotein complex
m	0003735	molecular_function	structural constituent of ribosome
m	0005840	cellular_component	ribosome
m	0006412	biological_process	translation
n	0003735	molecular_function	structural constituent of ribosome
n	0005737	cellular_component	cytoplasm
n	0005840	cellular_component	ribosome
n	0006412	biological_process	translation
n	1990904	cellular_component	ribonucleoprotein complex
o	0003735	molecular_function	structural constituent of ribosome
o	0005840	cellular_component	ribosome
o	0006412	biological_process	translation
p	0003735	molecular_function	structural constituent of ribosome
p	0005737	cellular_component	cytoplasm
p	0005840	cellular_component	ribosome
p	0006412	biological_process	translation
p	0022625	cellular_component	cytosolic large ribosomal subunit
p	0046872	molecular_function	metal ion binding
p	1990904	cellular_component	ribonucleoprotein complex
r	0003735	molecular_function	structural constituent of ribosome
r	0005737	cellular_component	cytoplasm
r	0005840	cellular_component	ribosome
r	0006412	biological_process	translation
r	0022625	cellular_component	cytosolic large ribosomal subunit
r	1990904	cellular_component	ribonucleoprotein complex
t	0003723	molecular_function	RNA binding
t	0003735	molecular_function	structural constituent of ribosome
t	0005737	cellular_component	cytoplasm
t	0005840	cellular_component	ribosome
t	0006412	biological_process	translation
t	0022625	cellular_component	cytosolic large ribosomal subunit
t	0070180	molecular_function	large ribosomal subunit rRNA binding
t	1990904	cellular_component	ribonucleoprotein complex
x	0005048	molecular_function	signal sequence binding
x	0005783	cellular_component	endoplasmic reticulum
x	0005784	cellular_component	Sec61 translocon complex
x	0005789	cellular_component	endoplasmic reticulum membrane
x	0006613	biological_process	cotranslational protein targeting to membrane
x	0006616	biological_process	SRP-dependent cotranslational protein targeting to membrane, translocation
x	0008320	molecular_function	protein transmembrane transporter activity
x	0015031	biological_process	protein transport
x	0016020	cellular_component	membrane
x	0031204	biological_process	post-translational protein targeting to membrane, translocation
x	0039019	biological_process	pronephric nephron development
x	0043022	molecular_function	ribosome binding
x	0045047	biological_process	protein targeting to ER
x	0045048	biological_process	protein insertion into ER membrane
y	0005543	molecular_function	phospholipid binding
y	0005783	cellular_component	endoplasmic reticulum
y	0005789	cellular_component	endoplasmic reticulum membrane
y	0006605	biological_process	protein targeting
y	0006886	biological_process	intracellular protein transport
y	0008320	molecular_function	protein transmembrane transporter activity
y	0015031	biological_process	protein transport
y	0016020	cellular_component	membrane
y	0022406	biological_process	membrane docking
y	0031204	biological_process	post-translational protein targeting to membrane, translocation
y	0043022	molecular_function	ribosome binding
y	0045047	biological_process	protein targeting to ER
y	0071261	cellular_component	Ssh1 translocon complex

Functional Information from PROSITE/UniProt

site_id	PS00049
Number of Residues	27
Details	RIBOSOMAL_L14 Ribosomal protein L14 signature. AVVIrqrksyrrk.DGvflyFedNagVI

Chain	Residue	Details
V	ALA79-ILE105

---

site_id	PS01257
Number of Residues	22
Details	RIBOSOMAL_L10E Ribosomal protein L10e signature. ADRlqtGMRgAFGKPqGtvARV

Chain	Residue	Details
I	ALA108-VAL129

---

site_id	PS00050
Number of Residues	16
Details	RIBOSOMAL_L23 Ribosomal protein L23 signature. KKAYVRLApdydaldV

Chain	Residue	Details
X	LYS134-VAL149

---

site_id	PS01073
Number of Residues	18
Details	RIBOSOMAL_L24E Ribosomal protein L24e signature. FsGykIyPGhGrrYaRtD

Chain	Residue	Details
W	PHE8-ASP25

---

site_id	PS01145
Number of Residues	14
Details	RIBOSOMAL_L34E Ribosomal protein L34e signature. TaSnKtrlsRTPGN

Chain	Residue	Details
g	THR15-ASN28

---

site_id	PS01171
Number of Residues	26
Details	RIBOSOMAL_L21E Ribosomal protein L21e signature. GDiVdikgmgtvqk.GmpHkcYhGkTG

Chain	Residue	Details
T	GLY37-GLY62

---

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CrkmgVPYciLkGKarLG

Chain	Residue	Details
G	CYS174-GLY191

---

site_id	PS01077
Number of Residues	20
Details	RIBOSOMAL_L37E Ribosomal protein L37e signature. GTsSfGkRrnkt.HtlCrRCG

Chain	Residue	Details
j	GLY4-GLY23

---

site_id	PS00580
Number of Residues	21
Details	RIBOSOMAL_L32E Ribosomal protein L32e signature. FiRhqsdRyvKIkrn..WRKprG

Chain	Residue	Details
e	PHE20-GLY40

---

site_id	PS00700
Number of Residues	22
Details	RIBOSOMAL_L6_2 Ribosomal protein L6 signature 2. QattVknKdiRkFlDGIYVseK

Chain	Residue	Details
H	GLN163-LYS184

---

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GESSGKNV

Chain	Residue	Details
C	GLY15-VAL22

---

site_id	PS00939
Number of Residues	27
Details	RIBOSOMAL_L1E Ribosomal protein L1e signature. NttqKryAIcSALaASAlpalvmsKGH

Chain	Residue	Details
C	ASN116-HIS142

---

site_id	PS01144
Number of Residues	15
Details	RIBOSOMAL_L31E Ribosomal protein L31e signature. VRIDtrLNkAvWaKG

Chain	Residue	Details
d	VAL62-GLY76

---

site_id	PS01104
Number of Residues	15
Details	RIBOSOMAL_L13E Ribosomal protein L13e signature. RaGRGFSLeELrvaG

Chain	Residue	Details
L	ARG71-GLY85

---

site_id	PS01067
Number of Residues	29
Details	SECE_SEC61G Protein secE/sec61-gamma signature. FvKDsIrlVkRctKPdrkEfqkiaMATAI

Chain	Residue	Details
y	PHE14-ILE42

---

site_id	PS00359
Number of Residues	16
Details	RIBOSOMAL_L11 Ribosomal protein L11 signature. KeIlGTaqSVGcNVdG

Chain	Residue	Details
t	LYS130-GLY145

---

site_id	PS01106
Number of Residues	18
Details	RIBOSOMAL_L18E Ribosomal protein L18e signature. KrLfmSRtnRPpLSLsRM

Chain	Residue	Details
Q	LYS49-MET66

---

site_id	PS00467
Number of Residues	12
Details	RIBOSOMAL_L2 Ribosomal protein L2 signature. PrvRGVAmNPvE

Chain	Residue	Details
A	PRO197-GLU208

---

site_id	PS00358
Number of Residues	17
Details	RIBOSOMAL_L5 Ribosomal protein L5 signature. LeqLTGQtpVfSkARyT

Chain	Residue	Details
J	LEU40-THR56

---

site_id	PS01170
Number of Residues	19
Details	RIBOSOMAL_L6E Ribosomal protein L6e signature. NrvPLRRthqkFVIATSt.K

Chain	Residue	Details
E	ASN178-LYS196

---

site_id	PS00756
Number of Residues	19
Details	SECY_2 Protein secY signature 2. LLdElLQkgyGLGSGiSLF

Chain	Residue	Details
x	LEU164-PHE182

---

site_id	PS00755
Number of Residues	20
Details	SECY_1 Protein secY signature 1. TLMeLGIsPIVtSGLIMQLL

Chain	Residue	Details
x	THR75-LEU94

---

site_id	PS01190
Number of Residues	11
Details	RIBOSOMAL_L36E Ribosomal protein L36e signature. PYERRaMELLK

Chain	Residue	Details
i	PRO52-LYS62

---

site_id	PS00475
Number of Residues	32
Details	RIBOSOMAL_L15 Ribosomal protein L15 signature. KVLGkGkLpkqp.ViVkakfFSrrAeekIkgvG

Chain	Residue	Details
a	LYS110-GLY141

---

site_id	PS00783
Number of Residues	24
Details	RIBOSOMAL_L13 Ribosomal protein L13 signature. VRGMLPhktkrGQaaldrLkVFdG

Chain	Residue	Details
O	VAL84-GLY107

---

site_id	PS01172
Number of Residues	12
Details	RIBOSOMAL_L44E Ribosomal protein L44e signature. KtTKKivLRleC

Chain	Residue	Details
o	LYS61-CYS72

---

site_id	PS00464
Number of Residues	25
Details	RIBOSOMAL_L22 Ribosomal protein L22 signature. RrrTyRAhGRinpymsspCHIEMiL

Chain	Residue	Details
P	ARG126-LEU150

---

site_id	PS00579
Number of Residues	15
Details	RIBOSOMAL_L29 Ribosomal protein L29 signature. KLSKIRvVRKSIARV

Chain	Residue	Details
h	LYS43-VAL57

---

site_id	PS01107
Number of Residues	12
Details	RIBOSOMAL_L27E Ribosomal protein L27e signature. GKNkWFFqkLRF

Chain	Residue	Details
Z	GLY125-PHE136

---

site_id	PS00474
Number of Residues	24
Details	RIBOSOMAL_L3 Ribosomal protein L3 signature. FgqdemiDviGvTkGKGykGvtsR

Chain	Residue	Details
B	PHE211-ARG234

---

site_id	PS01105
Number of Residues	22
Details	RIBOSOMAL_L35AE Ribosomal protein L35Ae signature. GKVtRaHGnsGmVrAkFrsnLP

Chain	Residue	Details
f	GLY72-PRO93

---

site_id	PS00051
Number of Residues	17
Details	RIBOSOMAL_L39E Ribosomal protein L39e signature. KTgnkIryNskrRHWRR

Chain	Residue	Details
l	LYS30-ARG46

---

site_id	PS01194
Number of Residues	24
Details	RIBOSOMAL_L15E Ribosomal protein L15e signature. DKARrLGYkAkqGYVIYRiRVrRG

Chain	Residue	Details
N	ASP46-GLY69

---

site_id	PS00709
Number of Residues	25
Details	RIBOSOMAL_L30E_1 Ribosomal protein L30e signature 1. SgkyvlGyKqtLKmiRqGkaKlVIL

Chain	Residue	Details
c	SER24-LEU48

---

site_id	PS00993
Number of Residues	21
Details	RIBOSOMAL_L30E_2 Ribosomal protein L30e signature 2. ELGTacGKyyrvctLaIiDpG

Chain	Residue	Details
c	GLU80-GLY100

---

site_id	PS01108
Number of Residues	19
Details	RIBOSOMAL_L24 Ribosomal protein L24 signature. DDeVqVVrGhyKGqqiGkV

Chain	Residue	Details
Y	ASP52-VAL70

---

site_id	PS00526
Number of Residues	20
Details	RIBOSOMAL_L19E Ribosomal protein L19e signature. QKRLaSsvlrCGkkkVWLDP

Chain	Residue	Details
R	GLN7-PRO26

---

site_id	PS00634
Number of Residues	33
Details	RIBOSOMAL_L30 Ribosomal protein L30 signature. VLqlLrLrQifNgTfvklnkasinMLriVepYI

Chain	Residue	Details
F	VAL110-ILE142

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	63
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
5	MET1-LEU17
x	GLY444-PHE458
5	LYS139-ASP140
5	GLY190-SER191
5	THR229-SER233
5	SER288-ARG300
5	SER380-ALA385
5	TYR429-LYS453
x	ASP357-TRP379
x	ALA421-PHE437

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
5	LEU18-VAL38
5	SER301-GLY321
x	SER197-ASN241
x	MET307-GLU356
x	LEU438-SER443

---

site_id	SWS_FT_FI3
Number of Residues	369
Details	TOPO_DOM: Lumenal => ECO:0000305

Chain	Residue	Details
5	LEU39-LEU119
5	SER159-GLU169
5	SER207-GLY211
5	GLN260-HIS267
5	LYS322-THR356
5	MET403-LEU406
5	HIS474-THR705

---

site_id	SWS_FT_FI4
Number of Residues	206
Details	TRANSMEM: Helical => ECO:0000250|UniProtKB:P39007

Chain	Residue	Details
5	ALA120-LEU138
5	MET407-THR428
5	ASN454-PHE473
5	ALA141-ILE158
5	GLY170-THR189
5	ILE192-VAL206
5	TYR212-LEU228
5	HIS234-PHE259
5	MET268-ARG287
5	TRP357-PHE379
5	ARG386-VAL402

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	BINDING: BINDING => ECO:0000250|UniProtKB:B9KDD4

Chain	Residue	Details
5	ASP49
5	ASP167
5	GLU169
5	ARG405
5	TYR530

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	SITE: Interacts with target acceptor peptide in protein substrate => ECO:0000250|UniProtKB:B9KDD4

Chain	Residue	Details
5	ASP49
5	GLU351
5	LYS595
B	LYS226
B	LYS386
B	LYS393

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	SITE: Important for catalytic activity => ECO:0000250|UniProtKB:B9KDD4

Chain	Residue	Details
5	ARG160
B	LYS366

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498

Chain	Residue	Details
5	ASN537
5	ASN544

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000250|UniProtKB:P39007

Chain	Residue	Details
5	ASN548
C	VAL313

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate => ECO:0000250|UniProtKB:P36578

Chain	Residue	Details
C	HIS347

---