6FQZ
Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004616 | molecular_function | phosphogluconate dehydrogenase (decarboxylating) activity |
A | 0005829 | cellular_component | cytosol |
A | 0006098 | biological_process | pentose-phosphate shunt |
A | 0009051 | biological_process | pentose-phosphate shunt, oxidative branch |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0019521 | biological_process | D-gluconate metabolic process |
A | 0046177 | biological_process | D-gluconate catabolic process |
A | 0050661 | molecular_function | NADP binding |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004616 | molecular_function | phosphogluconate dehydrogenase (decarboxylating) activity |
B | 0005829 | cellular_component | cytosol |
B | 0006098 | biological_process | pentose-phosphate shunt |
B | 0009051 | biological_process | pentose-phosphate shunt, oxidative branch |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0019521 | biological_process | D-gluconate metabolic process |
B | 0046177 | biological_process | D-gluconate catabolic process |
B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 21 |
Details | binding site for residue 6PG A 501 |
Chain | Residue |
A | ASN102 |
A | ALA259 |
A | LYS260 |
A | ARG287 |
A | ILE367 |
A | HOH609 |
A | HOH615 |
A | HOH617 |
A | HOH679 |
A | HOH685 |
B | ARG447 |
A | SER128 |
B | PHE450 |
B | HIS453 |
A | GLY129 |
A | GLY130 |
A | LYS182 |
A | HIS185 |
A | ASN186 |
A | GLU189 |
A | TYR190 |
site_id | AC2 |
Number of Residues | 9 |
Details | binding site for residue GOL A 502 |
Chain | Residue |
A | MET267 |
A | THR271 |
A | ILE275 |
A | PRO276 |
A | CYS277 |
B | MET267 |
B | LEU284 |
B | ASP285 |
B | ASN288 |
site_id | AC3 |
Number of Residues | 7 |
Details | binding site for residue GOL A 503 |
Chain | Residue |
A | ILE188 |
A | CYS277 |
A | THR279 |
A | MET280 |
A | SER334 |
A | GLN337 |
A | GLY338 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue GOL A 504 |
Chain | Residue |
A | GLN444 |
A | ARG447 |
A | HIS453 |
A | THR454 |
A | HOH619 |
A | HOH655 |
B | LYS260 |
site_id | AC5 |
Number of Residues | 7 |
Details | binding site for residue GOL A 505 |
Chain | Residue |
A | TYR455 |
A | ARG457 |
A | TYR464 |
A | THR466 |
A | GOL510 |
B | ASP243 |
B | LEU244 |
site_id | AC6 |
Number of Residues | 9 |
Details | binding site for residue GOL A 506 |
Chain | Residue |
A | CYS281 |
A | ASP285 |
A | ASN288 |
B | ALA270 |
B | THR271 |
B | ILE275 |
B | PRO276 |
B | CYS277 |
B | CYS281 |
site_id | AC7 |
Number of Residues | 9 |
Details | binding site for residue GOL A 507 |
Chain | Residue |
A | THR414 |
A | ILE418 |
A | PRO419 |
A | ILE420 |
A | SER424 |
B | VAL410 |
B | ALA428 |
B | GLN431 |
B | HOH604 |
site_id | AC8 |
Number of Residues | 3 |
Details | binding site for residue GOL A 508 |
Chain | Residue |
A | TRP104 |
A | TRP265 |
B | GLU272 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue GOL A 509 |
Chain | Residue |
A | TRP468 |
A | HOH671 |
B | ARG460 |
B | GLU461 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue GOL A 510 |
Chain | Residue |
A | THR466 |
A | LEU467 |
A | GOL505 |
B | LYS240 |
B | ASP243 |
site_id | AD2 |
Number of Residues | 3 |
Details | binding site for residue GOL A 511 |
Chain | Residue |
A | ASN31 |
A | ARG32 |
A | ASN83 |
site_id | AD3 |
Number of Residues | 2 |
Details | binding site for residue PEG A 512 |
Chain | Residue |
A | GLY261 |
A | LYS264 |
site_id | AD4 |
Number of Residues | 8 |
Details | binding site for residue PEG A 513 |
Chain | Residue |
A | CYS281 |
A | ALA282 |
A | ASP285 |
A | PRO421 |
A | SER424 |
B | CYS281 |
B | ASP285 |
B | ALA425 |
site_id | AD5 |
Number of Residues | 21 |
Details | binding site for residue 6PG B 501 |
Chain | Residue |
B | SER128 |
B | GLY129 |
B | GLY130 |
B | LYS182 |
B | HIS185 |
B | ASN186 |
B | GLU189 |
B | TYR190 |
B | ALA259 |
B | LYS260 |
B | ARG287 |
B | ILE367 |
B | HOH627 |
B | HOH650 |
B | HOH678 |
B | HOH695 |
A | ARG447 |
A | PHE450 |
A | HIS453 |
A | HOH689 |
B | ASN102 |
site_id | AD6 |
Number of Residues | 7 |
Details | binding site for residue GOL B 502 |
Chain | Residue |
A | ALA428 |
A | GLN431 |
B | ALA413 |
B | THR414 |
B | ILE418 |
B | ILE420 |
B | SER424 |
site_id | AD7 |
Number of Residues | 5 |
Details | binding site for residue GOL B 503 |
Chain | Residue |
B | CYS277 |
B | MET280 |
B | SER334 |
B | GLN337 |
B | GLY338 |
site_id | AD8 |
Number of Residues | 9 |
Details | binding site for residue GOL B 504 |
Chain | Residue |
A | ASN437 |
A | LEU438 |
B | TYR200 |
B | VAL201 |
B | LYS204 |
B | HIS205 |
B | HOH609 |
B | HOH636 |
B | HOH704 |
site_id | AD9 |
Number of Residues | 7 |
Details | binding site for residue GOL B 505 |
Chain | Residue |
A | ASP243 |
A | LEU244 |
B | TYR455 |
B | ARG457 |
B | THR466 |
B | HOH640 |
B | HOH693 |
site_id | AE1 |
Number of Residues | 6 |
Details | binding site for residue GOL B 506 |
Chain | Residue |
A | HOH667 |
B | GLN444 |
B | ARG447 |
B | HIS453 |
B | THR454 |
B | HOH653 |
site_id | AE2 |
Number of Residues | 4 |
Details | binding site for residue GOL B 507 |
Chain | Residue |
A | TYR449 |
B | GLU232 |
B | ARG369 |
B | GLU461 |
site_id | AE3 |
Number of Residues | 5 |
Details | binding site for residue GOL B 508 |
Chain | Residue |
A | GLU300 |
B | SER435 |
B | GLN436 |
B | ASN437 |
B | HOH617 |
site_id | AE4 |
Number of Residues | 6 |
Details | binding site for residue GOL B 509 |
Chain | Residue |
B | TYR171 |
B | ILE172 |
B | GLY173 |
B | TRP351 |
B | LYS352 |
B | HOH652 |
site_id | AE5 |
Number of Residues | 6 |
Details | binding site for residue GOL B 510 |
Chain | Residue |
A | ASP243 |
A | LEU244 |
B | SER22 |
B | GLU47 |
B | LEU49 |
B | ARG135 |
site_id | AE6 |
Number of Residues | 3 |
Details | binding site for residue PGE B 511 |
Chain | Residue |
B | ALA259 |
B | LYS264 |
B | TRP265 |
site_id | AE7 |
Number of Residues | 4 |
Details | binding site for residue PEG B 512 |
Chain | Residue |
B | GLY462 |
B | ASN463 |
B | TYR464 |
B | HIS465 |
site_id | AE8 |
Number of Residues | 2 |
Details | binding site for residue PEG B 513 |
Chain | Residue |
A | THR33 |
B | HOH605 |