6FQX
Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004616 | molecular_function | phosphogluconate dehydrogenase (decarboxylating) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006098 | biological_process | pentose-phosphate shunt |
| A | 0009051 | biological_process | pentose-phosphate shunt, oxidative branch |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019521 | biological_process | D-gluconate metabolic process |
| A | 0050661 | molecular_function | NADP binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004616 | molecular_function | phosphogluconate dehydrogenase (decarboxylating) activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006098 | biological_process | pentose-phosphate shunt |
| B | 0009051 | biological_process | pentose-phosphate shunt, oxidative branch |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019521 | biological_process | D-gluconate metabolic process |
| B | 0050661 | molecular_function | NADP binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004616 | molecular_function | phosphogluconate dehydrogenase (decarboxylating) activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006098 | biological_process | pentose-phosphate shunt |
| C | 0009051 | biological_process | pentose-phosphate shunt, oxidative branch |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0019521 | biological_process | D-gluconate metabolic process |
| C | 0050661 | molecular_function | NADP binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004616 | molecular_function | phosphogluconate dehydrogenase (decarboxylating) activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006098 | biological_process | pentose-phosphate shunt |
| D | 0009051 | biological_process | pentose-phosphate shunt, oxidative branch |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0019521 | biological_process | D-gluconate metabolic process |
| D | 0050661 | molecular_function | NADP binding |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0004616 | molecular_function | phosphogluconate dehydrogenase (decarboxylating) activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0006098 | biological_process | pentose-phosphate shunt |
| E | 0009051 | biological_process | pentose-phosphate shunt, oxidative branch |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0019521 | biological_process | D-gluconate metabolic process |
| E | 0050661 | molecular_function | NADP binding |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0004616 | molecular_function | phosphogluconate dehydrogenase (decarboxylating) activity |
| F | 0005829 | cellular_component | cytosol |
| F | 0006098 | biological_process | pentose-phosphate shunt |
| F | 0009051 | biological_process | pentose-phosphate shunt, oxidative branch |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0019521 | biological_process | D-gluconate metabolic process |
| F | 0050661 | molecular_function | NADP binding |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0004616 | molecular_function | phosphogluconate dehydrogenase (decarboxylating) activity |
| G | 0005829 | cellular_component | cytosol |
| G | 0006098 | biological_process | pentose-phosphate shunt |
| G | 0009051 | biological_process | pentose-phosphate shunt, oxidative branch |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0019521 | biological_process | D-gluconate metabolic process |
| G | 0050661 | molecular_function | NADP binding |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0004616 | molecular_function | phosphogluconate dehydrogenase (decarboxylating) activity |
| H | 0005829 | cellular_component | cytosol |
| H | 0006098 | biological_process | pentose-phosphate shunt |
| H | 0009051 | biological_process | pentose-phosphate shunt, oxidative branch |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0019521 | biological_process | D-gluconate metabolic process |
| H | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | ASN31 |
| A | ARG32 |
| A | LYS75 |
| A | ASN83 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| B | LYS204 |
| B | HIS205 |
| A | ASN437 |
| A | PRO439 |
| A | ASN441 |
| B | TYR200 |
| B | VAL201 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue PEG A 503 |
| Chain | Residue |
| A | ASN463 |
| A | HIS465 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue PEG A 504 |
| Chain | Residue |
| A | LEU467 |
| A | TRP468 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue PGE A 505 |
| Chain | Residue |
| A | ASN102 |
| A | LYS182 |
| A | GLU189 |
| A | TYR190 |
| B | ARG447 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 501 |
| Chain | Residue |
| A | ASP285 |
| A | ASN288 |
| B | MET267 |
| B | THR271 |
| B | ILE275 |
| B | PRO276 |
| B | CYS277 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| B | ASN62 |
| B | ARG68 |
| B | HIS90 |
| C | ASN350 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue GOL B 503 |
| Chain | Residue |
| B | TRP104 |
| B | TRP265 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 504 |
| Chain | Residue |
| A | HIS205 |
| B | ASN437 |
| B | LEU438 |
| B | PRO439 |
| B | ASN441 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue PEG B 505 |
| Chain | Residue |
| A | LEU403 |
| A | ARG407 |
| A | GLN431 |
| B | LYS305 |
| B | SER417 |
| B | HOH603 |
| B | HOH609 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue PGE B 506 |
| Chain | Residue |
| A | ARG447 |
| B | ASN186 |
| B | GLU189 |
| B | ILE367 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue GOL C 501 |
| Chain | Residue |
| C | MET267 |
| C | LEU284 |
| C | ASP285 |
| C | ASN288 |
| D | MET267 |
| D | THR271 |
| D | ILE275 |
| D | PRO276 |
| D | CYS277 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue PEG C 502 |
| Chain | Residue |
| C | LYS182 |
| C | ASN186 |
| C | GLU189 |
| C | TYR190 |
| C | LYS260 |
| D | ARG447 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL D 501 |
| Chain | Residue |
| C | MET267 |
| C | THR271 |
| C | ILE275 |
| C | PRO276 |
| C | CYS277 |
| D | LEU284 |
| D | ASP285 |
| D | ASN288 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue AE3 D 502 |
| Chain | Residue |
| C | ARG447 |
| D | SER128 |
| D | LYS182 |
| D | ASN186 |
| D | GLU189 |
| D | ILE367 |
| D | HOH610 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue GOL E 501 |
| Chain | Residue |
| E | TRP104 |
| E | TRP265 |
| F | GLU272 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue GOL E 502 |
| Chain | Residue |
| E | GLU272 |
| F | TRP104 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue PEG E 503 |
| Chain | Residue |
| E | ALA259 |
| E | GLY261 |
| E | LYS264 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue PEG E 504 |
| Chain | Residue |
| E | LYS182 |
| E | GLU189 |
| E | TYR190 |
| E | LYS260 |
| F | ARG447 |
| site_id | AE2 |
| Number of Residues | 10 |
| Details | binding site for residue GOL F 501 |
| Chain | Residue |
| F | LEU284 |
| F | ASP285 |
| F | ASN288 |
| E | MET267 |
| E | ALA270 |
| E | THR271 |
| E | ILE275 |
| E | PRO276 |
| E | CYS277 |
| F | MET267 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL F 502 |
| Chain | Residue |
| E | ASP285 |
| E | ASN288 |
| F | MET267 |
| F | PRO276 |
| F | CYS277 |
| F | CYS281 |
| site_id | AE4 |
| Number of Residues | 2 |
| Details | binding site for residue GOL F 503 |
| Chain | Residue |
| F | ASN31 |
| F | LEU73 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue PEG F 504 |
| Chain | Residue |
| E | ARG447 |
| F | TYR190 |
| F | ARG287 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue GOL H 501 |
| Chain | Residue |
| G | GLU272 |
| H | TRP265 |
| H | LEU268 |
| site_id | AE7 |
| Number of Residues | 3 |
| Details | binding site for residue PEG H 502 |
| Chain | Residue |
| G | HIS453 |
| H | SER128 |
| H | GLU189 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue PEG H 503 |
| Chain | Residue |
| H | ARG447 |
| H | GLY451 |
| H | SER452 |
| H | HIS453 |
