6FQS

3.11A complex of S.Aureus gyrase with imidazopyrazinone T3 and DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006259	biological_process	DNA metabolic process
A	0006265	biological_process	DNA topological change
B	0003677	molecular_function	DNA binding
B	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B	0005524	molecular_function	ATP binding
B	0006265	biological_process	DNA topological change
C	0003677	molecular_function	DNA binding
C	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
C	0005524	molecular_function	ATP binding
C	0006259	biological_process	DNA metabolic process
C	0006265	biological_process	DNA topological change
D	0003677	molecular_function	DNA binding
D	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
D	0005524	molecular_function	ATP binding
D	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MN B 701

Chain	Residue
B	ASP508
B	ASP510
B	HOH802
B	HOH804
B	HOH805
B	HOH807

---

site_id	AC2
Number of Residues	5
Details	binding site for residue NA A 501

Chain	Residue
A	HOH614
A	HOH626
A	TYR322
A	THR325
A	GLN328

---

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL A 502

Chain	Residue
A	SER112
A	MET113
A	GLN267

---

site_id	AC4
Number of Residues	2
Details	binding site for residue GOL A 503

Chain	Residue
A	ASP138
A	ASN140

---

site_id	AC5
Number of Residues	3
Details	binding site for residue GOL A 504

Chain	Residue
A	GLY255
A	GLN257
C	ASN319

---

site_id	AC6
Number of Residues	3
Details	binding site for residue GOL A 505

Chain	Residue
A	ARG238
A	ILE336
B	ARG630

---

site_id	AC7
Number of Residues	6
Details	binding site for residue MN D 701

Chain	Residue
D	ASP508
D	ASP510
D	HOH801
D	HOH802
D	HOH803
F	HOH104

---

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 C 501

Chain	Residue
A	ARG429
C	ARG429
C	ARG432

---

site_id	AC9
Number of Residues	4
Details	binding site for residue GOL C 502

Chain	Residue
C	ARG47
C	ARG48
C	GLU156
C	PRO157

---

site_id	AD1
Number of Residues	5
Details	binding site for residue GOL C 503

Chain	Residue
A	SER315
A	LEU318
A	ASN319
C	GLU251
C	GLN257

---

site_id	AD2
Number of Residues	3
Details	binding site for residue GOL C 504

Chain	Residue
C	THR290
C	ARG309
C	LYS310

---

site_id	AD3
Number of Residues	3
Details	binding site for residue GOL E 101

Chain	Residue
E	DA-5
E	DG-4
E	DG-6

---

site_id	AD4
Number of Residues	7
Details	binding site for residue E3E E 102

Chain	Residue
A	SER84
B	ARG458
C	ARG122
E	DT-1
E	DG1
F	DC4
F	DA5

---

site_id	AD5
Number of Residues	6
Details	binding site for residue E3E E 103

Chain	Residue
C	SER84
D	ARG458
E	DC4
E	DA5
F	DT-1
F	DG1

---

Functional Information from PROSITE/UniProt

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG

Chain	Residue	Details
B	LEU433-GLY441

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_01897

Chain	Residue	Details
B	ASP510
D	GLU435
D	ASP508
D	ASP510
C	PTR123
B	ASP508

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_01898

Chain	Residue	Details
B	LYS460
B	ASN463
D	LYS460
D	ASN463

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