Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006265 | biological_process | DNA topological change |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006265 | biological_process | DNA topological change |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006259 | biological_process | DNA metabolic process |
| C | 0006265 | biological_process | DNA topological change |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006265 | biological_process | DNA topological change |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MN B 701 |
| Chain | Residue |
| B | ASP508 |
| B | ASP510 |
| B | HOH802 |
| B | HOH804 |
| B | HOH805 |
| B | HOH807 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 501 |
| Chain | Residue |
| A | HOH614 |
| A | HOH626 |
| A | TYR322 |
| A | THR325 |
| A | GLN328 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | SER112 |
| A | MET113 |
| A | GLN267 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | ASP138 |
| A | ASN140 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | GLY255 |
| A | GLN257 |
| C | ASN319 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | ARG238 |
| A | ILE336 |
| B | ARG630 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MN D 701 |
| Chain | Residue |
| D | ASP508 |
| D | ASP510 |
| D | HOH801 |
| D | HOH802 |
| D | HOH803 |
| F | HOH104 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 501 |
| Chain | Residue |
| A | ARG429 |
| C | ARG429 |
| C | ARG432 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 502 |
| Chain | Residue |
| C | ARG47 |
| C | ARG48 |
| C | GLU156 |
| C | PRO157 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 503 |
| Chain | Residue |
| A | SER315 |
| A | LEU318 |
| A | ASN319 |
| C | GLU251 |
| C | GLN257 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 504 |
| Chain | Residue |
| C | THR290 |
| C | ARG309 |
| C | LYS310 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL E 101 |
| Chain | Residue |
| E | DA-5 |
| E | DG-4 |
| E | DG-6 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue E3E E 102 |
| Chain | Residue |
| A | SER84 |
| B | ARG458 |
| C | ARG122 |
| E | DT-1 |
| E | DG1 |
| F | DC4 |
| F | DA5 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue E3E E 103 |
| Chain | Residue |
| C | SER84 |
| D | ARG458 |
| E | DC4 |
| E | DA5 |
| F | DT-1 |
| F | DG1 |
Functional Information from PROSITE/UniProt
| site_id | PS00177 |
| Number of Residues | 9 |
| Details | TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG |
| Chain | Residue | Details |
| B | LEU433-GLY441 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 228 |
| Details | Domain: {"description":"Toprim","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01897","evidenceCode":"ECO:0000255"}]} |
