6FQM
3.06A COMPLEX OF S.AUREUS GYRASE with imidazopyrazinone T1 AND DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006265 | biological_process | DNA topological change |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006265 | biological_process | DNA topological change |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006259 | biological_process | DNA metabolic process |
| C | 0006265 | biological_process | DNA topological change |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006265 | biological_process | DNA topological change |
| a | 0003677 | molecular_function | DNA binding |
| a | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| a | 0005524 | molecular_function | ATP binding |
| a | 0006259 | biological_process | DNA metabolic process |
| a | 0006265 | biological_process | DNA topological change |
| b | 0003677 | molecular_function | DNA binding |
| b | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| b | 0005524 | molecular_function | ATP binding |
| b | 0006265 | biological_process | DNA topological change |
| c | 0003677 | molecular_function | DNA binding |
| c | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| c | 0005524 | molecular_function | ATP binding |
| c | 0006259 | biological_process | DNA metabolic process |
| c | 0006265 | biological_process | DNA topological change |
| d | 0003677 | molecular_function | DNA binding |
| d | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| d | 0005524 | molecular_function | ATP binding |
| d | 0006265 | biological_process | DNA topological change |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MN B 901 |
| Chain | Residue |
| B | ASP508 |
| B | ASP510 |
| B | HOH1003 |
| B | HOH1004 |
| B | HOH1005 |
| F | HOH201 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MN D 901 |
| Chain | Residue |
| D | HOH1003 |
| D | HOH1004 |
| D | HOH1005 |
| D | ASP508 |
| D | ASP510 |
| D | HOH1001 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 1101 |
| Chain | Residue |
| A | ARG429 |
| C | ARG429 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue E32 E 1001 |
| Chain | Residue |
| A | ARG122 |
| A | PTR123 |
| C | SER84 |
| D | ARG458 |
| D | GLY459 |
| D | GLU477 |
| E | DT-1 |
| E | DG1 |
| F | DC4 |
| F | DA5 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL E 1002 |
| Chain | Residue |
| E | DA-5 |
| E | DG-6 |
| E | DG-4 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue E32 E 1003 |
| Chain | Residue |
| A | SER84 |
| B | ARG458 |
| C | ARG122 |
| C | PTR123 |
| E | DC4 |
| E | DA5 |
| F | DT-1 |
| F | DG1 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue E32 F 101 |
| Chain | Residue |
| E | DT11 |
| F | DA-7 |
| F | DG-8 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue MN b 901 |
| Chain | Residue |
| b | GLU435 |
| b | ASP508 |
| b | ASP510 |
| b | HOH1002 |
| b | HOH1003 |
| b | HOH1005 |
| f | HOH1102 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue MN d 901 |
| Chain | Residue |
| d | ASP508 |
| d | ASP510 |
| d | HOH1001 |
| d | HOH1002 |
| d | HOH1003 |
| d | HOH1004 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 c 1101 |
| Chain | Residue |
| c | ARG48 |
| c | PRO80 |
| c | HIS81 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue E32 e 1001 |
| Chain | Residue |
| c | SER84 |
| d | ARG458 |
| e | DT-1 |
| e | DG1 |
| f | DC4 |
| f | DA5 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue E32 f 1001 |
| Chain | Residue |
| a | SER84 |
| b | ARG458 |
| c | ARG122 |
| c | PTR123 |
| e | DC4 |
| e | DA5 |
| f | DT-1 |
| f | DG1 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue E32 f 1002 |
| Chain | Residue |
| e | DT11 |
| f | DG-8 |
| f | DA-7 |
Functional Information from PROSITE/UniProt
| site_id | PS00177 |
| Number of Residues | 9 |
| Details | TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG |
| Chain | Residue | Details |
| D | LEU433-GLY441 | |
| B | LEU433-GLY441 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01897","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
