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6FOL

Domain II of the human copper chaperone in complex with human Cu,Zn superoxide dismutase

Functional Information from GO Data
ChainGOidnamespacecontents
A0005507molecular_functioncopper ion binding
A0006801biological_processsuperoxide metabolic process
A0046872molecular_functionmetal ion binding
B0000303biological_processresponse to superoxide
B0001541biological_processovarian follicle development
B0001819biological_processpositive regulation of cytokine production
B0001890biological_processplacenta development
B0001895biological_processretina homeostasis
B0001975biological_processresponse to amphetamine
B0002262biological_processmyeloid cell homeostasis
B0004784molecular_functionsuperoxide dismutase activity
B0005507molecular_functioncopper ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005758cellular_componentmitochondrial intermembrane space
B0005759cellular_componentmitochondrial matrix
B0005764cellular_componentlysosome
B0005777cellular_componentperoxisome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006749biological_processglutathione metabolic process
B0006801biological_processsuperoxide metabolic process
B0006879biological_processintracellular iron ion homeostasis
B0006979biological_processresponse to oxidative stress
B0007283biological_processspermatogenesis
B0007566biological_processembryo implantation
B0007605biological_processsensory perception of sound
B0007626biological_processlocomotory behavior
B0008089biological_processanterograde axonal transport
B0008090biological_processretrograde axonal transport
B0008217biological_processregulation of blood pressure
B0008270molecular_functionzinc ion binding
B0009408biological_processresponse to heat
B0016209molecular_functionantioxidant activity
B0016491molecular_functionoxidoreductase activity
B0019226biological_processtransmission of nerve impulse
B0019430biological_processremoval of superoxide radicals
B0019899molecular_functionenzyme binding
B0030141cellular_componentsecretory granule
B0030346molecular_functionprotein phosphatase 2B binding
B0031045cellular_componentdense core granule
B0031267molecular_functionsmall GTPase binding
B0031410cellular_componentcytoplasmic vesicle
B0031667biological_processresponse to nutrient levels
B0032287biological_processperipheral nervous system myelin maintenance
B0032839cellular_componentdendrite cytoplasm
B0032930biological_processpositive regulation of superoxide anion generation
B0032991cellular_componentprotein-containing complex
B0033081biological_processregulation of T cell differentiation in thymus
B0034465biological_processresponse to carbon monoxide
B0034599biological_processcellular response to oxidative stress
B0035865biological_processcellular response to potassium ion
B0040014biological_processregulation of multicellular organism growth
B0042542biological_processresponse to hydrogen peroxide
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043025cellular_componentneuronal cell body
B0043065biological_processpositive regulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0043087biological_processregulation of GTPase activity
B0043410biological_processpositive regulation of MAPK cascade
B0043524biological_processnegative regulation of neuron apoptotic process
B0045471biological_processresponse to ethanol
B0046620biological_processregulation of organ growth
B0046688biological_processresponse to copper ion
B0046716biological_processmuscle cell cellular homeostasis
B0046872molecular_functionmetal ion binding
B0048538biological_processthymus development
B0048678biological_processresponse to axon injury
B0050665biological_processhydrogen peroxide biosynthetic process
B0050728biological_processnegative regulation of inflammatory response
B0050766biological_processpositive regulation of phagocytosis
B0051087molecular_functionprotein-folding chaperone binding
B0051881biological_processregulation of mitochondrial membrane potential
B0060047biological_processheart contraction
B0060052biological_processneurofilament cytoskeleton organization
B0060087biological_processrelaxation of vascular associated smooth muscle
B0060088biological_processauditory receptor cell stereocilium organization
B0070062cellular_componentextracellular exosome
B0071276biological_processcellular response to cadmium ion
B0071318biological_processcellular response to ATP
B0072593biological_processreactive oxygen species metabolic process
B0097332biological_processresponse to antipsychotic drug
B1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B1904115cellular_componentaxon cytoplasm
C0000303biological_processresponse to superoxide
C0001541biological_processovarian follicle development
C0001819biological_processpositive regulation of cytokine production
C0001890biological_processplacenta development
C0001895biological_processretina homeostasis
C0001975biological_processresponse to amphetamine
C0002262biological_processmyeloid cell homeostasis
C0004784molecular_functionsuperoxide dismutase activity
C0005507molecular_functioncopper ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005758cellular_componentmitochondrial intermembrane space
C0005759cellular_componentmitochondrial matrix
C0005764cellular_componentlysosome
C0005777cellular_componentperoxisome
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006749biological_processglutathione metabolic process
C0006801biological_processsuperoxide metabolic process
C0006879biological_processintracellular iron ion homeostasis
C0006979biological_processresponse to oxidative stress
C0007283biological_processspermatogenesis
C0007566biological_processembryo implantation
C0007605biological_processsensory perception of sound
C0007626biological_processlocomotory behavior
C0008089biological_processanterograde axonal transport
C0008090biological_processretrograde axonal transport
C0008217biological_processregulation of blood pressure
C0008270molecular_functionzinc ion binding
C0009408biological_processresponse to heat
C0016209molecular_functionantioxidant activity
C0016491molecular_functionoxidoreductase activity
C0019226biological_processtransmission of nerve impulse
C0019430biological_processremoval of superoxide radicals
C0019899molecular_functionenzyme binding
C0030141cellular_componentsecretory granule
C0030346molecular_functionprotein phosphatase 2B binding
C0031045cellular_componentdense core granule
C0031267molecular_functionsmall GTPase binding
C0031410cellular_componentcytoplasmic vesicle
C0031667biological_processresponse to nutrient levels
C0032287biological_processperipheral nervous system myelin maintenance
C0032839cellular_componentdendrite cytoplasm
C0032930biological_processpositive regulation of superoxide anion generation
C0032991cellular_componentprotein-containing complex
C0033081biological_processregulation of T cell differentiation in thymus
C0034465biological_processresponse to carbon monoxide
C0034599biological_processcellular response to oxidative stress
C0035865biological_processcellular response to potassium ion
C0040014biological_processregulation of multicellular organism growth
C0042542biological_processresponse to hydrogen peroxide
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043025cellular_componentneuronal cell body
C0043065biological_processpositive regulation of apoptotic process
C0043066biological_processnegative regulation of apoptotic process
C0043087biological_processregulation of GTPase activity
C0043410biological_processpositive regulation of MAPK cascade
C0043524biological_processnegative regulation of neuron apoptotic process
C0045471biological_processresponse to ethanol
C0046620biological_processregulation of organ growth
C0046688biological_processresponse to copper ion
C0046716biological_processmuscle cell cellular homeostasis
C0046872molecular_functionmetal ion binding
C0048538biological_processthymus development
C0048678biological_processresponse to axon injury
C0050665biological_processhydrogen peroxide biosynthetic process
C0050728biological_processnegative regulation of inflammatory response
C0050766biological_processpositive regulation of phagocytosis
C0051087molecular_functionprotein-folding chaperone binding
C0051881biological_processregulation of mitochondrial membrane potential
C0060047biological_processheart contraction
C0060052biological_processneurofilament cytoskeleton organization
C0060087biological_processrelaxation of vascular associated smooth muscle
C0060088biological_processauditory receptor cell stereocilium organization
C0070062cellular_componentextracellular exosome
C0071276biological_processcellular response to cadmium ion
C0071318biological_processcellular response to ATP
C0072593biological_processreactive oxygen species metabolic process
C0097332biological_processresponse to antipsychotic drug
C1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
C1904115cellular_componentaxon cytoplasm
D0005507molecular_functioncopper ion binding
D0006801biological_processsuperoxide metabolic process
D0046872molecular_functionmetal ion binding
E0005507molecular_functioncopper ion binding
E0006801biological_processsuperoxide metabolic process
E0046872molecular_functionmetal ion binding
F0000303biological_processresponse to superoxide
F0001541biological_processovarian follicle development
F0001819biological_processpositive regulation of cytokine production
F0001890biological_processplacenta development
F0001895biological_processretina homeostasis
F0001975biological_processresponse to amphetamine
F0002262biological_processmyeloid cell homeostasis
F0004784molecular_functionsuperoxide dismutase activity
F0005507molecular_functioncopper ion binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005758cellular_componentmitochondrial intermembrane space
F0005759cellular_componentmitochondrial matrix
F0005764cellular_componentlysosome
F0005777cellular_componentperoxisome
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006749biological_processglutathione metabolic process
F0006801biological_processsuperoxide metabolic process
F0006879biological_processintracellular iron ion homeostasis
F0006979biological_processresponse to oxidative stress
F0007283biological_processspermatogenesis
F0007566biological_processembryo implantation
F0007605biological_processsensory perception of sound
F0007626biological_processlocomotory behavior
F0008089biological_processanterograde axonal transport
F0008090biological_processretrograde axonal transport
F0008217biological_processregulation of blood pressure
F0008270molecular_functionzinc ion binding
F0009408biological_processresponse to heat
F0016209molecular_functionantioxidant activity
F0016491molecular_functionoxidoreductase activity
F0019226biological_processtransmission of nerve impulse
F0019430biological_processremoval of superoxide radicals
F0019899molecular_functionenzyme binding
F0030141cellular_componentsecretory granule
F0030346molecular_functionprotein phosphatase 2B binding
F0031045cellular_componentdense core granule
F0031267molecular_functionsmall GTPase binding
F0031410cellular_componentcytoplasmic vesicle
F0031667biological_processresponse to nutrient levels
F0032287biological_processperipheral nervous system myelin maintenance
F0032839cellular_componentdendrite cytoplasm
F0032930biological_processpositive regulation of superoxide anion generation
F0032991cellular_componentprotein-containing complex
F0033081biological_processregulation of T cell differentiation in thymus
F0034465biological_processresponse to carbon monoxide
F0034599biological_processcellular response to oxidative stress
F0035865biological_processcellular response to potassium ion
F0040014biological_processregulation of multicellular organism growth
F0042542biological_processresponse to hydrogen peroxide
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
F0043025cellular_componentneuronal cell body
F0043065biological_processpositive regulation of apoptotic process
F0043066biological_processnegative regulation of apoptotic process
F0043087biological_processregulation of GTPase activity
F0043410biological_processpositive regulation of MAPK cascade
F0043524biological_processnegative regulation of neuron apoptotic process
F0045471biological_processresponse to ethanol
F0046620biological_processregulation of organ growth
F0046688biological_processresponse to copper ion
F0046716biological_processmuscle cell cellular homeostasis
F0046872molecular_functionmetal ion binding
F0048538biological_processthymus development
F0048678biological_processresponse to axon injury
F0050665biological_processhydrogen peroxide biosynthetic process
F0050728biological_processnegative regulation of inflammatory response
F0050766biological_processpositive regulation of phagocytosis
F0051087molecular_functionprotein-folding chaperone binding
F0051881biological_processregulation of mitochondrial membrane potential
F0060047biological_processheart contraction
F0060052biological_processneurofilament cytoskeleton organization
F0060087biological_processrelaxation of vascular associated smooth muscle
F0060088biological_processauditory receptor cell stereocilium organization
F0070062cellular_componentextracellular exosome
F0071276biological_processcellular response to cadmium ion
F0071318biological_processcellular response to ATP
F0072593biological_processreactive oxygen species metabolic process
F0097332biological_processresponse to antipsychotic drug
F1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
F1904115cellular_componentaxon cytoplasm
G0000303biological_processresponse to superoxide
G0001541biological_processovarian follicle development
G0001819biological_processpositive regulation of cytokine production
G0001890biological_processplacenta development
G0001895biological_processretina homeostasis
G0001975biological_processresponse to amphetamine
G0002262biological_processmyeloid cell homeostasis
G0004784molecular_functionsuperoxide dismutase activity
G0005507molecular_functioncopper ion binding
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005758cellular_componentmitochondrial intermembrane space
G0005759cellular_componentmitochondrial matrix
G0005764cellular_componentlysosome
G0005777cellular_componentperoxisome
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0006749biological_processglutathione metabolic process
G0006801biological_processsuperoxide metabolic process
G0006879biological_processintracellular iron ion homeostasis
G0006979biological_processresponse to oxidative stress
G0007283biological_processspermatogenesis
G0007566biological_processembryo implantation
G0007605biological_processsensory perception of sound
G0007626biological_processlocomotory behavior
G0008089biological_processanterograde axonal transport
G0008090biological_processretrograde axonal transport
G0008217biological_processregulation of blood pressure
G0008270molecular_functionzinc ion binding
G0009408biological_processresponse to heat
G0016209molecular_functionantioxidant activity
G0016491molecular_functionoxidoreductase activity
G0019226biological_processtransmission of nerve impulse
G0019430biological_processremoval of superoxide radicals
G0019899molecular_functionenzyme binding
G0030141cellular_componentsecretory granule
G0030346molecular_functionprotein phosphatase 2B binding
G0031045cellular_componentdense core granule
G0031267molecular_functionsmall GTPase binding
G0031410cellular_componentcytoplasmic vesicle
G0031667biological_processresponse to nutrient levels
G0032287biological_processperipheral nervous system myelin maintenance
G0032839cellular_componentdendrite cytoplasm
G0032930biological_processpositive regulation of superoxide anion generation
G0032991cellular_componentprotein-containing complex
G0033081biological_processregulation of T cell differentiation in thymus
G0034465biological_processresponse to carbon monoxide
G0034599biological_processcellular response to oxidative stress
G0035865biological_processcellular response to potassium ion
G0040014biological_processregulation of multicellular organism growth
G0042542biological_processresponse to hydrogen peroxide
G0042802molecular_functionidentical protein binding
G0042803molecular_functionprotein homodimerization activity
G0043025cellular_componentneuronal cell body
G0043065biological_processpositive regulation of apoptotic process
G0043066biological_processnegative regulation of apoptotic process
G0043087biological_processregulation of GTPase activity
G0043410biological_processpositive regulation of MAPK cascade
G0043524biological_processnegative regulation of neuron apoptotic process
G0045471biological_processresponse to ethanol
G0046620biological_processregulation of organ growth
G0046688biological_processresponse to copper ion
G0046716biological_processmuscle cell cellular homeostasis
G0046872molecular_functionmetal ion binding
G0048538biological_processthymus development
G0048678biological_processresponse to axon injury
G0050665biological_processhydrogen peroxide biosynthetic process
G0050728biological_processnegative regulation of inflammatory response
G0050766biological_processpositive regulation of phagocytosis
G0051087molecular_functionprotein-folding chaperone binding
G0051881biological_processregulation of mitochondrial membrane potential
G0060047biological_processheart contraction
G0060052biological_processneurofilament cytoskeleton organization
G0060087biological_processrelaxation of vascular associated smooth muscle
G0060088biological_processauditory receptor cell stereocilium organization
G0070062cellular_componentextracellular exosome
G0071276biological_processcellular response to cadmium ion
G0071318biological_processcellular response to ATP
G0072593biological_processreactive oxygen species metabolic process
G0097332biological_processresponse to antipsychotic drug
G1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
G1904115cellular_componentaxon cytoplasm
H0005507molecular_functioncopper ion binding
H0006801biological_processsuperoxide metabolic process
H0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 301
ChainResidue
AHIS147
AHIS155
AHIS164
AASP167

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN B 201
ChainResidue
BHIS63
BHIS71
BHIS80
BASP83

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN C 201
ChainResidue
CHIS71
CHIS80
CASP83
CHIS63

site_idAC4
Number of Residues4
Detailsbinding site for residue ZN D 301
ChainResidue
DHIS147
DHIS155
DHIS164
DASP167

site_idAC5
Number of Residues6
Detailsbinding site for residue PE8 D 302
ChainResidue
CLEU38
CASP92
DVAL102
DARG104
DGLU116
DTHR118

site_idAC6
Number of Residues6
Detailsbinding site for residue PE8 D 303
ChainResidue
AASN149
AGLY152
DGLN133
DTYR134
DASN149
DGLY152

site_idAC7
Number of Residues5
Detailsbinding site for residue ZN E 301
ChainResidue
EHIS147
EHIS155
EHIS164
EASP167
EILE217

site_idAC8
Number of Residues4
Detailsbinding site for residue ZN F 201
ChainResidue
FHIS63
FHIS71
FHIS80
FASP83

site_idAC9
Number of Residues6
Detailsbinding site for residue GOL F 202
ChainResidue
FHIS48
FALA57
FALA60
FGLY61
FARG143
FHOH330

site_idAD1
Number of Residues4
Detailsbinding site for residue ZN G 201
ChainResidue
GHIS63
GHIS71
GHIS80
GASP83

site_idAD2
Number of Residues4
Detailsbinding site for residue ZN H 301
ChainResidue
HHIS147
HHIS155
HHIS164
HASP167

Functional Information from PROSITE/UniProt
site_idPS00087
Number of Residues11
DetailsSOD_CU_ZN_1 Copper/Zinc superoxide dismutase signature 1. GFHVHEfGDnT
ChainResidueDetails
BGLY44-THR54

site_idPS00332
Number of Residues12
DetailsSOD_CU_ZN_2 Copper/Zinc superoxide dismutase signature 2. GNSGeRlACgiI
ChainResidueDetails
AGLY219-ILE230

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10677207","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DO5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues12
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"20154138","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"12963370","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17548825","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20727846","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues4
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"1463506","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7002610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues12
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P07632","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues4
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"24140062","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues4
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues4
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"22496122","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues8
DetailsCross-link: {"description":"1-(tryptophan-3-yl)-tryptophan (Trp-Trp) (interchain with W-33)","evidences":[{"source":"PubMed","id":"20600836","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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