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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6FNW

Structure of a volume-regulated anion channel of the LRRC8 family

Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue EDO A 901
ChainResidue
AASN526
ALEU527
ASER528
ASER553
site_idAC2
Number of Residues3
Detailsbinding site for residue EDO A 902
ChainResidue
ALYS645
AARG666
ATYR668
site_idAC3
Number of Residues6
Detailsbinding site for residue EDO A 903
ChainResidue
ASER573
AGLU597
AHOH1016
AHOH1017
AARG550
ALYS571
site_idAC4
Number of Residues3
Detailsbinding site for residue EDO A 904
ChainResidue
AARG403
AGLN404
ASER436
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues11
DetailsRepeat: {"description":"LRR 1","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues22
DetailsRepeat: {"description":"LRR 2","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues21
DetailsRepeat: {"description":"LRR 3","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues23
DetailsRepeat: {"description":"LRR 4","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues22
DetailsRepeat: {"description":"LRR 5","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues24
DetailsRepeat: {"description":"LRR 6","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues22
DetailsRepeat: {"description":"LRR 7","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues22
DetailsRepeat: {"description":"LRR 8","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues23
DetailsRepeat: {"description":"LRR 9","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues23
DetailsRepeat: {"description":"LRR 10","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues22
DetailsRepeat: {"description":"LRR 11","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues22
DetailsRepeat: {"description":"LRR 12","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues21
DetailsRepeat: {"description":"LRR 13","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues22
DetailsRepeat: {"description":"LRR 14","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues21
DetailsRepeat: {"description":"LRR 15","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues22
DetailsRepeat: {"description":"LRR 16","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues23
DetailsRepeat: {"description":"LRR 17","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsMotif: {"description":"Di-leucine motif","evidences":[{"source":"UniProtKB","id":"Q8IWT6","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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