6FM1
Deoxyguanylosuccinate synthase (DgsS) quaternary structure with ATPanddGMP at 2.3 Angstrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004019 | molecular_function | adenylosuccinate synthase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| A | 0046040 | biological_process | IMP metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004019 | molecular_function | adenylosuccinate synthase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| B | 0046040 | biological_process | IMP metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue ATP A 401 |
| Chain | Residue |
| A | GLY13 |
| A | THR44 |
| A | ALA186 |
| A | GLN187 |
| A | ARG269 |
| A | ASN294 |
| A | PHE295 |
| A | ASN297 |
| A | GLY330 |
| A | PRO331 |
| A | DGP402 |
| A | SER14 |
| A | MG403 |
| A | HOH503 |
| A | HOH508 |
| A | THR15 |
| A | GLY16 |
| A | LYS17 |
| A | GLY18 |
| A | ALA41 |
| A | GLY42 |
| A | HIS43 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | binding site for residue DGP A 402 |
| Chain | Residue |
| A | PHE12 |
| A | SER14 |
| A | ASN40 |
| A | ALA41 |
| A | ILE125 |
| A | GLY126 |
| A | SER127 |
| A | THR128 |
| A | GLN187 |
| A | LEU191 |
| A | CYS201 |
| A | THR202 |
| A | VAL236 |
| A | SER240 |
| A | ATP401 |
| A | HOH527 |
| A | HOH535 |
| A | HOH550 |
| A | HOH551 |
| A | HOH605 |
| A | HOH623 |
| B | ARG142 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 403 |
| Chain | Residue |
| A | SER14 |
| A | GLY42 |
| A | THR263 |
| A | ATP401 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 404 |
| Chain | Residue |
| A | ASN28 |
| A | ARG180 |
| A | LYS224 |
| A | TYR326 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | TYR200 |
| A | THR239 |
| A | GLY241 |
| A | GLY242 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 406 |
| Chain | Residue |
| A | ILE87 |
| A | LYS91 |
| A | LEU94 |
| A | ILE100 |
| A | TYR164 |
| A | HOH554 |
| A | HOH603 |
| site_id | AC7 |
| Number of Residues | 25 |
| Details | binding site for residue ATP B 401 |
| Chain | Residue |
| B | GLY13 |
| B | SER14 |
| B | THR15 |
| B | GLY16 |
| B | LYS17 |
| B | GLY18 |
| B | ALA41 |
| B | GLY42 |
| B | HIS43 |
| B | THR44 |
| B | GLN187 |
| B | ASN294 |
| B | PHE295 |
| B | ASN297 |
| B | GLY330 |
| B | PRO331 |
| B | DGP402 |
| B | MG403 |
| B | HOH505 |
| B | HOH528 |
| B | HOH541 |
| B | HOH653 |
| B | HOH671 |
| B | HOH683 |
| B | HOH686 |
| site_id | AC8 |
| Number of Residues | 21 |
| Details | binding site for residue DGP B 402 |
| Chain | Residue |
| B | THR202 |
| B | VAL236 |
| B | SER240 |
| B | ATP401 |
| B | HOH513 |
| B | HOH531 |
| B | HOH542 |
| B | HOH577 |
| B | HOH586 |
| B | HOH604 |
| A | ARG142 |
| B | PHE12 |
| B | SER14 |
| B | ASN40 |
| B | ALA41 |
| B | GLY126 |
| B | SER127 |
| B | THR128 |
| B | GLN187 |
| B | LEU191 |
| B | CYS201 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 403 |
| Chain | Residue |
| B | SER14 |
| B | GLY42 |
| B | ARG269 |
| B | ATP401 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 404 |
| Chain | Residue |
| B | GLU26 |
| B | ASN47 |
| B | TRP53 |
| B | HOH601 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 405 |
| Chain | Residue |
| B | PHE329 |
| B | VAL342 |
| B | HOH558 |
| B | HOH731 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 406 |
| Chain | Residue |
| A | MET1 |
| A | PRO220 |
| B | GLN287 |
| B | PRO288 |
| B | ASP289 |
| B | TYR319 |
| B | ASP321 |
| B | ALA322 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04166","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33926954","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33926955","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6FM1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33926955","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TNH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
