6FKY
Crystal structure of zebrafish Sirtuin 5 in complex with 3-(benzylthio)succinyl-CPS1 peptide
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000035 | molecular_function | acyl binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005829 | cellular_component | cytosol |
A | 0006338 | biological_process | chromatin remodeling |
A | 0006476 | biological_process | protein deacetylation |
A | 0008270 | molecular_function | zinc ion binding |
A | 0010566 | biological_process | regulation of ketone biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
A | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
A | 0034979 | molecular_function | NAD-dependent protein lysine deacetylase activity |
A | 0036047 | biological_process | peptidyl-lysine demalonylation |
A | 0036048 | biological_process | protein desuccinylation |
A | 0036049 | biological_process | peptidyl-lysine desuccinylation |
A | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
A | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0061697 | molecular_function | protein-glutaryllysine deglutarylase activity |
A | 0070403 | molecular_function | NAD+ binding |
A | 1901363 | molecular_function | heterocyclic compound binding |
B | 0000035 | molecular_function | acyl binding |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005829 | cellular_component | cytosol |
B | 0006338 | biological_process | chromatin remodeling |
B | 0006476 | biological_process | protein deacetylation |
B | 0008270 | molecular_function | zinc ion binding |
B | 0010566 | biological_process | regulation of ketone biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
B | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
B | 0034979 | molecular_function | NAD-dependent protein lysine deacetylase activity |
B | 0036047 | biological_process | peptidyl-lysine demalonylation |
B | 0036048 | biological_process | protein desuccinylation |
B | 0036049 | biological_process | peptidyl-lysine desuccinylation |
B | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
B | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
B | 0046872 | molecular_function | metal ion binding |
B | 0061697 | molecular_function | protein-glutaryllysine deglutarylase activity |
B | 0070403 | molecular_function | NAD+ binding |
B | 1901363 | molecular_function | heterocyclic compound binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 401 |
Chain | Residue |
A | CYS162 |
A | CYS165 |
A | CYS203 |
A | CYS208 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue ZN B 401 |
Chain | Residue |
B | CYS162 |
B | CYS165 |
B | CYS203 |
B | CYS208 |
site_id | AC3 |
Number of Residues | 11 |
Details | binding site for residue EPE B 402 |
Chain | Residue |
B | ALA78 |
B | ALA82 |
B | TYR98 |
B | ARG101 |
B | HIS154 |
B | VAL217 |
B | TRP218 |
B | PHE219 |
B | GLU221 |
B | TYR251 |
A | GLU232 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue NA B 403 |
Chain | Residue |
B | ASP224 |
B | ASP224 |
B | ASP226 |
B | ASP226 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue EDO B 404 |
Chain | Residue |
B | SER58 |
B | GLN136 |
B | ASN137 |
B | ASP139 |
site_id | AC6 |
Number of Residues | 13 |
Details | binding site for residue DZK I 101 |
Chain | Residue |
A | ALA55 |
A | THR65 |
A | ARG67 |
A | ALA78 |
A | ALA82 |
A | TYR98 |
A | ARG101 |
A | ILE138 |
A | HIS154 |
A | VAL217 |
C | LYS4 |
C | E9N101 |
I | LYS4 |
site_id | AC7 |
Number of Residues | 12 |
Details | binding site for Di-peptide GZB C 1 and VAL C 2 |
Chain | Residue |
A | THR222 |
A | LEU223 |
A | LEU228 |
B | LEU228 |
B | MET255 |
B | GLN259 |
C | LEU3 |
C | LYS4 |
I | GZB1 |
I | VAL2 |
I | LEU3 |
I | LYS4 |
site_id | AC8 |
Number of Residues | 24 |
Details | binding site for Di-peptide E9N C 101 and LYS C 4 |
Chain | Residue |
A | ALA55 |
A | THR65 |
A | ALA82 |
A | TYR98 |
A | ARG101 |
A | GLN136 |
A | ASN137 |
A | ILE138 |
A | HIS154 |
A | VAL216 |
A | VAL217 |
A | GLU221 |
C | VAL2 |
C | LEU3 |
C | GLU5 |
C | TYR6 |
C | GLY7 |
I | VAL2 |
I | LEU3 |
I | LYS4 |
I | GLU5 |
I | TYR6 |
I | GLY7 |
I | DZK101 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236 |
Chain | Residue | Details |
A | HIS154 | |
B | HIS154 |
site_id | SWS_FT_FI2 |
Number of Residues | 22 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03160 |
Chain | Residue | Details |
A | ARG101 | |
A | GLN136 | |
A | CYS162 | |
A | CYS165 | |
A | CYS203 | |
A | CYS208 | |
A | GLY245 | |
A | ASN271 | |
A | CYS289 | |
B | GLY54 | |
B | TYR98 | |
B | ARG101 | |
B | GLN136 | |
B | CYS162 | |
B | CYS165 | |
B | CYS203 | |
B | CYS208 | |
B | GLY245 | |
B | ASN271 | |
B | CYS289 | |
A | GLY54 | |
A | TYR98 |