6FKY

Crystal structure of zebrafish Sirtuin 5 in complex with 3-(benzylthio)succinyl-CPS1 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000035	molecular_function	acyl binding
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006338	biological_process	chromatin remodeling
A	0006476	biological_process	protein deacetylation
A	0008270	molecular_function	zinc ion binding
A	0010566	biological_process	regulation of ketone biosynthetic process
A	0016740	molecular_function	transferase activity
A	0017136	molecular_function	histone deacetylase activity, NAD-dependent
A	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
A	0036047	biological_process	peptidyl-lysine demalonylation
A	0036048	biological_process	protein desuccinylation
A	0036049	biological_process	peptidyl-lysine desuccinylation
A	0036054	molecular_function	protein-malonyllysine demalonylase activity
A	0036055	molecular_function	protein-succinyllysine desuccinylase activity
A	0046872	molecular_function	metal ion binding
A	0061697	molecular_function	protein-glutaryllysine deglutarylase activity
A	0070403	molecular_function	NAD+ binding
A	1901363	molecular_function	heterocyclic compound binding
B	0000035	molecular_function	acyl binding
B	0005634	cellular_component	nucleus
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006338	biological_process	chromatin remodeling
B	0006476	biological_process	protein deacetylation
B	0008270	molecular_function	zinc ion binding
B	0010566	biological_process	regulation of ketone biosynthetic process
B	0016740	molecular_function	transferase activity
B	0017136	molecular_function	histone deacetylase activity, NAD-dependent
B	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
B	0036047	biological_process	peptidyl-lysine demalonylation
B	0036048	biological_process	protein desuccinylation
B	0036049	biological_process	peptidyl-lysine desuccinylation
B	0036054	molecular_function	protein-malonyllysine demalonylase activity
B	0036055	molecular_function	protein-succinyllysine desuccinylase activity
B	0046872	molecular_function	metal ion binding
B	0061697	molecular_function	protein-glutaryllysine deglutarylase activity
B	0070403	molecular_function	NAD+ binding
B	1901363	molecular_function	heterocyclic compound binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	CYS162
A	CYS165
A	CYS203
A	CYS208

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN B 401

Chain	Residue
B	CYS162
B	CYS165
B	CYS203
B	CYS208

---

site_id	AC3
Number of Residues	11
Details	binding site for residue EPE B 402

Chain	Residue
B	ALA78
B	ALA82
B	TYR98
B	ARG101
B	HIS154
B	VAL217
B	TRP218
B	PHE219
B	GLU221
B	TYR251
A	GLU232

---

site_id	AC4
Number of Residues	4
Details	binding site for residue NA B 403

Chain	Residue
B	ASP224
B	ASP224
B	ASP226
B	ASP226

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO B 404

Chain	Residue
B	SER58
B	GLN136
B	ASN137
B	ASP139

---

site_id	AC6
Number of Residues	13
Details	binding site for residue DZK I 101

Chain	Residue
A	ALA55
A	THR65
A	ARG67
A	ALA78
A	ALA82
A	TYR98
A	ARG101
A	ILE138
A	HIS154
A	VAL217
C	LYS4
C	E9N101
I	LYS4

---

site_id	AC7
Number of Residues	12
Details	binding site for Di-peptide GZB C 1 and VAL C 2

Chain	Residue
A	THR222
A	LEU223
A	LEU228
B	LEU228
B	MET255
B	GLN259
C	LEU3
C	LYS4
I	GZB1
I	VAL2
I	LEU3
I	LYS4

---

site_id	AC8
Number of Residues	24
Details	binding site for Di-peptide E9N C 101 and LYS C 4

Chain	Residue
A	ALA55
A	THR65
A	ALA82
A	TYR98
A	ARG101
A	GLN136
A	ASN137
A	ILE138
A	HIS154
A	VAL216
A	VAL217
A	GLU221
C	VAL2
C	LEU3
C	GLU5
C	TYR6
C	GLY7
I	VAL2
I	LEU3
I	LYS4
I	GLU5
I	TYR6
I	GLY7
I	DZK101

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	66
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03160","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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