6FIZ
Crystal Structure of CNG mimicking NaK-EAPP mutant (T67A) cocrystallized with K+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| C | 0005267 | molecular_function | potassium channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0071805 | biological_process | potassium ion transmembrane transport |
| D | 0005267 | molecular_function | potassium channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0071805 | biological_process | potassium ion transmembrane transport |
| E | 0005267 | molecular_function | potassium channel activity |
| E | 0016020 | cellular_component | membrane |
| E | 0071805 | biological_process | potassium ion transmembrane transport |
| F | 0005267 | molecular_function | potassium channel activity |
| F | 0016020 | cellular_component | membrane |
| F | 0071805 | biological_process | potassium ion transmembrane transport |
| G | 0005267 | molecular_function | potassium channel activity |
| G | 0016020 | cellular_component | membrane |
| G | 0071805 | biological_process | potassium ion transmembrane transport |
| H | 0005267 | molecular_function | potassium channel activity |
| H | 0016020 | cellular_component | membrane |
| H | 0071805 | biological_process | potassium ion transmembrane transport |
| I | 0005267 | molecular_function | potassium channel activity |
| I | 0016020 | cellular_component | membrane |
| I | 0071805 | biological_process | potassium ion transmembrane transport |
| J | 0005267 | molecular_function | potassium channel activity |
| J | 0016020 | cellular_component | membrane |
| J | 0071805 | biological_process | potassium ion transmembrane transport |
| K | 0005267 | molecular_function | potassium channel activity |
| K | 0016020 | cellular_component | membrane |
| K | 0071805 | biological_process | potassium ion transmembrane transport |
| L | 0005267 | molecular_function | potassium channel activity |
| L | 0016020 | cellular_component | membrane |
| L | 0071805 | biological_process | potassium ion transmembrane transport |
| M | 0005267 | molecular_function | potassium channel activity |
| M | 0016020 | cellular_component | membrane |
| M | 0071805 | biological_process | potassium ion transmembrane transport |
| N | 0005267 | molecular_function | potassium channel activity |
| N | 0016020 | cellular_component | membrane |
| N | 0071805 | biological_process | potassium ion transmembrane transport |
| O | 0005267 | molecular_function | potassium channel activity |
| O | 0016020 | cellular_component | membrane |
| O | 0071805 | biological_process | potassium ion transmembrane transport |
| P | 0005267 | molecular_function | potassium channel activity |
| P | 0016020 | cellular_component | membrane |
| P | 0071805 | biological_process | potassium ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue GLY A 202 |
| Chain | Residue |
| A | ILE32 |
| B | PHE84 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue K A 203 |
| Chain | Residue |
| A | THR63 |
| B | THR63 |
| C | THR63 |
| D | THR63 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue K A 204 |
| Chain | Residue |
| B | VAL64 |
| C | THR63 |
| C | VAL64 |
| C | HOH303 |
| D | THR63 |
| D | VAL64 |
| A | THR63 |
| A | VAL64 |
| B | THR63 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue K A 205 |
| Chain | Residue |
| A | GLY65 |
| B | GLY65 |
| C | GLY65 |
| C | HOH303 |
| D | GLY65 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue GLY B 201 |
| Chain | Residue |
| B | PRO68 |
| B | PRO69 |
| B | GLN71 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue GLY B 202 |
| Chain | Residue |
| B | ASP52 |
| B | PRO68 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue GLY B 203 |
| Chain | Residue |
| B | GLN71 |
| J | SER108 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue GLY C 201 |
| Chain | Residue |
| C | PHE56 |
| C | PRO68 |
| C | PRO69 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue GLY D 201 |
| Chain | Residue |
| D | PHE56 |
| D | PRO68 |
| D | PRO69 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue GLY D 202 |
| Chain | Residue |
| A | PRO69 |
| D | LEU48 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue GLY D 203 |
| Chain | Residue |
| D | VAL101 |
| D | GLN102 |
| D | SER105 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue GLY D 204 |
| Chain | Residue |
| D | VAL45 |
| L | VAL110 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue MPD D 205 |
| Chain | Residue |
| D | SER37 |
| D | PHE78 |
| I | LEU33 |
| I | ILE36 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue GLY E 201 |
| Chain | Residue |
| E | ASP52 |
| E | GLY202 |
| F | PRO69 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue GLY E 202 |
| Chain | Residue |
| E | GLU46 |
| E | LEU48 |
| E | PHE56 |
| E | PRO68 |
| E | PRO69 |
| E | PRO70 |
| E | GLY201 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue GLY E 203 |
| Chain | Residue |
| E | ASP73 |
| H | ARG49 |
| O | VAL111 |
| O | PRO112 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue K E 205 |
| Chain | Residue |
| E | THR63 |
| F | THR63 |
| G | THR63 |
| H | THR63 |
| site_id | AD9 |
| Number of Residues | 9 |
| Details | binding site for residue K E 206 |
| Chain | Residue |
| E | THR63 |
| E | VAL64 |
| F | THR63 |
| F | VAL64 |
| G | THR63 |
| G | VAL64 |
| G | HOH303 |
| H | THR63 |
| H | VAL64 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue K E 207 |
| Chain | Residue |
| E | GLY65 |
| F | GLY65 |
| G | GLY65 |
| G | HOH303 |
| H | GLY65 |
| site_id | AE2 |
| Number of Residues | 1 |
| Details | binding site for residue GLY F 201 |
| Chain | Residue |
| F | GLY202 |
| site_id | AE3 |
| Number of Residues | 2 |
| Details | binding site for residue GLY F 202 |
| Chain | Residue |
| F | PRO69 |
| F | GLY201 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue MPD F 203 |
| Chain | Residue |
| F | SER37 |
| F | PHE78 |
| F | ILE85 |
| K | LEU33 |
| K | ILE36 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue GLY G 201 |
| Chain | Residue |
| G | PHE56 |
| G | PRO68 |
| G | GLY202 |
| site_id | AE6 |
| Number of Residues | 2 |
| Details | binding site for residue GLY G 202 |
| Chain | Residue |
| G | GLY201 |
| H | PRO69 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue MPD G 203 |
| Chain | Residue |
| G | ILE32 |
| G | PHE93 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue GLY H 201 |
| Chain | Residue |
| H | LEU48 |
| H | PHE56 |
| H | PRO68 |
| H | PRO69 |
| H | GLY202 |
| site_id | AE9 |
| Number of Residues | 1 |
| Details | binding site for residue GLY H 202 |
| Chain | Residue |
| H | GLY201 |
| site_id | AF1 |
| Number of Residues | 2 |
| Details | binding site for residue GLY H 203 |
| Chain | Residue |
| H | PHE28 |
| H | ILE32 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue GLY H 204 |
| Chain | Residue |
| H | THR34 |
| H | SER37 |
| M | ILE36 |
| M | GLY204 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue GLY I 201 |
| Chain | Residue |
| I | GLN102 |
| I | ILE106 |
| I | HOH303 |
| site_id | AF4 |
| Number of Residues | 1 |
| Details | binding site for residue GLY I 202 |
| Chain | Residue |
| I | VAL26 |
| site_id | AF5 |
| Number of Residues | 1 |
| Details | binding site for residue GLY I 203 |
| Chain | Residue |
| I | SER37 |
| site_id | AF6 |
| Number of Residues | 5 |
| Details | binding site for residue K I 204 |
| Chain | Residue |
| I | THR63 |
| I | K205 |
| J | THR63 |
| K | THR63 |
| L | THR63 |
| site_id | AF7 |
| Number of Residues | 10 |
| Details | binding site for residue K I 205 |
| Chain | Residue |
| I | THR63 |
| I | VAL64 |
| I | K204 |
| J | THR63 |
| J | VAL64 |
| K | THR63 |
| K | VAL64 |
| K | HOH304 |
| L | THR63 |
| L | VAL64 |
| site_id | AF8 |
| Number of Residues | 5 |
| Details | binding site for residue K I 206 |
| Chain | Residue |
| I | GLY65 |
| J | GLY65 |
| K | GLY65 |
| K | HOH304 |
| L | GLY65 |
| site_id | AF9 |
| Number of Residues | 2 |
| Details | binding site for residue GLY J 201 |
| Chain | Residue |
| J | SER37 |
| J | PHE78 |
| site_id | AG1 |
| Number of Residues | 2 |
| Details | binding site for residue GLY J 202 |
| Chain | Residue |
| J | LEU33 |
| J | GLY203 |
| site_id | AG2 |
| Number of Residues | 2 |
| Details | binding site for residue GLY J 203 |
| Chain | Residue |
| J | SER37 |
| J | GLY202 |
| site_id | AG3 |
| Number of Residues | 3 |
| Details | binding site for residue GLY J 204 |
| Chain | Residue |
| J | ALA98 |
| J | LEU103 |
| K | GLY88 |
| site_id | AG4 |
| Number of Residues | 1 |
| Details | binding site for residue GLY J 205 |
| Chain | Residue |
| J | PRO69 |
| site_id | AG5 |
| Number of Residues | 1 |
| Details | binding site for residue GLY J 206 |
| Chain | Residue |
| J | GLY88 |
| site_id | AG6 |
| Number of Residues | 2 |
| Details | binding site for residue GLY J 207 |
| Chain | Residue |
| J | GLU23 |
| J | VAL26 |
| site_id | AG7 |
| Number of Residues | 1 |
| Details | binding site for residue GLY J 208 |
| Chain | Residue |
| J | LEU103 |
| site_id | AG8 |
| Number of Residues | 2 |
| Details | binding site for residue GLY J 209 |
| Chain | Residue |
| F | GLN71 |
| J | PRO112 |
| site_id | AG9 |
| Number of Residues | 4 |
| Details | binding site for residue MPD J 210 |
| Chain | Residue |
| J | PHE28 |
| J | ILE32 |
| K | LEU81 |
| K | PHE84 |
| site_id | AH1 |
| Number of Residues | 3 |
| Details | binding site for residue MPD J 211 |
| Chain | Residue |
| I | PHE28 |
| I | PHE93 |
| J | ILE85 |
| site_id | AH2 |
| Number of Residues | 2 |
| Details | binding site for residue GLY K 201 |
| Chain | Residue |
| K | ASP52 |
| K | ALA67 |
| site_id | AH3 |
| Number of Residues | 4 |
| Details | binding site for residue GLY K 202 |
| Chain | Residue |
| K | LEU103 |
| K | LEU107 |
| L | GLU23 |
| L | LEU27 |
| site_id | AH4 |
| Number of Residues | 2 |
| Details | binding site for residue GLY K 203 |
| Chain | Residue |
| K | PHE93 |
| K | HOH303 |
| site_id | AH5 |
| Number of Residues | 3 |
| Details | binding site for residue GLY L 201 |
| Chain | Residue |
| I | LEU89 |
| L | ALA98 |
| L | LEU103 |
| site_id | AH6 |
| Number of Residues | 3 |
| Details | binding site for residue GLY L 202 |
| Chain | Residue |
| L | LEU107 |
| P | LEU107 |
| P | VAL110 |
| site_id | AH7 |
| Number of Residues | 3 |
| Details | binding site for residue GLY M 202 |
| Chain | Residue |
| C | ASP73 |
| M | SER108 |
| M | VAL111 |
| site_id | AH8 |
| Number of Residues | 5 |
| Details | binding site for residue GLY M 204 |
| Chain | Residue |
| H | LEU81 |
| H | ILE85 |
| H | GLY204 |
| M | LEU33 |
| M | ILE36 |
| site_id | AH9 |
| Number of Residues | 1 |
| Details | binding site for residue GLY M 205 |
| Chain | Residue |
| G | SER105 |
| site_id | AI1 |
| Number of Residues | 2 |
| Details | binding site for residue GLY M 206 |
| Chain | Residue |
| M | GLU23 |
| M | VAL26 |
| site_id | AI2 |
| Number of Residues | 5 |
| Details | binding site for residue K M 207 |
| Chain | Residue |
| M | THR63 |
| M | K208 |
| N | THR63 |
| O | THR63 |
| P | THR63 |
| site_id | AI3 |
| Number of Residues | 10 |
| Details | binding site for residue K M 208 |
| Chain | Residue |
| M | THR63 |
| M | VAL64 |
| M | K207 |
| M | HOH302 |
| N | THR63 |
| N | VAL64 |
| O | THR63 |
| O | VAL64 |
| P | THR63 |
| P | VAL64 |
| site_id | AI4 |
| Number of Residues | 5 |
| Details | binding site for residue K M 209 |
| Chain | Residue |
| M | GLY65 |
| M | HOH302 |
| N | GLY65 |
| O | GLY65 |
| P | GLY65 |
| site_id | AI5 |
| Number of Residues | 3 |
| Details | binding site for residue MPD M 210 |
| Chain | Residue |
| M | ILE32 |
| M | HOH304 |
| N | LEU81 |
| site_id | AI6 |
| Number of Residues | 2 |
| Details | binding site for residue GLY N 201 |
| Chain | Residue |
| M | ALA98 |
| N | GLY88 |
| site_id | AI7 |
| Number of Residues | 3 |
| Details | binding site for residue GLY N 202 |
| Chain | Residue |
| N | PHE56 |
| N | PRO68 |
| N | PRO69 |
| site_id | AI8 |
| Number of Residues | 1 |
| Details | binding site for residue GLY N 203 |
| Chain | Residue |
| N | SER37 |
| site_id | AI9 |
| Number of Residues | 1 |
| Details | binding site for residue GLY N 204 |
| Chain | Residue |
| N | ALA98 |
| site_id | AJ1 |
| Number of Residues | 2 |
| Details | binding site for residue GLY N 205 |
| Chain | Residue |
| C | ILE85 |
| N | LEU33 |
| site_id | AJ2 |
| Number of Residues | 2 |
| Details | binding site for residue GLY N 206 |
| Chain | Residue |
| N | HIS95 |
| O | GLY88 |
| site_id | AJ3 |
| Number of Residues | 2 |
| Details | binding site for residue MPD N 209 |
| Chain | Residue |
| N | ILE32 |
| O | PHE84 |
| site_id | AJ4 |
| Number of Residues | 1 |
| Details | binding site for residue GLY O 201 |
| Chain | Residue |
| O | ASP52 |
| site_id | AJ5 |
| Number of Residues | 4 |
| Details | binding site for residue GLY O 202 |
| Chain | Residue |
| A | SER105 |
| A | SER108 |
| O | SER43 |
| O | LEU48 |
| site_id | AJ6 |
| Number of Residues | 1 |
| Details | binding site for residue GLY O 203 |
| Chain | Residue |
| O | GLU23 |
| site_id | AJ7 |
| Number of Residues | 1 |
| Details | binding site for residue GLY O 204 |
| Chain | Residue |
| O | SER37 |
| site_id | AJ8 |
| Number of Residues | 3 |
| Details | binding site for residue GLY P 201 |
| Chain | Residue |
| P | SER37 |
| P | PHE78 |
| P | ILE85 |
| site_id | AJ9 |
| Number of Residues | 3 |
| Details | binding site for residue GLY P 202 |
| Chain | Residue |
| P | LEU48 |
| P | PRO68 |
| P | PRO69 |
| site_id | AK1 |
| Number of Residues | 1 |
| Details | binding site for residue GLY P 203 |
| Chain | Residue |
| P | SER37 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | Region: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"P29973","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Site: {"description":"Central gate","evidences":[{"source":"UniProtKB","id":"P29973","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
