6FIJ
Structure of the loading/condensing region (SAT-KS-MAT) of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| B | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1401 |
| Chain | Residue |
| A | ASP18 |
| A | TYR74 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1402 |
| Chain | Residue |
| A | ARG285 |
| A | SER290 |
| A | ALA298 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1403 |
| Chain | Residue |
| A | LYS1102 |
| A | ALA288 |
| A | ARG315 |
| A | SER319 |
| A | ASN322 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1404 |
| Chain | Residue |
| A | ARG392 |
| A | GLU447 |
| A | LEU472 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1405 |
| Chain | Residue |
| A | GLY1069 |
| A | GLU1070 |
| A | GLU1073 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1406 |
| Chain | Residue |
| A | PHE393 |
| A | GLN395 |
| A | SER396 |
| A | TRP444 |
| A | LEU445 |
| A | HIS446 |
| A | GLU447 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 1407 |
| Chain | Residue |
| A | THR647 |
| A | ASN648 |
| A | GLN670 |
| B | ASN497 |
| B | GLU571 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 1408 |
| Chain | Residue |
| A | MET316 |
| A | SER340 |
| A | PHE341 |
| A | LEU345 |
| A | GLN348 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 1401 |
| Chain | Residue |
| B | ALA433 |
| B | LYS434 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 1402 |
| Chain | Residue |
| B | ARG392 |
| B | GLU447 |
| B | LEU472 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 1403 |
| Chain | Residue |
| A | VAL519 |
| B | VAL436 |
| B | ALA590 |
| B | ASP593 |
| B | ALA594 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 1404 |
| Chain | Residue |
| B | ARG490 |
| B | ALA633 |
| B | TYR869 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 1405 |
| Chain | Residue |
| B | TRP421 |
| B | HIS426 |
| B | VAL427 |
| B | SER437 |
| B | THR439 |
| B | GLY440 |
| B | PRO586 |
| B | THR589 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 1406 |
| Chain | Residue |
| A | LYS47 |
| B | ASP630 |
| B | ASP634 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 1407 |
| Chain | Residue |
| B | THR196 |
| B | THR196 |
| B | ALA197 |
| B | ALA197 |
| B | GLN199 |
| B | GLN199 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue DTT B 1408 |
| Chain | Residue |
| B | LEU313 |
| B | MET316 |
| B | ALA317 |
| B | PHE341 |
| B | LYS344 |
| B | LEU345 |
| B | GLN348 |
Functional Information from PROSITE/UniProt
| site_id | PS00606 |
| Number of Residues | 17 |
| Details | KS3_1 Ketosynthase family 3 (KS3) active site signature. GPSytIDtACSSSlaAL |
| Chain | Residue | Details |
| A | GLY544-LEU560 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 866 |
| Details | Domain: {"description":"Ketosynthase family 3 (KS3)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15915645","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23108075","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29610486","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 478 |
| Details | Region: {"description":"N-terminal acylcarrier protein transacylase domain (SAT)","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15915645","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23108075","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29610486","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 602 |
| Details | Region: {"description":"Malonyl-CoA:ACP transacylase (MAT) domain","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15915645","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23108075","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29610486","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Active site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
