6FE8

Cryo-EM structure of the core Centromere Binding Factor 3 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000775	cellular_component	chromosome, centromeric region
A	0000776	cellular_component	kinetochore
A	0000921	biological_process	septin ring assembly
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0007094	biological_process	mitotic spindle assembly checkpoint signaling
A	0008270	molecular_function	zinc ion binding
A	0008301	molecular_function	DNA binding, bending
A	0019237	molecular_function	centromeric DNA binding
A	0031518	cellular_component	CBF3 complex
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0051382	biological_process	kinetochore assembly
B	0000775	cellular_component	chromosome, centromeric region
B	0000776	cellular_component	kinetochore
B	0000921	biological_process	septin ring assembly
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0007094	biological_process	mitotic spindle assembly checkpoint signaling
B	0008270	molecular_function	zinc ion binding
B	0008301	molecular_function	DNA binding, bending
B	0019237	molecular_function	centromeric DNA binding
B	0031518	cellular_component	CBF3 complex
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0051382	biological_process	kinetochore assembly
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0000086	biological_process	G2/M transition of mitotic cell cycle
C	0000278	biological_process	mitotic cell cycle
C	0000409	biological_process	regulation of transcription by galactose
C	0000775	cellular_component	chromosome, centromeric region
C	0000776	cellular_component	kinetochore
C	0000781	cellular_component	chromosome, telomeric region
C	0000921	biological_process	septin ring assembly
C	0003677	molecular_function	DNA binding
C	0003688	molecular_function	DNA replication origin binding
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0007035	biological_process	vacuolar acidification
C	0007096	biological_process	regulation of exit from mitosis
C	0007346	biological_process	regulation of mitotic cell cycle
C	0008053	biological_process	mitochondrial fusion
C	0010458	biological_process	exit from mitosis
C	0010828	biological_process	positive regulation of glucose transmembrane transport
C	0012505	cellular_component	endomembrane system
C	0016567	biological_process	protein ubiquitination
C	0019005	cellular_component	SCF ubiquitin ligase complex
C	0019222	biological_process	regulation of metabolic process
C	0030466	biological_process	silent mating-type cassette heterochromatin formation
C	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C	0031335	biological_process	regulation of sulfur amino acid metabolic process
C	0031509	biological_process	subtelomeric heterochromatin formation
C	0031518	cellular_component	CBF3 complex
C	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
C	0043254	biological_process	regulation of protein-containing complex assembly
C	0043291	cellular_component	RAVE complex
C	0045116	biological_process	protein neddylation
C	0051382	biological_process	kinetochore assembly
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0065003	biological_process	protein-containing complex assembly
C	0070072	biological_process	vacuolar proton-transporting V-type ATPase complex assembly
C	0071406	biological_process	cellular response to methylmercury
C	0097602	molecular_function	cullin family protein binding
C	2000766	biological_process	negative regulation of cytoplasmic translation
D	0000775	cellular_component	chromosome, centromeric region
D	0000776	cellular_component	kinetochore
D	0000921	biological_process	septin ring assembly
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0008301	molecular_function	DNA binding, bending
D	0031518	cellular_component	CBF3 complex
D	0051382	biological_process	kinetochore assembly

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
C	THR177
B	SER575

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