6FDY

Unc-51-Like Kinase 3 (ULK3) In Complex With Bosutinib

Functional Information from GO Data

Chain	GOid	namespace	contents
U	0004672	molecular_function	protein kinase activity
U	0004674	molecular_function	protein serine/threonine kinase activity
U	0005524	molecular_function	ATP binding
U	0006468	biological_process	protein phosphorylation
U	0010506	biological_process	regulation of autophagy

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue DB8 U 301

Chain	Residue
U	LEU20
U	HOH485
U	ALA42
U	VAL75
U	MET91
U	GLU92
U	CYS94
U	ASN142
U	LEU144
U	ASP157

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site_id	AC2
Number of Residues	10
Details	binding site for residue DB8 U 302

Chain	Residue
U	LEU173
U	LEU173
U	GLY175
U	MET180
U	MET180
U	PHE218
U	SER219
U	GLU222
U	HOH432
U	HOH494

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	30
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGTYATVYkAyakkdtrevvaikc....VAKK

Chain	Residue	Details
U	LEU20-LYS49

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IsHlDLKpqNILL

Chain	Residue	Details
U	ILE133-LEU145

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
U	ASP137

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
U	LEU20
U	LYS44

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976

Chain	Residue	Details
U	SER176

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