6FC7
Crystal Structure of Two-Domain Laccase mutant H165F from Streptomyces griseoflavus with high copper ions occupancy
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005507 | molecular_function | copper ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006826 | biological_process | iron ion transport |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| B | 0005507 | molecular_function | copper ion binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006826 | biological_process | iron ion transport |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| C | 0005507 | molecular_function | copper ion binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006826 | biological_process | iron ion transport |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| D | 0005507 | molecular_function | copper ion binding |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006826 | biological_process | iron ion transport |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| E | 0005507 | molecular_function | copper ion binding |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006826 | biological_process | iron ion transport |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| F | 0005507 | molecular_function | copper ion binding |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0006826 | biological_process | iron ion transport |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| G | 0005507 | molecular_function | copper ion binding |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0006826 | biological_process | iron ion transport |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| H | 0005507 | molecular_function | copper ion binding |
| H | 0005886 | cellular_component | plasma membrane |
| H | 0006826 | biological_process | iron ion transport |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| I | 0005507 | molecular_function | copper ion binding |
| I | 0005886 | cellular_component | plasma membrane |
| I | 0006826 | biological_process | iron ion transport |
| I | 0016491 | molecular_function | oxidoreductase activity |
| I | 0046872 | molecular_function | metal ion binding |
| I | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| J | 0005507 | molecular_function | copper ion binding |
| J | 0005886 | cellular_component | plasma membrane |
| J | 0006826 | biological_process | iron ion transport |
| J | 0016491 | molecular_function | oxidoreductase activity |
| J | 0046872 | molecular_function | metal ion binding |
| J | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| K | 0005507 | molecular_function | copper ion binding |
| K | 0005886 | cellular_component | plasma membrane |
| K | 0006826 | biological_process | iron ion transport |
| K | 0016491 | molecular_function | oxidoreductase activity |
| K | 0046872 | molecular_function | metal ion binding |
| K | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| L | 0005507 | molecular_function | copper ion binding |
| L | 0005886 | cellular_component | plasma membrane |
| L | 0006826 | biological_process | iron ion transport |
| L | 0016491 | molecular_function | oxidoreductase activity |
| L | 0046872 | molecular_function | metal ion binding |
| L | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue CU A 401 |
| Chain | Residue |
| A | HIS232 |
| A | CYS289 |
| A | HIS294 |
| A | MET299 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CU A 402 |
| Chain | Residue |
| A | HIS237 |
| A | HIS288 |
| A | HOH540 |
| C | HIS159 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CU A 403 |
| Chain | Residue |
| C | HIS103 |
| C | HOH511 |
| A | HIS235 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CU A 404 |
| Chain | Residue |
| A | HIS105 |
| A | HIS157 |
| B | HIS290 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CU A 405 |
| Chain | Residue |
| A | HIS103 |
| A | HIS105 |
| A | HOH507 |
| B | HIS235 |
| B | HIS237 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue CU B 401 |
| Chain | Residue |
| B | HIS232 |
| B | CYS289 |
| B | HIS294 |
| B | MET299 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue CU A 406 |
| Chain | Residue |
| A | HIS159 |
| A | HOH530 |
| B | HIS237 |
| B | HIS288 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue CU B 402 |
| Chain | Residue |
| B | HIS105 |
| B | HIS157 |
| B | PER403 |
| C | HIS290 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | binding site for residue PER B 403 |
| Chain | Residue |
| B | HIS103 |
| B | HIS105 |
| B | HIS157 |
| B | HIS159 |
| B | CU402 |
| B | HOH522 |
| C | HIS288 |
| C | HIS290 |
| B | CU405 |
| B | CU406 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 404 |
| Chain | Residue |
| B | ARG50 |
| B | VAL52 |
| B | GLU81 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue CU A 407 |
| Chain | Residue |
| A | HIS290 |
| A | HOH540 |
| C | HIS103 |
| C | HIS105 |
| C | HIS157 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue CU C 401 |
| Chain | Residue |
| C | HIS232 |
| C | CYS289 |
| C | HIS294 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue CU B 405 |
| Chain | Residue |
| B | HIS159 |
| B | PER403 |
| C | HIS237 |
| C | HIS288 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue CU B 406 |
| Chain | Residue |
| B | HIS103 |
| B | HIS105 |
| B | PER403 |
| C | HIS235 |
| C | HIS237 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue CU D 401 |
| Chain | Residue |
| D | HIS232 |
| D | CYS289 |
| D | HIS294 |
| D | MET299 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue CU D 402 |
| Chain | Residue |
| D | HIS237 |
| D | HIS288 |
| F | HIS159 |
| D | PER409 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue CU D 403 |
| Chain | Residue |
| D | HIS235 |
| D | HIS237 |
| F | HIS103 |
| F | HIS105 |
| D | PER409 |
| F | HOH504 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue CU D 404 |
| Chain | Residue |
| D | HIS103 |
| D | HIS105 |
| D | HIS157 |
| E | HIS290 |
| D | OXY407 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue CU E 401 |
| Chain | Residue |
| E | HIS232 |
| E | CYS289 |
| E | HIS294 |
| E | MET299 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue CU D 405 |
| Chain | Residue |
| D | HIS159 |
| E | HIS237 |
| E | HIS288 |
| D | OXY407 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue CU D 406 |
| Chain | Residue |
| D | HIS103 |
| E | HIS235 |
| E | HIS237 |
| D | OXY407 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue CU E 402 |
| Chain | Residue |
| E | HIS105 |
| E | HIS157 |
| F | HIS290 |
| E | PER405 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue CU E 403 |
| Chain | Residue |
| F | HIS235 |
| F | HIS237 |
| E | PER405 |
| E | HIS103 |
| E | HIS105 |
| E | HOH517 |
| site_id | AE6 |
| Number of Residues | 11 |
| Details | binding site for residue OXY D 407 |
| Chain | Residue |
| D | HIS103 |
| D | HIS157 |
| D | HIS159 |
| D | CU404 |
| E | HIS235 |
| E | HIS237 |
| E | HIS288 |
| E | HIS290 |
| D | CU405 |
| D | CU406 |
| D | HOH513 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue CU D 408 |
| Chain | Residue |
| D | HIS290 |
| F | HIS103 |
| F | HIS105 |
| F | HIS157 |
| D | PER409 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue CU F 401 |
| Chain | Residue |
| F | HIS232 |
| F | CYS289 |
| F | HIS294 |
| F | MET299 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue CU E 404 |
| Chain | Residue |
| E | HIS159 |
| F | HIS237 |
| F | HIS288 |
| E | PER405 |
| site_id | AF1 |
| Number of Residues | 11 |
| Details | binding site for residue PER D 409 |
| Chain | Residue |
| D | HIS235 |
| D | HIS288 |
| D | HIS290 |
| D | CU402 |
| D | CU403 |
| F | HIS103 |
| F | HIS105 |
| F | HIS157 |
| F | HIS159 |
| D | CU408 |
| F | HOH517 |
| site_id | AF2 |
| Number of Residues | 11 |
| Details | binding site for residue PER E 405 |
| Chain | Residue |
| E | HIS103 |
| E | HIS105 |
| E | HIS157 |
| E | HIS159 |
| E | CU402 |
| E | CU403 |
| F | HIS235 |
| F | HIS288 |
| F | HIS290 |
| E | CU404 |
| E | HOH501 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue CU G 401 |
| Chain | Residue |
| G | HIS232 |
| G | CYS289 |
| G | HIS294 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue CU G 402 |
| Chain | Residue |
| G | HIS237 |
| G | HIS288 |
| I | HIS159 |
| I | HOH524 |
| site_id | AF5 |
| Number of Residues | 4 |
| Details | binding site for residue CU G 403 |
| Chain | Residue |
| G | HIS235 |
| G | HIS237 |
| I | HIS103 |
| I | HIS105 |
| site_id | AF6 |
| Number of Residues | 5 |
| Details | binding site for residue CU G 404 |
| Chain | Residue |
| G | HIS103 |
| G | HIS105 |
| G | HIS157 |
| G | PER406 |
| H | HIS290 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue CU G 405 |
| Chain | Residue |
| G | HIS103 |
| G | HIS105 |
| G | PER406 |
| G | HOH502 |
| H | HIS235 |
| H | HIS237 |
| site_id | AF8 |
| Number of Residues | 11 |
| Details | binding site for residue PER G 406 |
| Chain | Residue |
| G | HIS103 |
| G | HIS105 |
| G | HIS157 |
| G | HIS159 |
| G | CU404 |
| G | CU405 |
| G | HOH534 |
| H | HIS237 |
| H | HIS288 |
| H | HIS290 |
| G | CU407 |
| site_id | AF9 |
| Number of Residues | 4 |
| Details | binding site for residue CU H 401 |
| Chain | Residue |
| H | HIS232 |
| H | CYS289 |
| H | HIS294 |
| H | MET299 |
| site_id | AG1 |
| Number of Residues | 4 |
| Details | binding site for residue CU G 407 |
| Chain | Residue |
| G | HIS159 |
| G | PER406 |
| H | HIS237 |
| H | HIS288 |
| site_id | AG2 |
| Number of Residues | 5 |
| Details | binding site for residue CU H 402 |
| Chain | Residue |
| H | HIS103 |
| H | HIS105 |
| H | HIS157 |
| I | HIS290 |
| I | HOH530 |
| site_id | AG3 |
| Number of Residues | 4 |
| Details | binding site for residue CU G 408 |
| Chain | Residue |
| G | HIS290 |
| I | HIS105 |
| I | HIS157 |
| I | HOH524 |
| site_id | AG4 |
| Number of Residues | 4 |
| Details | binding site for residue CU I 401 |
| Chain | Residue |
| I | HIS232 |
| I | CYS289 |
| I | HIS294 |
| I | MET299 |
| site_id | AG5 |
| Number of Residues | 4 |
| Details | binding site for residue CU H 403 |
| Chain | Residue |
| H | HIS159 |
| I | HIS237 |
| I | HIS288 |
| I | HOH530 |
| site_id | AG6 |
| Number of Residues | 4 |
| Details | binding site for residue CU H 404 |
| Chain | Residue |
| H | HIS103 |
| H | HOH508 |
| I | HIS235 |
| I | HIS237 |
| site_id | AG7 |
| Number of Residues | 4 |
| Details | binding site for residue CU J 401 |
| Chain | Residue |
| J | HIS232 |
| J | CYS289 |
| J | HIS294 |
| J | MET299 |
| site_id | AG8 |
| Number of Residues | 4 |
| Details | binding site for residue CU J 402 |
| Chain | Residue |
| J | HIS237 |
| J | HIS288 |
| J | OXY405 |
| L | HIS159 |
| site_id | AG9 |
| Number of Residues | 5 |
| Details | binding site for residue CU J 403 |
| Chain | Residue |
| J | HIS235 |
| J | HIS237 |
| J | OXY405 |
| L | HIS103 |
| L | HOH525 |
| site_id | AH1 |
| Number of Residues | 4 |
| Details | binding site for residue CU J 404 |
| Chain | Residue |
| J | HIS105 |
| J | HIS157 |
| J | PER406 |
| K | HIS290 |
| site_id | AH2 |
| Number of Residues | 11 |
| Details | binding site for residue OXY J 405 |
| Chain | Residue |
| J | HIS235 |
| J | HIS288 |
| J | HIS290 |
| J | CU402 |
| J | CU403 |
| J | HOH504 |
| L | HIS103 |
| L | HIS105 |
| L | HIS157 |
| L | HIS159 |
| J | CU409 |
| site_id | AH3 |
| Number of Residues | 10 |
| Details | binding site for residue PER J 406 |
| Chain | Residue |
| J | HIS103 |
| J | HIS105 |
| J | HIS157 |
| J | HIS159 |
| J | CU404 |
| J | HOH543 |
| K | HIS237 |
| K | HIS288 |
| K | HIS290 |
| J | CU407 |
| site_id | AH4 |
| Number of Residues | 4 |
| Details | binding site for residue CU K 401 |
| Chain | Residue |
| K | HIS232 |
| K | CYS289 |
| K | HIS294 |
| K | MET299 |
| site_id | AH5 |
| Number of Residues | 4 |
| Details | binding site for residue CU J 407 |
| Chain | Residue |
| J | HIS159 |
| J | PER406 |
| K | HIS237 |
| K | HIS288 |
| site_id | AH6 |
| Number of Residues | 4 |
| Details | binding site for residue CU J 408 |
| Chain | Residue |
| J | HIS103 |
| J | HOH510 |
| K | HIS235 |
| K | HIS237 |
| site_id | AH7 |
| Number of Residues | 4 |
| Details | binding site for residue CU K 402 |
| Chain | Residue |
| K | HIS105 |
| K | HIS157 |
| K | PER403 |
| L | HIS290 |
| site_id | AH8 |
| Number of Residues | 12 |
| Details | binding site for residue PER K 403 |
| Chain | Residue |
| K | HIS103 |
| K | HIS105 |
| K | HIS157 |
| K | HIS159 |
| K | CU402 |
| K | HOH513 |
| L | HIS235 |
| L | HIS237 |
| L | HIS288 |
| L | HIS290 |
| K | CU404 |
| K | CU405 |
| site_id | AH9 |
| Number of Residues | 4 |
| Details | binding site for residue CU J 409 |
| Chain | Residue |
| J | HIS290 |
| J | OXY405 |
| L | HIS105 |
| L | HIS157 |
| site_id | AI1 |
| Number of Residues | 4 |
| Details | binding site for residue CU L 401 |
| Chain | Residue |
| L | HIS232 |
| L | CYS289 |
| L | HIS294 |
| L | MET299 |
| site_id | AI2 |
| Number of Residues | 4 |
| Details | binding site for residue CU K 404 |
| Chain | Residue |
| K | HIS159 |
| K | PER403 |
| L | HIS237 |
| L | HIS288 |
| site_id | AI3 |
| Number of Residues | 5 |
| Details | binding site for residue CU K 405 |
| Chain | Residue |
| K | HIS103 |
| K | PER403 |
| K | HOH516 |
| L | HIS235 |
| L | HIS237 |
Functional Information from PROSITE/UniProt
| site_id | PS00080 |
| Number of Residues | 12 |
| Details | MULTICOPPER_OXIDASE2 Multicopper oxidases signature 2. HCHvqsHsdmGM |
| Chain | Residue | Details |
| A | HIS288-MET299 |
