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6FBW

Crystal structure of C-terminal modified Tau peptide-hybrid 4.2f-II with 14-3-3sigma

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001836biological_processrelease of cytochrome c from mitochondria
A0003334biological_processkeratinocyte development
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006469biological_processnegative regulation of protein kinase activity
A0006611biological_processprotein export from nucleus
A0007165biological_processsignal transduction
A0008104biological_processprotein localization
A0008426molecular_functionprotein kinase C inhibitor activity
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0010482biological_processregulation of epidermal cell division
A0010839biological_processnegative regulation of keratinocyte proliferation
A0019901molecular_functionprotein kinase binding
A0022407biological_processregulation of cell-cell adhesion
A0030216biological_processkeratinocyte differentiation
A0030307biological_processpositive regulation of cell growth
A0031424biological_processkeratinization
A0032880biological_processregulation of protein localization
A0042802molecular_functionidentical protein binding
A0043588biological_processskin development
A0043616biological_processkeratinocyte proliferation
A0045296molecular_functioncadherin binding
A0045606biological_processpositive regulation of epidermal cell differentiation
A0045785biological_processpositive regulation of cell adhesion
A0045824biological_processnegative regulation of innate immune response
A0046827biological_processpositive regulation of protein export from nucleus
A0050815molecular_functionphosphoserine residue binding
A0051219molecular_functionphosphoprotein binding
A0051726biological_processregulation of cell cycle
A0061436biological_processestablishment of skin barrier
A0070062cellular_componentextracellular exosome
A0072089biological_processstem cell proliferation
A0140311molecular_functionprotein sequestering activity
A0141156biological_processcAMP/PKA signal transduction
A1903077biological_processnegative regulation of protein localization to plasma membrane
A1903829biological_processpositive regulation of protein localization
A2000647biological_processnegative regulation of stem cell proliferation
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001836biological_processrelease of cytochrome c from mitochondria
C0003334biological_processkeratinocyte development
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006469biological_processnegative regulation of protein kinase activity
C0006611biological_processprotein export from nucleus
C0007165biological_processsignal transduction
C0008104biological_processprotein localization
C0008426molecular_functionprotein kinase C inhibitor activity
C0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
C0010482biological_processregulation of epidermal cell division
C0010839biological_processnegative regulation of keratinocyte proliferation
C0019901molecular_functionprotein kinase binding
C0022407biological_processregulation of cell-cell adhesion
C0030216biological_processkeratinocyte differentiation
C0030307biological_processpositive regulation of cell growth
C0031424biological_processkeratinization
C0032880biological_processregulation of protein localization
C0042802molecular_functionidentical protein binding
C0043588biological_processskin development
C0043616biological_processkeratinocyte proliferation
C0045296molecular_functioncadherin binding
C0045606biological_processpositive regulation of epidermal cell differentiation
C0045785biological_processpositive regulation of cell adhesion
C0045824biological_processnegative regulation of innate immune response
C0046827biological_processpositive regulation of protein export from nucleus
C0050815molecular_functionphosphoserine residue binding
C0051219molecular_functionphosphoprotein binding
C0051726biological_processregulation of cell cycle
C0061436biological_processestablishment of skin barrier
C0070062cellular_componentextracellular exosome
C0072089biological_processstem cell proliferation
C0140311molecular_functionprotein sequestering activity
C0141156biological_processcAMP/PKA signal transduction
C1903077biological_processnegative regulation of protein localization to plasma membrane
C1903829biological_processpositive regulation of protein localization
C2000647biological_processnegative regulation of stem cell proliferation
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue CL A 301
ChainResidue
AHOH701
AHOH703
CLYS9

site_idAC2
Number of Residues6
Detailsbinding site for residue NA A 302
ChainResidue
ALEU36
AARG41
ASER116
ATYR120
AHOH416
AHOH486

site_idAC3
Number of Residues6
Detailsbinding site for residue NA A 303
ChainResidue
ATHR228
ATHR231
AHOH463
AHOH639
AHOH658
AHOH720

site_idAC4
Number of Residues5
Detailsbinding site for residue NA A 304
ChainResidue
AGLN8
AHOH589
CGLU80
CHOH439
CHOH598

site_idAC5
Number of Residues6
Detailsbinding site for residue NA A 305
ChainResidue
AGLY-1
AHOH483
AHOH586
CGLU2
CHOH471
CHOH658

site_idAC6
Number of Residues7
Detailsbinding site for residue D4K B 101
ChainResidue
AASN42
ASER45
AVAL46
BLEU6
BGLY8
CMET202
CHIS206

site_idAC7
Number of Residues3
Detailsbinding site for residue CL C 301
ChainResidue
ALYS9
CHOH608
CHOH668

site_idAC8
Number of Residues16
Detailsbinding site for Di-peptide PRO D 4 and SEP D 5
ChainResidue
CLYS49
CARG56
CARG129
CTYR130
CASN175
CVAL178
CASN226
DTHR3
DLEU6
DPRO7
DHOH201
DHOH203
DHOH204
DHOH205
DHOH206
DHOH207

site_idAC9
Number of Residues17
Detailsbinding site for Di-peptide SEP D 5 and LEU D 6
ChainResidue
CLYS49
CARG56
CARG129
CTYR130
CLEU174
CASN175
DTHR3
DPRO4
DPRO7
DGLY8
DD4K101
DHOH201
DHOH203
DHOH204
DHOH205
DHOH206
DHOH207

site_idAD1
Number of Residues7
Detailsbinding site for Di-peptide D4K D 101 and GLY D 8
ChainResidue
CASN42
CSER45
CVAL46
CHOH472
CHOH557
DLEU6
DPRO7

Functional Information from PROSITE/UniProt
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
AARG41-VAL51

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by BRSK1, BRSK2, DYRK2 and PDPK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:9614189
ChainResidueDetails
BTHR3
DTHR3
CARG56
CARG129

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189
ChainResidueDetails
BSEP5
DSEP5

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER74
CSER74

226707

PDB entries from 2024-10-30

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