Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6FAD

SR protein kinase 1 (SRPK1) in complex with the RGG-box of HSV1 ICP27

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000245	biological_process	spliceosomal complex assembly
A	0000287	molecular_function	magnesium ion binding
A	0000785	cellular_component	chromatin
A	0003723	molecular_function	RNA binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006397	biological_process	mRNA processing
A	0006468	biological_process	protein phosphorylation
A	0007059	biological_process	chromosome segregation
A	0008380	biological_process	RNA splicing
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016363	cellular_component	nuclear matrix
A	0016607	cellular_component	nuclear speck
A	0016740	molecular_function	transferase activity
A	0030154	biological_process	cell differentiation
A	0035092	biological_process	sperm DNA condensation
A	0035556	biological_process	intracellular signal transduction
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0045070	biological_process	positive regulation of viral genome replication
A	0045071	biological_process	negative regulation of viral genome replication
A	0045087	biological_process	innate immune response
A	0048024	biological_process	regulation of mRNA splicing, via spliceosome
A	0050684	biological_process	regulation of mRNA processing
A	0106310	molecular_function	protein serine kinase activity
B	0000166	molecular_function	nucleotide binding
B	0000245	biological_process	spliceosomal complex assembly
B	0000287	molecular_function	magnesium ion binding
B	0000785	cellular_component	chromatin
B	0003723	molecular_function	RNA binding
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006397	biological_process	mRNA processing
B	0006468	biological_process	protein phosphorylation
B	0007059	biological_process	chromosome segregation
B	0008380	biological_process	RNA splicing
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0016363	cellular_component	nuclear matrix
B	0016607	cellular_component	nuclear speck
B	0016740	molecular_function	transferase activity
B	0030154	biological_process	cell differentiation
B	0035092	biological_process	sperm DNA condensation
B	0035556	biological_process	intracellular signal transduction
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0045070	biological_process	positive regulation of viral genome replication
B	0045071	biological_process	negative regulation of viral genome replication
B	0045087	biological_process	innate immune response
B	0048024	biological_process	regulation of mRNA splicing, via spliceosome
B	0050684	biological_process	regulation of mRNA processing
B	0106310	molecular_function	protein serine kinase activity
C	0000166	molecular_function	nucleotide binding
C	0000245	biological_process	spliceosomal complex assembly
C	0000287	molecular_function	magnesium ion binding
C	0000785	cellular_component	chromatin
C	0003723	molecular_function	RNA binding
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006397	biological_process	mRNA processing
C	0006468	biological_process	protein phosphorylation
C	0007059	biological_process	chromosome segregation
C	0008380	biological_process	RNA splicing
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0016363	cellular_component	nuclear matrix
C	0016607	cellular_component	nuclear speck
C	0016740	molecular_function	transferase activity
C	0030154	biological_process	cell differentiation
C	0035092	biological_process	sperm DNA condensation
C	0035556	biological_process	intracellular signal transduction
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0045070	biological_process	positive regulation of viral genome replication
C	0045071	biological_process	negative regulation of viral genome replication
C	0045087	biological_process	innate immune response
C	0048024	biological_process	regulation of mRNA splicing, via spliceosome
C	0050684	biological_process	regulation of mRNA processing
C	0106310	molecular_function	protein serine kinase activity
D	0000166	molecular_function	nucleotide binding
D	0000245	biological_process	spliceosomal complex assembly
D	0000287	molecular_function	magnesium ion binding
D	0000785	cellular_component	chromatin
D	0003723	molecular_function	RNA binding
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006397	biological_process	mRNA processing
D	0006468	biological_process	protein phosphorylation
D	0007059	biological_process	chromosome segregation
D	0008380	biological_process	RNA splicing
D	0016301	molecular_function	kinase activity
D	0016310	biological_process	phosphorylation
D	0016363	cellular_component	nuclear matrix
D	0016607	cellular_component	nuclear speck
D	0016740	molecular_function	transferase activity
D	0030154	biological_process	cell differentiation
D	0035092	biological_process	sperm DNA condensation
D	0035556	biological_process	intracellular signal transduction
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0045070	biological_process	positive regulation of viral genome replication
D	0045071	biological_process	negative regulation of viral genome replication
D	0045087	biological_process	innate immune response
D	0048024	biological_process	regulation of mRNA splicing, via spliceosome
D	0050684	biological_process	regulation of mRNA processing
D	0106310	molecular_function	protein serine kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue PO4 A 701

Chain	Residue
A	HIS554
A	SER555
A	ARG561
D	HIS554

site_id	AC2
Number of Residues	3
Details	binding site for residue PO4 A 702

Chain	Residue
A	ARG515
A	ARG518
A	ARG561

site_id	AC3
Number of Residues	4
Details	binding site for residue PO4 B 701

Chain	Residue
B	ARG561
B	HOH825
B	ARG515
B	ARG518

site_id	AC4
Number of Residues	4
Details	binding site for residue PO4 B 702

Chain	Residue
B	ARG132
B	ASN133
D	ARG132
D	ASN133

site_id	AC5
Number of Residues	11
Details	binding site for Di-peptide PO4 C 701 and ARG C 132

Chain	Residue
A	ARG132
A	ASN133
C	LEU128
C	LYS129
C	SER130
C	VAL131
C	ASN133
C	SER134
C	ARG141
C	LEU147
C	HOH810

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGWGHFSTVWlSwdiqgkkf..........VAMK

Chain	Residue	Details
A	LEU86-LYS109

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHtDIKpeNILL

Chain	Residue	Details
A	ILE209-LEU221

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	MOD_RES: Dimethylated arginine; by host => ECO:0000305\|PubMed:19321610

Chain	Residue	Details
E	ARG138
E	ARG150
F	ARG138
F	ARG150
G	ARG138
G	ARG150
H	ARG138
H	ARG150

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Omega-N-methylarginine; by host => ECO:0000305\|PubMed:19321610

Chain	Residue	Details
E	ARG148
D	LEU86
D	LYS109
D	GLU166
F	ARG148
G	ARG148
H	ARG148
B	LYS109
B	GLU166
C	LEU86
C	LYS109
C	GLU166

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000269\|PubMed:12565829, ECO:0007744\|PubMed:17081983, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:18691976, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER51
B	SER51
C	SER51
D	SER51

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER309
A	SER311
B	SER309
B	SER311
C	SER309
C	SER311
D	SER309
D	SER311

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER333
B	SER333
C	SER333
D	SER333

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000269\|PubMed:12565829

Chain	Residue	Details
A	SER555
B	SER555
C	SER555
D	SER555

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)