6F8U
Crystal structure of the PDE4D catalytic domain in complex with GEBR-20b
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue ZN A 601 |
| Chain | Residue |
| A | HIS330 |
| A | HIS366 |
| A | ASP367 |
| A | ASP484 |
| A | MG602 |
| A | HOH769 |
| A | HOH871 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 602 |
| Chain | Residue |
| A | HOH769 |
| A | HOH778 |
| A | HOH796 |
| A | HOH868 |
| A | HOH890 |
| A | ASP367 |
| A | ZN601 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 603 |
| Chain | Residue |
| A | HOH737 |
| A | HOH931 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 604 |
| Chain | Residue |
| A | ASP467 |
| A | ASP471 |
| A | HIS527 |
| A | HOH750 |
| A | HOH803 |
| A | HOH815 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 605 |
| Chain | Residue |
| B | HOH726 |
| B | HOH770 |
| B | HOH783 |
| B | HOH880 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | binding site for residue CZQ A 606 |
| Chain | Residue |
| A | SER374 |
| A | ASN487 |
| A | PRO488 |
| A | TYR495 |
| A | TRP498 |
| A | THR499 |
| A | ILE502 |
| A | PHE506 |
| A | GLN509 |
| A | PRO522 |
| A | MET523 |
| A | GLN535 |
| A | PHE538 |
| A | HOH732 |
| A | HOH759 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue ZN B 601 |
| Chain | Residue |
| B | HIS330 |
| B | HIS366 |
| B | ASP367 |
| B | ASP484 |
| B | MG602 |
| B | HOH753 |
| B | HOH787 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue MG B 602 |
| Chain | Residue |
| B | ASP367 |
| B | ZN601 |
| B | HOH753 |
| B | HOH765 |
| B | HOH777 |
| B | HOH800 |
| B | HOH815 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | binding site for residue CZQ B 603 |
| Chain | Residue |
| B | TYR325 |
| B | MET439 |
| B | ASN487 |
| B | TYR495 |
| B | TRP498 |
| B | THR499 |
| B | ILE502 |
| B | MET503 |
| B | PHE506 |
| B | MET523 |
| B | GLN535 |
| B | PHE538 |
| B | ILE542 |
| B | CZQ604 |
| site_id | AD1 |
| Number of Residues | 17 |
| Details | binding site for residue CZQ B 604 |
| Chain | Residue |
| B | TYR325 |
| B | SER374 |
| B | ASN487 |
| B | PRO488 |
| B | TYR495 |
| B | TRP498 |
| B | THR499 |
| B | ILE502 |
| B | MET503 |
| B | PHE506 |
| B | PRO522 |
| B | MET523 |
| B | SER534 |
| B | GLN535 |
| B | PHE538 |
| B | CZQ603 |
| B | HOH873 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF |
| Chain | Residue | Details |
| A | HIS366-PHE377 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q07343","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17582435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PW3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17582435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PW3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
