6F7H
Crystal structure of human AQP10
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005811 | cellular_component | lipid droplet |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006833 | biological_process | water transport |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0015204 | molecular_function | urea transmembrane transporter activity |
| A | 0015250 | molecular_function | water channel activity |
| A | 0015254 | molecular_function | glycerol channel activity |
| A | 0015267 | molecular_function | channel activity |
| A | 0015793 | biological_process | glycerol transmembrane transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0051289 | biological_process | protein homotetramerization |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071918 | biological_process | urea transmembrane transport |
| B | 0005515 | molecular_function | protein binding |
| B | 0005811 | cellular_component | lipid droplet |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006833 | biological_process | water transport |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0015204 | molecular_function | urea transmembrane transporter activity |
| B | 0015250 | molecular_function | water channel activity |
| B | 0015254 | molecular_function | glycerol channel activity |
| B | 0015267 | molecular_function | channel activity |
| B | 0015793 | biological_process | glycerol transmembrane transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0051289 | biological_process | protein homotetramerization |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0071918 | biological_process | urea transmembrane transport |
| C | 0005515 | molecular_function | protein binding |
| C | 0005811 | cellular_component | lipid droplet |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006833 | biological_process | water transport |
| C | 0009636 | biological_process | response to toxic substance |
| C | 0015204 | molecular_function | urea transmembrane transporter activity |
| C | 0015250 | molecular_function | water channel activity |
| C | 0015254 | molecular_function | glycerol channel activity |
| C | 0015267 | molecular_function | channel activity |
| C | 0015793 | biological_process | glycerol transmembrane transport |
| C | 0016020 | cellular_component | membrane |
| C | 0016323 | cellular_component | basolateral plasma membrane |
| C | 0016324 | cellular_component | apical plasma membrane |
| C | 0051289 | biological_process | protein homotetramerization |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0071918 | biological_process | urea transmembrane transport |
| D | 0005515 | molecular_function | protein binding |
| D | 0005811 | cellular_component | lipid droplet |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006833 | biological_process | water transport |
| D | 0009636 | biological_process | response to toxic substance |
| D | 0015204 | molecular_function | urea transmembrane transporter activity |
| D | 0015250 | molecular_function | water channel activity |
| D | 0015254 | molecular_function | glycerol channel activity |
| D | 0015267 | molecular_function | channel activity |
| D | 0015793 | biological_process | glycerol transmembrane transport |
| D | 0016020 | cellular_component | membrane |
| D | 0016323 | cellular_component | basolateral plasma membrane |
| D | 0016324 | cellular_component | apical plasma membrane |
| D | 0051289 | biological_process | protein homotetramerization |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0071918 | biological_process | urea transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00221 |
| Number of Residues | 9 |
| Details | MIP MIP family signature. HLNPAFSLA |
| Chain | Residue | Details |
| A | HIS80-ALA88 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 72 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"30420639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6F7H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 272 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30420639","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 76 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"30420639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6F7H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 68 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30420639","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 104 |
| Details | Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"30420639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6F7H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 96 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"30420639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6F7H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 68 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"30420639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6F7H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 64 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"30420639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6F7H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"30420639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6F7H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | Motif: {"description":"NPA 1","evidences":[{"source":"PubMed","id":"30420639","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | Motif: {"description":"NPA 2","evidences":[{"source":"PubMed","id":"30420639","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Site: {"description":"pH-sensor","evidences":[{"source":"PubMed","id":"30420639","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21733844","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
