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6F7H

Crystal structure of human AQP10

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005811cellular_componentlipid droplet
A0005886cellular_componentplasma membrane
A0006833biological_processwater transport
A0009636biological_processresponse to toxic substance
A0015204molecular_functionurea transmembrane transporter activity
A0015250molecular_functionwater channel activity
A0015254molecular_functionglycerol channel activity
A0015267molecular_functionchannel activity
A0015791biological_processpolyol transmembrane transport
A0015793biological_processglycerol transmembrane transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0043231cellular_componentintracellular membrane-bounded organelle
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0071468biological_processcellular response to acidic pH
A0071918biological_processurea transmembrane transport
B0005515molecular_functionprotein binding
B0005811cellular_componentlipid droplet
B0005886cellular_componentplasma membrane
B0006833biological_processwater transport
B0009636biological_processresponse to toxic substance
B0015204molecular_functionurea transmembrane transporter activity
B0015250molecular_functionwater channel activity
B0015254molecular_functionglycerol channel activity
B0015267molecular_functionchannel activity
B0015791biological_processpolyol transmembrane transport
B0015793biological_processglycerol transmembrane transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0043231cellular_componentintracellular membrane-bounded organelle
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0071468biological_processcellular response to acidic pH
B0071918biological_processurea transmembrane transport
C0005515molecular_functionprotein binding
C0005811cellular_componentlipid droplet
C0005886cellular_componentplasma membrane
C0006833biological_processwater transport
C0009636biological_processresponse to toxic substance
C0015204molecular_functionurea transmembrane transporter activity
C0015250molecular_functionwater channel activity
C0015254molecular_functionglycerol channel activity
C0015267molecular_functionchannel activity
C0015791biological_processpolyol transmembrane transport
C0015793biological_processglycerol transmembrane transport
C0016020cellular_componentmembrane
C0016323cellular_componentbasolateral plasma membrane
C0016324cellular_componentapical plasma membrane
C0043231cellular_componentintracellular membrane-bounded organelle
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0071468biological_processcellular response to acidic pH
C0071918biological_processurea transmembrane transport
D0005515molecular_functionprotein binding
D0005811cellular_componentlipid droplet
D0005886cellular_componentplasma membrane
D0006833biological_processwater transport
D0009636biological_processresponse to toxic substance
D0015204molecular_functionurea transmembrane transporter activity
D0015250molecular_functionwater channel activity
D0015254molecular_functionglycerol channel activity
D0015267molecular_functionchannel activity
D0015791biological_processpolyol transmembrane transport
D0015793biological_processglycerol transmembrane transport
D0016020cellular_componentmembrane
D0016323cellular_componentbasolateral plasma membrane
D0016324cellular_componentapical plasma membrane
D0043231cellular_componentintracellular membrane-bounded organelle
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0071468biological_processcellular response to acidic pH
D0071918biological_processurea transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00221
Number of Residues9
DetailsMIP MIP family signature. HLNPAFSLA
ChainResidueDetails
AHIS80-ALA88

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues308
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:30420639
ChainResidueDetails
AMET1-LEU25
BALA265-LEU301
CMET1-LEU25
CGLY74-SER77
CVAL92-TRP97
CLEU178-ALA187
CALA265-LEU301
DMET1-LEU25
DGLY74-SER77
DVAL92-TRP97
DLEU178-ALA187
AGLY74-SER77
DALA265-LEU301
AVAL92-TRP97
ALEU178-ALA187
AALA265-LEU301
BMET1-LEU25
BGLY74-SER77
BVAL92-TRP97
BLEU178-ALA187

site_idSWS_FT_FI2
Number of Residues492
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:30420639
ChainResidueDetails
AALA26-VAL46
BASN157-ILE177
BGLY188-ALA207
BVAL244-VAL264
CALA26-VAL46
CGLY53-GLY73
CVAL98-TYR122
CASN157-ILE177
CGLY188-ALA207
CVAL244-VAL264
DALA26-VAL46
AGLY53-GLY73
DGLY53-GLY73
DVAL98-TYR122
DASN157-ILE177
DGLY188-ALA207
DVAL244-VAL264
AVAL98-TYR122
AASN157-ILE177
AGLY188-ALA207
AVAL244-VAL264
BALA26-VAL46
BGLY53-GLY73
BVAL98-TYR122

site_idSWS_FT_FI3
Number of Residues216
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:30420639
ChainResidueDetails
ATHR47-LYS52
DTHR47-LYS52
DHIS123-LEU156
DVAL227-TRP243
AHIS123-LEU156
AVAL227-TRP243
BTHR47-LYS52
BHIS123-LEU156
BVAL227-TRP243
CTHR47-LYS52
CHIS123-LEU156
CVAL227-TRP243

site_idSWS_FT_FI4
Number of Residues124
DetailsINTRAMEM: Discontinuously helical => ECO:0000269|PubMed:30420639
ChainResidueDetails
AGLY78-ILE91
AASN208-TYR226
BGLY78-ILE91
BASN208-TYR226
CGLY78-ILE91
CASN208-TYR226
DGLY78-ILE91
DASN208-TYR226

site_idSWS_FT_FI5
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN128
BASN128
CASN128
DASN128

site_idSWS_FT_FI6
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21733844
ChainResidueDetails
AASN133
BASN133
CASN133
DASN133

218853

PDB entries from 2024-04-24

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