6F5Q

Crystal Structure of KDM4D with GF026 ligand

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	CYS238
A	HIS244
A	CYS310
A	CYS312

---

site_id	AC2
Number of Residues	2
Details	binding site for residue CL A 402

Chain	Residue
A	ASN128
A	LYS186

---

site_id	AC3
Number of Residues	6
Details	binding site for residue EDO A 403

Chain	Residue
A	ASN128
A	HOH710
A	HOH791
A	ARG123
A	LYS124
A	LYS127

---

site_id	AC4
Number of Residues	7
Details	binding site for residue EDO A 404

Chain	Residue
A	LYS150
A	GLN151
A	TRP152
A	ASN153
A	HIS156
A	HOH675
A	HOH717

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 405

Chain	Residue
A	PRO251
A	THR252
A	LYS255
A	ARG263
A	EDO407

---

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO A 406

Chain	Residue
A	LYS109
A	GLN111
A	ASN132
A	TRP185
A	LYS186
A	HOH668

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO A 407

Chain	Residue
A	GLU122
A	ARG123
A	TRP126
A	EDO405
A	HOH532
A	HOH599
A	HOH605

---

site_id	AC8
Number of Residues	6
Details	binding site for residue EDO A 408

Chain	Residue
A	PHE118
A	GLU122
A	ARG263
A	THR265
A	HOH572
A	HOH735

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO A 409

Chain	Residue
A	GLU27
A	TYR37
A	HOH637
A	HOH640
A	HOH831

---

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO A 410

Chain	Residue
A	LYS25
A	GLU26
A	ASN106
A	HOH505
A	HOH715

---

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO A 411

Chain	Residue
A	TYR181
A	ILE293
A	ASN294
A	HOH520
A	HOH552

---

site_id	AD3
Number of Residues	7
Details	binding site for residue SO4 A 412

Chain	Residue
A	ARG60
A	THR62
A	ASN65
A	HOH513
A	HOH575
A	HOH771
A	HOH790

---

site_id	AD4
Number of Residues	6
Details	binding site for residue SO4 A 413

Chain	Residue
A	ARG102
A	HIS103
A	ASN106
A	HOH503
A	HOH536
A	HOH559

---

site_id	AD5
Number of Residues	6
Details	binding site for residue NI A 414

Chain	Residue
A	HIS192
A	GLU194
A	HIS280
A	CTK415
A	HOH552
A	HOH638

---

site_id	AD6
Number of Residues	15
Details	binding site for residue CTK A 415

Chain	Residue
A	HIS90
A	TYR136
A	THR188
A	PHE189
A	ALA190
A	HIS192
A	ASN202
A	LYS210
A	HIS280
A	NI414
A	HOH552
A	HOH638
A	HOH708
A	HOH746
A	HOH787

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	166
Details	Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"B2RXH2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PDB","id":"5F5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"PubMed","id":"23102699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---