6F3P

Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa in complex with 3'-deoxyadenosine and K+ cation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004013	molecular_function	adenosylhomocysteinase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006730	biological_process	one-carbon metabolic process
A	0016787	molecular_function	hydrolase activity
A	0033353	biological_process	S-adenosylmethionine cycle
A	0071269	biological_process	L-homocysteine biosynthetic process
C	0004013	molecular_function	adenosylhomocysteinase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006730	biological_process	one-carbon metabolic process
C	0016787	molecular_function	hydrolase activity
C	0033353	biological_process	S-adenosylmethionine cycle
C	0071269	biological_process	L-homocysteine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	32
Details	binding site for residue NAD A 501

Chain	Residue
A	THR166
A	VAL252
A	ASP253
A	CYS256
A	THR297
A	THR298
A	GLY299
A	ASN300
A	VAL303
A	ILE321
A	GLY322
A	THR167
A	HIS323
A	ASN375
A	HIS382
A	3AD502
A	CL504
A	HOH652
A	HOH731
A	HOH855
C	LYS463
C	TYR467
A	ASN199
C	HOH998
C	HOH1026
C	HOH1144
A	ILE227
A	GLY228
A	GLY230
A	ASP231
A	VAL232
A	GLU251

---

site_id	AC2
Number of Residues	14
Details	binding site for residue 3AD A 502

Chain	Residue
A	HIS61
A	THR63
A	GLN65
A	THR66
A	ASP139
A	GLU164
A	LYS194
A	ASP198
A	HIS323
A	THR380
A	HIS382
A	MET387
A	NAD501
A	CL504

---

site_id	AC3
Number of Residues	6
Details	binding site for residue K A 503

Chain	Residue
A	GLN65
A	THR380
A	HIS382
A	HOH826
A	HOH863
C	HOH827

---

site_id	AC4
Number of Residues	7
Details	binding site for residue CL A 504

Chain	Residue
A	THR165
A	THR166
A	ASN189
A	LYS194
A	ASN199
A	NAD501
A	3AD502

---

site_id	AC5
Number of Residues	7
Details	binding site for residue PO4 A 505

Chain	Residue
A	ARG25
A	ILE29
A	GLU32
A	HOH641
A	HOH804
A	HOH817
C	HIS360

---

site_id	AC6
Number of Residues	32
Details	binding site for residue NAD C 501

Chain	Residue
A	LYS463
A	TYR467
A	HOH946
A	HOH969
C	THR166
C	THR167
C	ASN199
C	ILE227
C	GLY228
C	GLY230
C	ASP231
C	VAL232
C	GLU251
C	VAL252
C	ASP253
C	CYS256
C	THR297
C	THR298
C	GLY299
C	ASN300
C	VAL303
C	ILE321
C	GLY322
C	HIS323
C	ASN375
C	HIS382
C	3AD502
C	CL504
C	HOH633
C	HOH733
C	HOH744
C	HOH876

---

site_id	AC7
Number of Residues	16
Details	binding site for residue 3AD C 502

Chain	Residue
C	THR63
C	GLN65
C	THR66
C	ASP139
C	GLU164
C	LYS194
C	ASP198
C	HIS323
C	LEU373
C	THR380
C	HIS382
C	MET387
C	PHE391
C	NAD501
C	CL504
C	HIS61

---

site_id	AC8
Number of Residues	6
Details	binding site for residue K C 503

Chain	Residue
A	HOH780
C	GLN65
C	THR380
C	HIS382
C	HOH842
C	HOH890

---

site_id	AC9
Number of Residues	7
Details	binding site for residue CL C 504

Chain	Residue
C	THR165
C	THR166
C	ASN189
C	LYS194
C	ASN199
C	NAD501
C	3AD502

---

site_id	AD1
Number of Residues	8
Details	binding site for residue PO4 C 505

Chain	Residue
A	HIS360
C	ARG25
C	ILE29
C	GLU32
C	HOH640
C	HOH735
C	HOH914
C	HOH993

---

Functional Information from PROSITE/UniProt

site_id	PS00738
Number of Residues	15
Details	ADOHCYASE_1 S-adenosyl-L-homocysteine hydrolase signature 1. SCNiFSTQDqAAAAI

Chain	Residue	Details
A	SER84-ILE98

---

site_id	PS00739
Number of Residues	17
Details	ADOHCYASE_2 S-adenosyl-L-homocysteine hydrolase signature 2. GKqalViGYGdVGKGs.S

Chain	Residue	Details
A	GLY221-SER237

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00563","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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