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6F08

14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001525biological_processangiogenesis
A0003016biological_processrespiratory system process
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005925cellular_componentfocal adhesion
A0006468biological_processprotein phosphorylation
A0006605biological_processprotein targeting
A0007165biological_processsignal transduction
A0008039biological_processsynaptic target recognition
A0019901molecular_functionprotein kinase binding
A0019904molecular_functionprotein domain specific binding
A0030324biological_processlung development
A0031625molecular_functionubiquitin protein ligase binding
A0031647biological_processregulation of protein stability
A0031982cellular_componentvesicle
A0035148biological_processtube formation
A0042149biological_processcellular response to glucose starvation
A0042470cellular_componentmelanosome
A0042802molecular_functionidentical protein binding
A0043066biological_processnegative regulation of apoptotic process
A0043067biological_processregulation of programmed cell death
A0044325molecular_functiontransmembrane transporter binding
A0045296molecular_functioncadherin binding
A0045824biological_processnegative regulation of innate immune response
A0050815molecular_functionphosphoserine residue binding
A0051683biological_processestablishment of Golgi localization
A0070062cellular_componentextracellular exosome
A0070371biological_processERK1 and ERK2 cascade
A0070372biological_processregulation of ERK1 and ERK2 cascade
A0072562cellular_componentblood microparticle
A0090128biological_processregulation of synapse maturation
A0090168biological_processGolgi reassembly
A0098686cellular_componenthippocampal mossy fiber to CA3 synapse
A0098978cellular_componentglutamatergic synapse
A0140297molecular_functionDNA-binding transcription factor binding
A0140311molecular_functionprotein sequestering activity
A1900181biological_processnegative regulation of protein localization to nucleus
A1904262biological_processnegative regulation of TORC1 signaling
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001525biological_processangiogenesis
B0003016biological_processrespiratory system process
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005925cellular_componentfocal adhesion
B0006468biological_processprotein phosphorylation
B0006605biological_processprotein targeting
B0007165biological_processsignal transduction
B0008039biological_processsynaptic target recognition
B0019901molecular_functionprotein kinase binding
B0019904molecular_functionprotein domain specific binding
B0030324biological_processlung development
B0031625molecular_functionubiquitin protein ligase binding
B0031647biological_processregulation of protein stability
B0031982cellular_componentvesicle
B0035148biological_processtube formation
B0042149biological_processcellular response to glucose starvation
B0042470cellular_componentmelanosome
B0042802molecular_functionidentical protein binding
B0043066biological_processnegative regulation of apoptotic process
B0043067biological_processregulation of programmed cell death
B0044325molecular_functiontransmembrane transporter binding
B0045296molecular_functioncadherin binding
B0045824biological_processnegative regulation of innate immune response
B0050815molecular_functionphosphoserine residue binding
B0051683biological_processestablishment of Golgi localization
B0070062cellular_componentextracellular exosome
B0070371biological_processERK1 and ERK2 cascade
B0070372biological_processregulation of ERK1 and ERK2 cascade
B0072562cellular_componentblood microparticle
B0090128biological_processregulation of synapse maturation
B0090168biological_processGolgi reassembly
B0098686cellular_componenthippocampal mossy fiber to CA3 synapse
B0098978cellular_componentglutamatergic synapse
B0140297molecular_functionDNA-binding transcription factor binding
B0140311molecular_functionprotein sequestering activity
B1900181biological_processnegative regulation of protein localization to nucleus
B1904262biological_processnegative regulation of TORC1 signaling
I0000122biological_processnegative regulation of transcription by RNA polymerase II
I0001525biological_processangiogenesis
I0003016biological_processrespiratory system process
I0003723molecular_functionRNA binding
I0005515molecular_functionprotein binding
I0005615cellular_componentextracellular space
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005925cellular_componentfocal adhesion
I0006468biological_processprotein phosphorylation
I0006605biological_processprotein targeting
I0007165biological_processsignal transduction
I0008039biological_processsynaptic target recognition
I0019901molecular_functionprotein kinase binding
I0019904molecular_functionprotein domain specific binding
I0030324biological_processlung development
I0031625molecular_functionubiquitin protein ligase binding
I0031647biological_processregulation of protein stability
I0031982cellular_componentvesicle
I0035148biological_processtube formation
I0042149biological_processcellular response to glucose starvation
I0042470cellular_componentmelanosome
I0042802molecular_functionidentical protein binding
I0043066biological_processnegative regulation of apoptotic process
I0043067biological_processregulation of programmed cell death
I0044325molecular_functiontransmembrane transporter binding
I0045296molecular_functioncadherin binding
I0045824biological_processnegative regulation of innate immune response
I0050815molecular_functionphosphoserine residue binding
I0051683biological_processestablishment of Golgi localization
I0070062cellular_componentextracellular exosome
I0070371biological_processERK1 and ERK2 cascade
I0070372biological_processregulation of ERK1 and ERK2 cascade
I0072562cellular_componentblood microparticle
I0090128biological_processregulation of synapse maturation
I0090168biological_processGolgi reassembly
I0098686cellular_componenthippocampal mossy fiber to CA3 synapse
I0098978cellular_componentglutamatergic synapse
I0140297molecular_functionDNA-binding transcription factor binding
I0140311molecular_functionprotein sequestering activity
I1900181biological_processnegative regulation of protein localization to nucleus
I1904262biological_processnegative regulation of TORC1 signaling
J0000122biological_processnegative regulation of transcription by RNA polymerase II
J0001525biological_processangiogenesis
J0003016biological_processrespiratory system process
J0003723molecular_functionRNA binding
J0005515molecular_functionprotein binding
J0005615cellular_componentextracellular space
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0005925cellular_componentfocal adhesion
J0006468biological_processprotein phosphorylation
J0006605biological_processprotein targeting
J0007165biological_processsignal transduction
J0008039biological_processsynaptic target recognition
J0019901molecular_functionprotein kinase binding
J0019904molecular_functionprotein domain specific binding
J0030324biological_processlung development
J0031625molecular_functionubiquitin protein ligase binding
J0031647biological_processregulation of protein stability
J0031982cellular_componentvesicle
J0035148biological_processtube formation
J0042149biological_processcellular response to glucose starvation
J0042470cellular_componentmelanosome
J0042802molecular_functionidentical protein binding
J0043066biological_processnegative regulation of apoptotic process
J0043067biological_processregulation of programmed cell death
J0044325molecular_functiontransmembrane transporter binding
J0045296molecular_functioncadherin binding
J0045824biological_processnegative regulation of innate immune response
J0050815molecular_functionphosphoserine residue binding
J0051683biological_processestablishment of Golgi localization
J0070062cellular_componentextracellular exosome
J0070371biological_processERK1 and ERK2 cascade
J0070372biological_processregulation of ERK1 and ERK2 cascade
J0072562cellular_componentblood microparticle
J0090128biological_processregulation of synapse maturation
J0090168biological_processGolgi reassembly
J0098686cellular_componenthippocampal mossy fiber to CA3 synapse
J0098978cellular_componentglutamatergic synapse
J0140297molecular_functionDNA-binding transcription factor binding
J0140311molecular_functionprotein sequestering activity
J1900181biological_processnegative regulation of protein localization to nucleus
J1904262biological_processnegative regulation of TORC1 signaling
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue 1PE A 301
ChainResidue
AMET1
ALYS9
AASP21
ACYS25
BMET78
BTYR82

Functional Information from PROSITE/UniProt
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
AARG41-VAL51

site_idPS00797
Number of Residues20
Details1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS
ChainResidueDetails
ATYR211-SER230

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: Phosphoserine; by RPS6KA3 => ECO:0000269|PubMed:22827337
ChainResidueDetails
DSEP7
KSEP7
NSEP7
QSEP7
IARG56
IARG127
JARG56
JARG127

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|Ref.8, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
AMET1
BMET1
IMET1
JMET1

site_idSWS_FT_FI3
Number of Residues8
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS3
ALYS68
BLYS3
BLYS68
ILYS3
ILYS68
JLYS3
JLYS68

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA and PKB/AKT1 => ECO:0000269|PubMed:11956222, ECO:0000269|PubMed:12865427, ECO:0000269|PubMed:15883165, ECO:0000269|PubMed:16376338
ChainResidueDetails
ASER58
BSER58
ISER58
JSER58

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine; by MAPK8 => ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15696159
ChainResidueDetails
ASER184
BSER184
ISER184
JSER184

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231
ChainResidueDetails
BSER207
ISER207
JSER207
ASER207

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P63102
ChainResidueDetails
ASER210
BSER210
ISER210
JSER210

218500

PDB entries from 2024-04-17

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