6F06
CATHEPSIN L IN COMPLEX WITH (3S,14E)-8-(azetidin-3-yl)-19-chloro-N-(1-cyanocyclopropyl)-5-oxo-12,17-dioxa-4-azatricyclo[16.2.2.06,11]docosa-1(21),6,8,10,14,18(22),19-heptaene-3-carboxamide
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006508 | biological_process | proteolysis |
A | 0008234 | molecular_function | cysteine-type peptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | binding site for residue C7T A 301 |
Chain | Residue |
A | GLY23 |
A | MET70 |
A | ALA135 |
A | MET161 |
A | ASP162 |
A | ALA214 |
A | ZN302 |
A | CL308 |
A | HOH444 |
A | SER24 |
A | CYS25 |
A | TRP26 |
A | GLU63 |
A | ASN66 |
A | GLY67 |
A | GLY68 |
A | LEU69 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue ZN A 302 |
Chain | Residue |
A | CYS25 |
A | HIS163 |
A | C7T301 |
A | CL308 |
A | HOH402 |
site_id | AC3 |
Number of Residues | 2 |
Details | binding site for residue ZN A 303 |
Chain | Residue |
A | ASP137 |
A | HIS140 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue ZN A 304 |
Chain | Residue |
A | LEU48 |
A | GLU50 |
A | GLU86 |
A | HOH434 |
A | HOH447 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue ZN A 305 |
Chain | Residue |
A | GLU92 |
A | GLU96 |
A | HOH403 |
B | GLU191 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue ZN A 306 |
Chain | Residue |
A | ASP71 |
A | ASP114 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue ZN A 307 |
Chain | Residue |
A | HIS140 |
A | GLU153 |
A | ASP155 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue CL A 308 |
Chain | Residue |
A | GLN19 |
A | HIS163 |
A | C7T301 |
A | ZN302 |
site_id | AC9 |
Number of Residues | 18 |
Details | binding site for residue C7T B 301 |
Chain | Residue |
B | GLY23 |
B | SER24 |
B | CYS25 |
B | TRP26 |
B | GLY61 |
B | GLU63 |
B | ASN66 |
B | GLY67 |
B | GLY68 |
B | LEU69 |
B | MET70 |
B | ALA135 |
B | ASP162 |
B | ALA214 |
B | ZN302 |
B | CL310 |
B | HOH408 |
B | HOH442 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue ZN B 302 |
Chain | Residue |
B | CYS25 |
B | HIS163 |
B | C7T301 |
B | CL310 |
B | HOH408 |
site_id | AD2 |
Number of Residues | 3 |
Details | binding site for residue ZN B 303 |
Chain | Residue |
B | ASP137 |
B | HIS140 |
B | HOH441 |
site_id | AD3 |
Number of Residues | 3 |
Details | binding site for residue ZN B 304 |
Chain | Residue |
A | GLU87 |
B | ASP6 |
B | GLU9 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue ZN B 305 |
Chain | Residue |
B | LEU48 |
B | GLU50 |
B | GLU86 |
B | HOH419 |
B | HOH434 |
site_id | AD5 |
Number of Residues | 2 |
Details | binding site for residue ZN B 306 |
Chain | Residue |
B | ASP71 |
B | ASP114 |
site_id | AD6 |
Number of Residues | 4 |
Details | binding site for residue ZN B 307 |
Chain | Residue |
B | HIS140 |
B | GLU153 |
B | ASP155 |
B | HOH439 |
site_id | AD7 |
Number of Residues | 4 |
Details | binding site for residue ZN B 308 |
Chain | Residue |
A | GLU191 |
B | GLU92 |
B | GLU96 |
B | ZN309 |
site_id | AD8 |
Number of Residues | 5 |
Details | binding site for residue ZN B 309 |
Chain | Residue |
A | GLU191 |
B | LYS10 |
B | GLU92 |
B | GLU96 |
B | ZN308 |
site_id | AD9 |
Number of Residues | 5 |
Details | binding site for residue CL B 310 |
Chain | Residue |
B | GLN19 |
B | HIS163 |
B | TRP189 |
B | C7T301 |
B | ZN302 |
Functional Information from PROSITE/UniProt
site_id | PS00139 |
Number of Residues | 12 |
Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSA |
Chain | Residue | Details |
A | GLN19-ALA30 | |
site_id | PS00639 |
Number of Residues | 11 |
Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. MDHGVLVVGYG |
Chain | Residue | Details |
A | MET161-GLY171 | |
site_id | PS00640 |
Number of Residues | 20 |
Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWgeeWGmgGYVkM |
Chain | Residue | Details |
A | TYR182-MET201 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | CYS25 | |
B | CYS25 | |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: |
Chain | Residue | Details |
A | HIS163 | |
A | ASN187 | |
B | HIS163 | |
B | ASN187 | |
Chain | Residue | Details |
A | ASN108 | |
B | ASN108 | |