6F06
CATHEPSIN L IN COMPLEX WITH (3S,14E)-8-(azetidin-3-yl)-19-chloro-N-(1-cyanocyclopropyl)-5-oxo-12,17-dioxa-4-azatricyclo[16.2.2.06,11]docosa-1(21),6,8,10,14,18(22),19-heptaene-3-carboxamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue C7T A 301 |
| Chain | Residue |
| A | GLY23 |
| A | MET70 |
| A | ALA135 |
| A | MET161 |
| A | ASP162 |
| A | ALA214 |
| A | ZN302 |
| A | CL308 |
| A | HOH444 |
| A | SER24 |
| A | CYS25 |
| A | TRP26 |
| A | GLU63 |
| A | ASN66 |
| A | GLY67 |
| A | GLY68 |
| A | LEU69 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 302 |
| Chain | Residue |
| A | CYS25 |
| A | HIS163 |
| A | C7T301 |
| A | CL308 |
| A | HOH402 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue ZN A 303 |
| Chain | Residue |
| A | ASP137 |
| A | HIS140 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 304 |
| Chain | Residue |
| A | LEU48 |
| A | GLU50 |
| A | GLU86 |
| A | HOH434 |
| A | HOH447 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 305 |
| Chain | Residue |
| A | GLU92 |
| A | GLU96 |
| A | HOH403 |
| B | GLU191 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue ZN A 306 |
| Chain | Residue |
| A | ASP71 |
| A | ASP114 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue ZN A 307 |
| Chain | Residue |
| A | HIS140 |
| A | GLU153 |
| A | ASP155 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 308 |
| Chain | Residue |
| A | GLN19 |
| A | HIS163 |
| A | C7T301 |
| A | ZN302 |
| site_id | AC9 |
| Number of Residues | 18 |
| Details | binding site for residue C7T B 301 |
| Chain | Residue |
| B | GLY23 |
| B | SER24 |
| B | CYS25 |
| B | TRP26 |
| B | GLY61 |
| B | GLU63 |
| B | ASN66 |
| B | GLY67 |
| B | GLY68 |
| B | LEU69 |
| B | MET70 |
| B | ALA135 |
| B | ASP162 |
| B | ALA214 |
| B | ZN302 |
| B | CL310 |
| B | HOH408 |
| B | HOH442 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 302 |
| Chain | Residue |
| B | CYS25 |
| B | HIS163 |
| B | C7T301 |
| B | CL310 |
| B | HOH408 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue ZN B 303 |
| Chain | Residue |
| B | ASP137 |
| B | HIS140 |
| B | HOH441 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue ZN B 304 |
| Chain | Residue |
| A | GLU87 |
| B | ASP6 |
| B | GLU9 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 305 |
| Chain | Residue |
| B | LEU48 |
| B | GLU50 |
| B | GLU86 |
| B | HOH419 |
| B | HOH434 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue ZN B 306 |
| Chain | Residue |
| B | ASP71 |
| B | ASP114 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 307 |
| Chain | Residue |
| B | HIS140 |
| B | GLU153 |
| B | ASP155 |
| B | HOH439 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 308 |
| Chain | Residue |
| A | GLU191 |
| B | GLU92 |
| B | GLU96 |
| B | ZN309 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 309 |
| Chain | Residue |
| A | GLU191 |
| B | LYS10 |
| B | GLU92 |
| B | GLU96 |
| B | ZN308 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue CL B 310 |
| Chain | Residue |
| B | GLN19 |
| B | HIS163 |
| B | TRP189 |
| B | C7T301 |
| B | ZN302 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSA |
| Chain | Residue | Details |
| A | GLN19-ALA30 | |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. MDHGVLVVGYG |
| Chain | Residue | Details |
| A | MET161-GLY171 | |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWgeeWGmgGYVkM |
| Chain | Residue | Details |
| A | TYR182-MET201 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Propeptide: {"featureId":"PRO_0000026246"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"9468501","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HFV","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
