6EZE
The open conformation of E.coli Elongation Factor Tu in complex with GDPNP.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003746 | molecular_function | translation elongation factor activity |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006412 | biological_process | translation |
| A | 0006414 | biological_process | translational elongation |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0032045 | cellular_component | guanyl-nucleotide exchange factor complex |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0097216 | molecular_function | guanosine tetraphosphate binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003746 | molecular_function | translation elongation factor activity |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006412 | biological_process | translation |
| B | 0006414 | biological_process | translational elongation |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0032045 | cellular_component | guanyl-nucleotide exchange factor complex |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0097216 | molecular_function | guanosine tetraphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue GNP A 401 |
| Chain | Residue |
| A | VAL20 |
| A | ASP138 |
| A | MET139 |
| A | SER173 |
| A | ALA174 |
| A | LEU175 |
| A | MG402 |
| A | HOH511 |
| A | HOH515 |
| A | HOH517 |
| A | HOH542 |
| A | ASP21 |
| A | HOH603 |
| A | HIS22 |
| A | GLY23 |
| A | LYS24 |
| A | THR25 |
| A | THR26 |
| A | ASN135 |
| A | LYS136 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | THR25 |
| A | GNP401 |
| A | HOH511 |
| A | HOH515 |
| A | HOH517 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | ARG288 |
| A | ARG377 |
| A | HOH522 |
| A | HOH577 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | ASP165 |
| A | ASP166 |
| A | THR167 |
| A | HOH557 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | GLU183 |
| A | TRP184 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 406 |
| Chain | Residue |
| A | LEU120 |
| A | GLU307 |
| A | ASN355 |
| A | HOH520 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 407 |
| Chain | Residue |
| A | MET260 |
| A | PHE261 |
| A | ARG262 |
| A | LYS263 |
| B | ARG288 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 408 |
| Chain | Residue |
| A | LEU211 |
| A | ARG233 |
| A | ARG333 |
| A | ASP369 |
| A | LEU372 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 409 |
| Chain | Residue |
| A | PRO111 |
| A | MET112 |
| A | PRO113 |
| A | ARG116 |
| A | HOH531 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue PEG A 410 |
| Chain | Residue |
| A | HIS84 |
| A | ALA85 |
| A | GLN114 |
| site_id | AD2 |
| Number of Residues | 21 |
| Details | binding site for residue GNP B 401 |
| Chain | Residue |
| B | VAL20 |
| B | ASP21 |
| B | HIS22 |
| B | GLY23 |
| B | LYS24 |
| B | THR25 |
| B | THR26 |
| B | PHE46 |
| B | ASN135 |
| B | LYS136 |
| B | ASP138 |
| B | MET139 |
| B | SER173 |
| B | ALA174 |
| B | LEU175 |
| B | MG402 |
| B | HOH510 |
| B | HOH528 |
| B | HOH555 |
| B | HOH574 |
| B | HOH585 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 402 |
| Chain | Residue |
| B | THR25 |
| B | GNP401 |
| B | HOH510 |
| B | HOH528 |
| B | HOH555 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| B | ARG318 |
| B | TYR326 |
| B | HOH503 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 404 |
| Chain | Residue |
| B | TYR331 |
| B | ARG333 |
| B | ARG373 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue GOL B 405 |
| Chain | Residue |
| B | ARG327 |
| B | THR338 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue GOL B 406 |
| Chain | Residue |
| A | ARG283 |
| B | ARG262 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 407 |
| Chain | Residue |
| A | ARG288 |
| B | MET260 |
| B | PHE261 |
| B | ARG262 |
| B | LYS263 |
| B | HOH543 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 408 |
| Chain | Residue |
| B | PRO111 |
| B | MET112 |
| B | PRO113 |
| B | ARG116 |
Functional Information from PROSITE/UniProt
| site_id | PS00301 |
| Number of Residues | 16 |
| Details | G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DNapeEKaRGITIntS |
| Chain | Residue | Details |
| A | ASP50-SER65 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 388 |
| Details | Domain: {"description":"tr-type G"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Region: {"description":"G1","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Region: {"description":"G2","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Region: {"description":"G3","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Region: {"description":"G4","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Region: {"description":"G5","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 28 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00118","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"21151122","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"2022614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"389663","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6997043","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7021545","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"21151122","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19150849","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24141193","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"8416965","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
