6EZB

Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain Q305K mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008033	biological_process	tRNA processing
A	0017150	molecular_function	tRNA dihydrouridine synthase activity
A	0050660	molecular_function	flavin adenine dinucleotide binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue FMN A 401

Chain	Residue
A	PRO18
A	GLY215
A	GLY216
A	SER217
A	ALA242
A	ARG243
A	GOL405
A	SO4406
A	HOH506
A	HOH519
A	MET19
A	VAL20
A	GLU43
A	GLN87
A	ASN113
A	LYS155
A	HIS183
A	ASN214

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 402

Chain	Residue
A	ARG21
A	HIS277
A	THR279
A	ASN280

---

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 A 403

Chain	Residue
A	SER91
A	ARG95
A	GLY315
A	LEU316
A	GLY317
A	ALA318

---

site_id	AC4
Number of Residues	2
Details	binding site for residue SO4 A 404

Chain	Residue
A	ASN82
A	ARG83

---

site_id	AC5
Number of Residues	7
Details	binding site for residue GOL A 405

Chain	Residue
A	VAL20
A	GLU43
A	ASN113
A	CYS116
A	PRO117
A	FMN401
A	SO4406

---

site_id	AC6
Number of Residues	6
Details	binding site for residue SO4 A 406

Chain	Residue
A	GLY115
A	LYS155
A	ARG157
A	HIS183
A	FMN401
A	GOL405

---

Functional Information from PROSITE/UniProt

site_id	PS01136
Number of Residues	19
Details	UPF0034 Uncharacterized protein family UPF0034 signature. IDVNmGCPkqy.Stkggm.GA

Chain	Residue	Details
A	ILE110-ALA128

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"38680565","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26143927","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26429968","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WFS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XP7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26429968","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WFS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---