6ET2

Crystal structure of PqsBC (C129A) mutant from Pseudomonas aeruginosa (crystal form 3)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0005737	cellular_component	cytoplasm
A	0006633	biological_process	fatty acid biosynthetic process
A	0016746	molecular_function	acyltransferase activity
A	0044550	biological_process	secondary metabolite biosynthetic process
B	0005737	cellular_component	cytoplasm
B	0016746	molecular_function	acyltransferase activity
B	0044550	biological_process	secondary metabolite biosynthetic process
C	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
C	0005737	cellular_component	cytoplasm
C	0006633	biological_process	fatty acid biosynthetic process
C	0016746	molecular_function	acyltransferase activity
C	0044550	biological_process	secondary metabolite biosynthetic process
D	0005737	cellular_component	cytoplasm
D	0016746	molecular_function	acyltransferase activity
D	0044550	biological_process	secondary metabolite biosynthetic process
E	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
E	0005737	cellular_component	cytoplasm
E	0006633	biological_process	fatty acid biosynthetic process
E	0016746	molecular_function	acyltransferase activity
E	0044550	biological_process	secondary metabolite biosynthetic process
F	0005737	cellular_component	cytoplasm
F	0016746	molecular_function	acyltransferase activity
F	0044550	biological_process	secondary metabolite biosynthetic process
G	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
G	0005737	cellular_component	cytoplasm
G	0006633	biological_process	fatty acid biosynthetic process
G	0016746	molecular_function	acyltransferase activity
G	0044550	biological_process	secondary metabolite biosynthetic process
H	0005737	cellular_component	cytoplasm
H	0016746	molecular_function	acyltransferase activity
H	0044550	biological_process	secondary metabolite biosynthetic process
I	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
I	0005737	cellular_component	cytoplasm
I	0006633	biological_process	fatty acid biosynthetic process
I	0016746	molecular_function	acyltransferase activity
I	0044550	biological_process	secondary metabolite biosynthetic process
J	0005737	cellular_component	cytoplasm
J	0016746	molecular_function	acyltransferase activity
J	0044550	biological_process	secondary metabolite biosynthetic process
K	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
K	0005737	cellular_component	cytoplasm
K	0006633	biological_process	fatty acid biosynthetic process
K	0016746	molecular_function	acyltransferase activity
K	0044550	biological_process	secondary metabolite biosynthetic process
L	0005737	cellular_component	cytoplasm
L	0016746	molecular_function	acyltransferase activity
L	0044550	biological_process	secondary metabolite biosynthetic process
M	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
M	0005737	cellular_component	cytoplasm
M	0006633	biological_process	fatty acid biosynthetic process
M	0016746	molecular_function	acyltransferase activity
M	0044550	biological_process	secondary metabolite biosynthetic process
N	0005737	cellular_component	cytoplasm
N	0016746	molecular_function	acyltransferase activity
N	0044550	biological_process	secondary metabolite biosynthetic process
O	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
O	0005737	cellular_component	cytoplasm
O	0006633	biological_process	fatty acid biosynthetic process
O	0016746	molecular_function	acyltransferase activity
O	0044550	biological_process	secondary metabolite biosynthetic process
P	0005737	cellular_component	cytoplasm
P	0016746	molecular_function	acyltransferase activity
P	0044550	biological_process	secondary metabolite biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue MPO A 900

Chain	Residue
A	SER85
A	GLU128
A	ALA129
A	GLY209
A	ILE301
A	THR331
A	HOH1022
B	ALA77

---

site_id	AC2
Number of Residues	8
Details	binding site for residue MPO C 900

Chain	Residue
C	GLU128
C	ALA129
C	GLY209
C	ILE301
C	ALA330
C	THR331
D	ALA77
C	SER85

---

site_id	AC3
Number of Residues	8
Details	binding site for residue MPO E 900

Chain	Residue
E	GLU128
E	ALA129
E	THR208
E	GLY209
E	ILE301
E	ALA330
E	THR331
F	ALA77

---

site_id	AC4
Number of Residues	7
Details	binding site for residue MPO G 900

Chain	Residue
G	SER85
G	ALA129
G	PHE173
G	ILE301
G	ALA330
G	THR331
H	ALA77

---

site_id	AC5
Number of Residues	10
Details	binding site for residue MPO I 900

Chain	Residue
I	SER85
I	GLU128
I	ALA129
I	THR208
I	GLY209
I	PHE227
I	ILE301
I	ALA330
I	THR331
J	ALA77

---

site_id	AC6
Number of Residues	8
Details	binding site for residue MPO K 900

Chain	Residue
K	SER85
K	GLU128
K	ALA129
K	ILE301
K	ALA330
K	THR331
K	HOH1004
L	ALA77

---

site_id	AC7
Number of Residues	8
Details	binding site for residue MPO M 900

Chain	Residue
M	GLU128
M	ALA129
M	PHE173
M	GLY209
M	ILE301
M	ALA330
M	THR331
N	ALA77

---

site_id	AC8
Number of Residues	8
Details	binding site for residue MPO O 900

Chain	Residue
O	SER85
O	ALA129
O	ILE159
O	LEU162
O	ILE301
O	ALA330
O	THR331
P	ALA77

---

Functional Information from PROSITE/UniProt

site_id	PS00430
Number of Residues	80
Details	TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. mghhhhhhaenlyfqghmhkvklaaitcelparsyenddpvfaavpdlseswwqfwgvnrrgyfdprngene...........................................FSLVVRAA

Chain	Residue	Details
A	MET-16-ALA63

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Acyl-thioester intermediate => ECO:0000305|PubMed:24239007, ECO:0000305|PubMed:26811339

Chain	Residue	Details
A	ALA129
C	ALA129
E	ALA129
G	ALA129
I	ALA129
K	ALA129
M	ALA129
O	ALA129

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:26811339

Chain	Residue	Details
A	HIS269
C	HIS269
E	HIS269
G	HIS269
I	HIS269
K	HIS269
M	HIS269
O	HIS269

---