6EQV

X-ray structure of the proprotein convertase furin bound with the competitive inhibitor Phac-Cit-Val-Arg-Amba

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 601

Chain	Residue
A	ASP174
A	ASP179
A	ASP181
A	HOH767
A	HOH773
A	HOH1118

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CA A 602

Chain	Residue
A	ASN208
A	VAL210
A	GLY212
A	ASP115
A	ASP162
A	VAL205

---

site_id	AC3
Number of Residues	6
Details	binding site for residue CA A 603

Chain	Residue
A	ASP258
A	ASP301
A	GLU331
A	HOH843
A	HOH890
A	HOH997

---

site_id	AC4
Number of Residues	4
Details	binding site for residue NA A 604

Chain	Residue
A	THR309
A	SER311
A	THR314
A	HOH808

---

site_id	AC5
Number of Residues	6
Details	binding site for residue NA A 605

Chain	Residue
A	SER279
A	GLY284
A	HOH713
A	HOH800
A	HOH1122
A	HOH1141

---

site_id	AC6
Number of Residues	4
Details	binding site for residue NA A 606

Chain	Residue
A	SER544
A	SER544
A	HOH774
A	HOH774

---

site_id	AC7
Number of Residues	6
Details	binding site for residue NA A 607

Chain	Residue
A	GLU546
A	GLU546
A	HOH1091
A	HOH1091
A	HOH1097
A	HOH1097

---

site_id	AC8
Number of Residues	3
Details	binding site for residue CL A 608

Chain	Residue
A	TYR313
A	LYS449
A	TYR571

---

site_id	AC9
Number of Residues	9
Details	binding site for residues HY1 D 1 and CIR D 2

Chain	Residue
A	GLU236
A	GLY255
A	GLU257
A	ASP264
A	GLY265
A	TYR308
A	HOH852
D	VAL3
D	HOH101

---

Functional Information from PROSITE/UniProt

site_id	PS00136
Number of Residues	12
Details	SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. VSILDDGIeknH

Chain	Residue	Details
A	VAL149-HIS160

---

site_id	PS00137
Number of Residues	11
Details	SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGTrCAGeVAA

Chain	Residue	Details
A	HIS194-ALA204

---

site_id	PS00138
Number of Residues	11
Details	SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSaSaPlAAG

Chain	Residue	Details
A	GLY366-GLY376

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240

Chain	Residue	Details
A	ASP153
A	HIS194
A	SER368

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD

Chain	Residue	Details
A	ASP115
A	ASP258
A	ASP301
A	GLU331
A	ASP162
A	ASP174
A	ASP179
A	ASP181
A	VAL205
A	ASN208
A	VAL210
A	GLY212

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	BINDING: BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD

Chain	Residue	Details
A	ASP154
A	ASP191
A	GLU236
A	SER253
A	ASP264
A	ALA292
A	ASP306
A	TYR308
A	SER368

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN387
A	ASN440
A	ASN553

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