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6EQ9

Crystal structure of JNK3 in complex with AMP-PCP

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004707molecular_functionMAP kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0004707molecular_functionMAP kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue MG A 501
ChainResidue
AGLN75
AASP207
AACP505
AHOH654
AHOH738

site_idAC2
Number of Residues6
Detailsbinding site for residue NA A 502
ChainResidue
AILE124
AHOH693
AVAL118
AASN119
AHIS120
AILE123

site_idAC3
Number of Residues5
Detailsbinding site for residue NA A 503
ChainResidue
AILE276
ATHR281
APRO302
AHOH717
AHOH722

site_idAC4
Number of Residues1
Detailsbinding site for residue BME A 504
ChainResidue
ACYS201

site_idAC5
Number of Residues24
Detailsbinding site for residue ACP A 505
ChainResidue
AILE70
AGLY71
AGLY73
AALA74
AGLN75
AGLY76
AALA91
ALYS93
AMET146
AGLU147
AMET149
AASN152
ALYS191
ASER193
AASN194
ALEU206
AASP207
AMG501
AHOH654
AHOH686
AHOH716
AHOH726
AHOH738
AHOH742

site_idAC6
Number of Residues12
Detailsbinding site for residue C15 A 506
ChainResidue
AGLY215
ATHR216
AILE235
ALEU236
AGLY237
AGLY239
AGLN291
AVAL294
AHOH681
BGLU160
BASP162
BARG165

site_idAC7
Number of Residues4
Detailsbinding site for residue PEG A 507
ChainResidue
AILE269
ATYR297
BASP150
BPEG503

site_idAC8
Number of Residues5
Detailsbinding site for residue CL B 501
ChainResidue
AHOH690
BGLU242
BASN243
BVAL350
BHOH620

site_idAC9
Number of Residues23
Detailsbinding site for residue ACP B 502
ChainResidue
BILE70
BSER72
BGLY73
BALA74
BVAL78
BALA91
BLYS93
BILE124
BMET146
BGLU147
BMET149
BASN152
BLYS191
BSER193
BASN194
BLEU206
BASP207
BHOH619
BHOH626
BHOH631
BHOH644
BHOH659
BHOH666

site_idAD1
Number of Residues1
Detailsbinding site for residue PEG B 503
ChainResidue
APEG507

site_idAD2
Number of Residues2
Detailsbinding site for residue PEG B 504
ChainResidue
BILE269
BTHR293

Functional Information from PROSITE/UniProt
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpsNIVV
ChainResidueDetails
AILE185-VAL197

site_idPS01351
Number of Residues103
DetailsMAPK MAP kinase signature. FqnqthakrayRElvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhermsyllyqmlcgikhlhsagiih..........RDlKpsnivvksdC
ChainResidueDetails
APHE99-CYS201

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AASP189
BASP189

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING:
ChainResidueDetails
AILE70
ALYS93
BILE70
BLYS93

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by MAP2K7 => ECO:0000269|PubMed:10715136
ChainResidueDetails
ATHR221
BTHR221

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by MAP2K4 => ECO:0000269|PubMed:10715136
ChainResidueDetails
ATYR223
BTYR223

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PDB entries from 2024-11-06

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