Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 701 |
| Chain | Residue |
| D | ARG31 |
| D | GLU136 |
| D | TRP145 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 702 |
| Chain | Residue |
| D | ASN485 |
| D | LYS491 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 703 |
| Chain | Residue |
| D | GLY461 |
| D | ASP462 |
| D | GLY463 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 705 |
| Chain | Residue |
| D | GLY83 |
| D | LYS300 |
| D | GLN302 |
| D | VAL82 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue EDO D 706 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue EDO D 707 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | binding site for residue BQZ D 708 |
| Chain | Residue |
| D | TRP110 |
| D | GLY111 |
| D | TRP317 |
| D | ARG320 |
| D | ASN333 |
| D | GLU335 |
| D | ASN484 |
| D | TYR487 |
| D | SER515 |
| D | ARG533 |
| D | TRP639 |
| D | GLU641 |
| D | HOH809 |
| D | HOH838 |
| D | HOH843 |
| D | HOH856 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue CA D 709 |
| Chain | Residue |
| D | ASP458 |
| D | ASP460 |
| D | ASP462 |
| D | PHE464 |
| D | ASN466 |
| D | ASN476 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue PEG D 710 |
| Chain | Residue |
| B | ASP283 |
| B | SER315 |
| D | LYS300 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue PEG D 711 |
| Chain | Residue |
| D | VAL322 |
| D | ASN339 |
| D | ALA342 |
| D | SER343 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue PEG D 712 |
| Chain | Residue |
| B | SER279 |
| B | PHE662 |
| D | GLY76 |
| D | ASN77 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue P4G D 713 |
| Chain | Residue |
| B | GLY76 |
| B | ASN77 |
| D | SER279 |
| D | PHE662 |
| D | HOH925 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue PG4 D 714 |
| Chain | Residue |
| C | ASP460 |
| C | ASP462 |
| D | SER492 |
| D | GLY496 |
| D | GLN500 |
| D | LYS503 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue CL D 715 |
| Chain | Residue |
| D | PRO264 |
| D | MET267 |
| D | TYR280 |
| site_id | AD6 |
| Number of Residues | 1 |
| Details | binding site for residue CL D 717 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue CL D 718 |
| Chain | Residue |
| D | GLY359 |
| D | GLY617 |
| D | PRO633 |
| D | ILE634 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue CL D 719 |
| Chain | Residue |
| D | THR254 |
| D | TYR255 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue CL D 720 |
| Chain | Residue |
| D | ARG96 |
| D | TYR280 |
| D | PRO282 |
| D | ASP283 |
| site_id | AE1 |
| Number of Residues | 1 |
| Details | binding site for residue CL D 721 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 701 |
| site_id | AE3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 702 |
| Chain | Residue |
| B | ASN485 |
| B | LYS491 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 703 |
| Chain | Residue |
| B | ASP32 |
| D | GLN656 |
| D | GLY657 |
| D | TYR659 |
| site_id | AE5 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 704 |
| site_id | AE6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 705 |
| Chain | Residue |
| B | ALA116 |
| B | ARG123 |
| B | GLU641 |
| B | ASP642 |
| B | ILE645 |
| B | ARG646 |
| B | GLU647 |
| site_id | AE7 |
| Number of Residues | 15 |
| Details | binding site for residue BQZ B 706 |
| Chain | Residue |
| B | TRP639 |
| B | GLU641 |
| B | HOH806 |
| B | HOH810 |
| B | HOH874 |
| B | TRP110 |
| B | GLY111 |
| B | TRP317 |
| B | ARG320 |
| B | ASN333 |
| B | GLU335 |
| B | ASN484 |
| B | TYR487 |
| B | SER515 |
| B | ARG533 |
| site_id | AE8 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 708 |
| Chain | Residue |
| B | ASP458 |
| B | ASP460 |
| B | ASP462 |
| B | PHE464 |
| B | ASN466 |
| B | ASN476 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 709 |
| Chain | Residue |
| B | SER107 |
| B | GLN108 |
| B | GLY109 |
| B | TRP110 |
| B | ASP114 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue PEG B 710 |
| Chain | Residue |
| B | ASN339 |
| B | ALA342 |
| B | SER343 |
| B | ARG346 |
| B | HOH821 |
| site_id | AF2 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 711 |
| Chain | Residue |
| B | GLY76 |
| B | HOH909 |
| D | LYS313 |
| site_id | AF3 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 712 |
| site_id | AF4 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 713 |
| site_id | AF5 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 715 |
| Chain | Residue |
| B | ARG382 |
| B | THR480 |
| B | ASP528 |
| site_id | AF6 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 716 |
| Chain | Residue |
| C | LYS244 |
| C | TYR250 |
| site_id | AF7 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 717 |
| site_id | AF8 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 718 |
| site_id | AF9 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 719 |
| Chain | Residue |
| B | TRP48 |
| B | ASN308 |
| site_id | AG1 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 720 |
| Chain | Residue |
| B | ARG96 |
| B | TYR280 |
| B | PRO282 |
| B | ASP283 |
| site_id | AG2 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 721 |
| Chain | Residue |
| B | TRP376 |
| B | GLY377 |
| site_id | AG3 |
| Number of Residues | 1 |
| Details | binding site for residue EDO C 701 |
| site_id | AG4 |
| Number of Residues | 1 |
| Details | binding site for residue EDO C 703 |
| site_id | AG5 |
| Number of Residues | 1 |
| Details | binding site for residue EDO C 704 |
| site_id | AG6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 705 |
| Chain | Residue |
| C | ARG31 |
| C | LYS143 |
| C | SER144 |
| C | TRP145 |
| site_id | AG7 |
| Number of Residues | 9 |
| Details | binding site for residue EDO C 706 |
| Chain | Residue |
| C | GLY201 |
| C | GLU202 |
| C | GLY203 |
| C | THR204 |
| C | LYS219 |
| C | ALA220 |
| C | PRO223 |
| C | TYR226 |
| C | HOH904 |
| site_id | AG8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 707 |
| Chain | Residue |
| C | GLY76 |
| C | MET78 |
| C | PRO79 |
| C | ARG281 |
| C | PG4723 |
| C | HOH952 |
| site_id | AG9 |
| Number of Residues | 8 |
| Details | binding site for residue EDO C 708 |
| Chain | Residue |
| C | TRP110 |
| C | GLY192 |
| C | TYR232 |
| C | PRO233 |
| C | TRP639 |
| C | BQZ713 |
| C | HOH854 |
| C | HOH863 |
| site_id | AH1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 709 |
| Chain | Residue |
| C | LEU412 |
| C | VAL413 |
| C | LYS414 |
| C | HOH815 |
| site_id | AH2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO C 710 |
| Chain | Residue |
| C | THR400 |
| C | ARG405 |
| C | PRO422 |
| C | TYR439 |
| C | TYR440 |
| C | LEU607 |
| C | HOH804 |
| site_id | AH3 |
| Number of Residues | 10 |
| Details | binding site for residue EDO C 711 |
| Chain | Residue |
| C | ALA357 |
| C | PHE358 |
| C | GLY359 |
| C | GLY617 |
| C | LEU619 |
| C | THR632 |
| C | PRO633 |
| C | ILE634 |
| C | HOH807 |
| C | HOH812 |
| site_id | AH4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 712 |
| Chain | Residue |
| C | GLU338 |
| C | ASN339 |
| C | P4G722 |
| site_id | AH5 |
| Number of Residues | 17 |
| Details | binding site for residue BQZ C 713 |
| Chain | Residue |
| C | TRP110 |
| C | GLY111 |
| C | TRP317 |
| C | ARG320 |
| C | ASN333 |
| C | GLU335 |
| C | ASN484 |
| C | TYR487 |
| C | SER515 |
| C | ARG533 |
| C | TRP639 |
| C | GLU641 |
| C | EDO708 |
| C | HOH810 |
| C | HOH854 |
| C | HOH863 |
| C | HOH878 |
| site_id | AH6 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 714 |
| Chain | Residue |
| C | ASP458 |
| C | ASP460 |
| C | ASP462 |
| C | PHE464 |
| C | ASN466 |
| C | ASN476 |
| site_id | AH7 |
| Number of Residues | 2 |
| Details | binding site for residue CA C 716 |
| Chain | Residue |
| C | PRO264 |
| C | MET267 |
| site_id | AH8 |
| Number of Residues | 4 |
| Details | binding site for residue CA C 717 |
| Chain | Residue |
| C | ALA182 |
| C | VAL183 |
| C | ASP185 |
| C | VAL188 |
| site_id | AH9 |
| Number of Residues | 2 |
| Details | binding site for residue PEG C 718 |
| Chain | Residue |
| A | GLU23 |
| C | ALA348 |
| site_id | AI1 |
| Number of Residues | 3 |
| Details | binding site for residue PEG C 719 |
| Chain | Residue |
| C | ASN485 |
| C | ALA488 |
| C | LYS491 |
| site_id | AI2 |
| Number of Residues | 6 |
| Details | binding site for residue PEG C 720 |
| Chain | Residue |
| C | GLU299 |
| C | LYS300 |
| C | SER315 |
| C | ASP319 |
| C | CL737 |
| C | HOH900 |
| site_id | AI3 |
| Number of Residues | 7 |
| Details | binding site for residue PEG C 721 |
| Chain | Residue |
| C | SER44 |
| C | GLU45 |
| C | PRO46 |
| C | ASP47 |
| C | TYR85 |
| C | GLN302 |
| C | CL736 |
| site_id | AI4 |
| Number of Residues | 6 |
| Details | binding site for residue P4G C 722 |
| Chain | Residue |
| C | VAL322 |
| C | ASN339 |
| C | SER343 |
| C | ARG346 |
| C | EDO712 |
| C | HOH867 |
| site_id | AI5 |
| Number of Residues | 7 |
| Details | binding site for residue PG4 C 723 |
| Chain | Residue |
| C | ASN27 |
| C | GLY76 |
| C | PRO79 |
| C | SER279 |
| C | GLN630 |
| C | PHE662 |
| C | EDO707 |
| site_id | AI6 |
| Number of Residues | 5 |
| Details | binding site for residue CL C 724 |
| Chain | Residue |
| C | VAL84 |
| C | GLY86 |
| C | TRP650 |
| C | VAL651 |
| C | GLN656 |
| site_id | AI7 |
| Number of Residues | 1 |
| Details | binding site for residue CL C 725 |
| site_id | AI8 |
| Number of Residues | 1 |
| Details | binding site for residue CL C 726 |
| site_id | AI9 |
| Number of Residues | 2 |
| Details | binding site for residue CL C 727 |
| Chain | Residue |
| C | TYR255 |
| C | CL732 |
| site_id | AJ1 |
| Number of Residues | 2 |
| Details | binding site for residue CL C 728 |
| Chain | Residue |
| C | GLU23 |
| C | PHE358 |
| site_id | AJ2 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 729 |
| Chain | Residue |
| C | LYS623 |
| C | PHE625 |
| C | SER626 |
| site_id | AJ3 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 730 |
| Chain | Residue |
| C | GLU338 |
| C | VAL341 |
| C | ALA342 |
| C | HOH815 |
| site_id | AJ4 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 731 |
| Chain | Residue |
| C | ARG355 |
| C | LEU356 |
| C | HOH848 |
| site_id | AJ5 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 732 |
| Chain | Residue |
| C | THR254 |
| C | TYR255 |
| C | ASN256 |
| C | HOH1049 |
| site_id | AJ6 |
| Number of Residues | 1 |
| Details | binding site for residue CL C 733 |
| site_id | AJ7 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 734 |
| Chain | Residue |
| C | ARG96 |
| C | TYR280 |
| C | ASP283 |
| site_id | AJ8 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 735 |
| Chain | Residue |
| C | GLY76 |
| C | GLU299 |
| C | LYS313 |
| site_id | AJ9 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 736 |
| Chain | Residue |
| C | TRP48 |
| C | ASN308 |
| C | PEG721 |
| site_id | AK1 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 737 |
| Chain | Residue |
| C | ASP283 |
| C | ASP284 |
| C | LEU314 |
| C | PEG720 |
| site_id | AK2 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 702 |
| site_id | AK3 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 703 |
| site_id | AK4 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 704 |
| site_id | AK5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 705 |
| Chain | Residue |
| A | ARG31 |
| A | GLU136 |
| A | PRO139 |
| A | LYS143 |
| site_id | AK6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 706 |
| Chain | Residue |
| A | THR254 |
| A | TYR255 |
| A | ASN256 |
| site_id | AK7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 707 |
| Chain | Residue |
| A | GLY201 |
| A | GLU202 |
| A | GLY203 |
| A | THR204 |
| A | PHE218 |
| A | LYS219 |
| A | ALA220 |
| site_id | AK8 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 708 |
| Chain | Residue |
| A | ARG405 |
| A | GLY409 |
| A | THR418 |
| A | ALA419 |
| A | ILE420 |
| A | THR613 |
| A | HOH805 |
| A | HOH869 |
| A | HOH977 |
| site_id | AK9 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 709 |
| site_id | AL1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 710 |
| Chain | Residue |
| A | GLU45 |
| A | PRO46 |
| A | ASP47 |
| A | TYR85 |
| A | CL725 |
| site_id | AL2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 711 |
| Chain | Residue |
| A | ASP80 |
| A | LYS623 |
| A | PHE625 |
| A | SER626 |
| A | LYS655 |
| A | HOH967 |
| site_id | AL3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 713 |
| Chain | Residue |
| A | SER492 |
| A | HOH976 |
| site_id | AL4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 714 |
| Chain | Residue |
| A | ASN27 |
| A | PRO79 |
| A | PG4724 |
| site_id | AL5 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 715 |
| Chain | Residue |
| A | PRO264 |
| A | GLU265 |
| A | TYR266 |
| A | MET267 |
| A | PRO277 |
| A | VAL278 |
| A | SER279 |
| A | TYR280 |
| A | HOH957 |
| site_id | AL6 |
| Number of Residues | 18 |
| Details | binding site for residue BQZ A 716 |
| Chain | Residue |
| A | TRP110 |
| A | GLY111 |
| A | TRP317 |
| A | ARG320 |
| A | ASN333 |
| A | GLU335 |
| A | ASN484 |
| A | TYR487 |
| A | SER515 |
| A | ARG533 |
| A | TRP639 |
| A | GLU641 |
| A | HOH808 |
| A | HOH811 |
| A | HOH889 |
| A | HOH910 |
| A | HOH955 |
| A | HOH981 |
| site_id | AL7 |
| Number of Residues | 2 |
| Details | binding site for residue CA A 717 |
| Chain | Residue |
| A | ASP410 |
| A | GLY415 |
| site_id | AL8 |
| Number of Residues | 3 |
| Details | binding site for residue CA A 718 |
| Chain | Residue |
| A | ARG96 |
| A | TYR280 |
| A | ASP283 |
| site_id | AL9 |
| Number of Residues | 2 |
| Details | binding site for residue CA A 719 |
| Chain | Residue |
| A | LEU127 |
| A | VAL130 |
| site_id | AM1 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 720 |
| Chain | Residue |
| A | ASP458 |
| A | ASP460 |
| A | ASP462 |
| A | PHE464 |
| A | ASN466 |
| A | ASN476 |
| site_id | AM2 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 721 |
| Chain | Residue |
| A | ALA182 |
| A | VAL183 |
| A | ASP185 |
| A | VAL188 |
| A | HOH827 |
| site_id | AM3 |
| Number of Residues | 2 |
| Details | binding site for residue PEG A 722 |
| Chain | Residue |
| A | ASN485 |
| A | GLY486 |
| site_id | AM4 |
| Number of Residues | 4 |
| Details | binding site for residue P4G A 723 |
| Chain | Residue |
| A | GLU338 |
| A | ASN339 |
| A | SER343 |
| A | ARG346 |
| site_id | AM5 |
| Number of Residues | 12 |
| Details | binding site for residue PG4 A 724 |
| Chain | Residue |
| A | ASN27 |
| A | GLY76 |
| A | ASN77 |
| A | SER279 |
| A | TYR280 |
| A | ARG281 |
| A | LEU661 |
| A | PHE662 |
| A | EDO714 |
| A | HOH810 |
| A | HOH873 |
| A | HOH957 |
| site_id | AM6 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 725 |
| Chain | Residue |
| A | TRP48 |
| A | ASN308 |
| A | EDO710 |
| site_id | AM7 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 726 |
| Chain | Residue |
| A | VAL84 |
| A | GLY86 |
| A | TRP650 |
| A | VAL651 |
| A | GLN656 |
| site_id | AM8 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 727 |
| Chain | Residue |
| A | GLY76 |
| A | GLU299 |
| A | LYS313 |
| site_id | AM9 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 728 |
| Chain | Residue |
| A | TYR523 |
| A | ARG532 |
