6EOP
DPP8 - SLRFLYEG, space group 20
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006508 | biological_process | proteolysis |
| A | 0006915 | biological_process | apoptotic process |
| A | 0006955 | biological_process | immune response |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| A | 0043069 | biological_process | negative regulation of programmed cell death |
| B | 0004177 | molecular_function | aminopeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006508 | biological_process | proteolysis |
| B | 0006915 | biological_process | apoptotic process |
| B | 0006955 | biological_process | immune response |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| B | 0043069 | biological_process | negative regulation of programmed cell death |
| C | 0004177 | molecular_function | aminopeptidase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006508 | biological_process | proteolysis |
| C | 0006915 | biological_process | apoptotic process |
| C | 0006955 | biological_process | immune response |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| C | 0043069 | biological_process | negative regulation of programmed cell death |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue FLC A 901 |
| Chain | Residue |
| A | HIS172 |
| A | PRO222 |
| A | ALA223 |
| A | PRO287 |
| A | LYS288 |
| A | ALA289 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 902 |
| Chain | Residue |
| A | TYR280 |
| A | HOH1019 |
| A | ARG158 |
| A | GLN274 |
| A | ASP278 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 901 |
| Chain | Residue |
| B | ARG158 |
| B | GLN274 |
| B | GLU275 |
| B | ASP278 |
| B | TYR280 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue CA C 901 |
| Chain | Residue |
| C | ARG158 |
| C | GLN274 |
| C | ASP278 |
| C | TYR280 |
| C | HOH1042 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue F15 D 101 |
| Chain | Residue |
| A | PHE667 |
| A | TYR669 |
| A | VAL674 |
| A | TYR686 |
| A | ARG688 |
| A | TYR876 |
| D | ARG12 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue F15 E 101 |
| Chain | Residue |
| B | TYR669 |
| B | TYR686 |
| B | ARG688 |
| B | TYR876 |
| E | ARG12 |
| E | PHE13 |
| E | HOH201 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue F15 F 101 |
| Chain | Residue |
| C | TYR686 |
| C | ARG688 |
| C | TYR876 |
| C | LEU880 |
| F | ARG12 |
| F | PHE13 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | ACT_SITE: Charge relay system => ECO:0000305|PubMed:12534281, ECO:0000305|PubMed:29382749 |
| Chain | Residue | Details |
| A | SER755 | |
| A | ASP833 | |
| A | HIS865 | |
| B | SER755 | |
| B | ASP833 | |
| B | HIS865 | |
| C | SER755 | |
| C | ASP833 | |
| C | HIS865 |
