Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6ENP

Atomic resolution structure of human RNase 6 in the presence of phosphate anions in P21 space group.

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0004519molecular_functionendonuclease activity
A0004540molecular_functionRNA nuclease activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005764cellular_componentlysosome
A0006401biological_processRNA catabolic process
A0006952biological_processdefense response
A0019731biological_processantibacterial humoral response
A0031410cellular_componentcytoplasmic vesicle
A0042742biological_processdefense response to bacterium
A0045087biological_processinnate immune response
A0050829biological_processdefense response to Gram-negative bacterium
A0050830biological_processdefense response to Gram-positive bacterium
A0051607biological_processdefense response to virus
A0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue PO4 A 201
ChainResidue
AHIS36
AARG66
AHIS67
ASER112
AHOH301
AHOH316
AHOH434

site_idAC2
Number of Residues8
Detailsbinding site for residue PO4 A 202
ChainResidue
ALYS111
AHOH303
AHOH322
AHOH365
AHOH373
AHOH432
ASER59
AGLN110

site_idAC3
Number of Residues8
Detailsbinding site for residue PO4 A 203
ChainResidue
AARG25
AARG92
AHOH312
AHOH330
AHOH349
AHOH388
AHOH402
AHOH423

site_idAC4
Number of Residues5
Detailsbinding site for residue ZN A 204
ChainResidue
ALEU5
ATHR6
AHIS9
AHIS39
AHOH488

site_idAC5
Number of Residues5
Detailsbinding site for residue NA A 205
ChainResidue
AARG66
AASN68
ACYS106
AASP107
AHOH516

site_idAC6
Number of Residues8
Detailsbinding site for residue NA A 206
ChainResidue
AGLN17
APRO18
ASER19
AASP46
AALA97
ACL208
AHOH347
AHOH430

site_idAC7
Number of Residues5
Detailsbinding site for residue NA A 207
ChainResidue
AASN32
ALEU58
AGLN71
AHOH332
AHOH505

site_idAC8
Number of Residues6
Detailsbinding site for residue CL A 208
ChainResidue
AILE16
AGLN17
APRO18
AASP46
ANA206
AHOH394

Functional Information from PROSITE/UniProt
site_idPS00127
Number of Residues7
DetailsRNASE_PANCREATIC Pancreatic ribonuclease family signature. CKhqNTF
ChainResidueDetails
ACYS37-PHE43

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:Q64438
ChainResidueDetails
AHIS15

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q64438
ChainResidueDetails
AHIS122

site_idSWS_FT_FI3
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ALYS38
ALYS63
AARG82

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Important for bactericidal activity, bacterial agglutination activity and binding to bacterial lipopolysaccharide (LPS) => ECO:0000269|PubMed:27089320
ChainResidueDetails
ATRP1
AILE13

site_idSWS_FT_FI5
Number of Residues1
DetailsSITE: Facilitates cleavage of polynucleotide substrates => ECO:0000269|PubMed:27013146
ChainResidueDetails
AHIS36

site_idSWS_FT_FI6
Number of Residues1
DetailsSITE: Critical for catalytic activity => ECO:0000250|UniProtKB:Q9H1E1
ChainResidueDetails
ALYS38

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN32
AASN77

222036

PDB entries from 2024-07-03

PDB statisticsPDBj update infoContact PDBjnumon