Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6EL3

Structure of Progesterone 5beta-Reductase from Arabidopsis thaliana in complex with NADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0008202	biological_process	steroid metabolic process
A	0009611	biological_process	response to wounding
A	0010051	biological_process	xylem and phloem pattern formation
A	0016491	molecular_function	oxidoreductase activity
A	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
A	0035671	molecular_function	enone reductase activity
A	0046983	molecular_function	protein dimerization activity
A	0047787	molecular_function	Delta4-3-oxosteroid 5beta-reductase activity
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0008202	biological_process	steroid metabolic process
B	0009611	biological_process	response to wounding
B	0010051	biological_process	xylem and phloem pattern formation
B	0016491	molecular_function	oxidoreductase activity
B	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
B	0035671	molecular_function	enone reductase activity
B	0046983	molecular_function	protein dimerization activity
B	0047787	molecular_function	Delta4-3-oxosteroid 5beta-reductase activity
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0008202	biological_process	steroid metabolic process
C	0009611	biological_process	response to wounding
C	0010051	biological_process	xylem and phloem pattern formation
C	0016491	molecular_function	oxidoreductase activity
C	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
C	0035671	molecular_function	enone reductase activity
C	0046983	molecular_function	protein dimerization activity
C	0047787	molecular_function	Delta4-3-oxosteroid 5beta-reductase activity
D	0005829	cellular_component	cytosol
D	0006629	biological_process	lipid metabolic process
D	0008202	biological_process	steroid metabolic process
D	0009611	biological_process	response to wounding
D	0010051	biological_process	xylem and phloem pattern formation
D	0016491	molecular_function	oxidoreductase activity
D	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
D	0035671	molecular_function	enone reductase activity
D	0046983	molecular_function	protein dimerization activity
D	0047787	molecular_function	Delta4-3-oxosteroid 5beta-reductase activity
E	0005829	cellular_component	cytosol
E	0006629	biological_process	lipid metabolic process
E	0008202	biological_process	steroid metabolic process
E	0009611	biological_process	response to wounding
E	0010051	biological_process	xylem and phloem pattern formation
E	0016491	molecular_function	oxidoreductase activity
E	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
E	0035671	molecular_function	enone reductase activity
E	0046983	molecular_function	protein dimerization activity
E	0047787	molecular_function	Delta4-3-oxosteroid 5beta-reductase activity
F	0005829	cellular_component	cytosol
F	0006629	biological_process	lipid metabolic process
F	0008202	biological_process	steroid metabolic process
F	0009611	biological_process	response to wounding
F	0010051	biological_process	xylem and phloem pattern formation
F	0016491	molecular_function	oxidoreductase activity
F	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
F	0035671	molecular_function	enone reductase activity
F	0046983	molecular_function	protein dimerization activity
F	0047787	molecular_function	Delta4-3-oxosteroid 5beta-reductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	33
Details	binding site for residue NAP A 401

Chain	Residue
A	GLY33
A	VAL82
A	VAL104
A	THR105
A	TRP106
A	GLN143
A	THR144
A	MLY147
A	TYR178
A	PRO202
A	ASN203
A	THR35
A	ILE205
A	SER212
A	LEU213
A	MET214
A	CL402
A	HOH578
A	HOH587
A	HOH612
A	HOH613
A	HOH628
A	GLY36
A	HOH657
A	HOH679
A	HOH693
A	HOH708
A	ILE37
A	ALA62
A	ARG63
A	ARG64
A	CYS80
A	ASP81

site_id	AC2
Number of Residues	5
Details	binding site for residue CL A 402

Chain	Residue
A	GLY145
A	THR146
A	MLY147
A	TYR178
A	NAP401

site_id	AC3
Number of Residues	34
Details	binding site for residue NAP B 401

Chain	Residue
B	GLY33
B	THR35
B	GLY36
B	ILE37
B	ALA62
B	ARG63
B	ARG64
B	CYS80
B	ASP81
B	VAL82
B	VAL104
B	THR105
B	TRP106
B	MET122
B	GLN143
B	THR144
B	MLY147
B	TYR178
B	PRO202
B	ASN203
B	ILE205
B	SER212
B	LEU213
B	MET214
B	CL402
B	HOH549
B	HOH598
B	HOH605
B	HOH627
B	HOH645
B	HOH674
B	HOH685
B	HOH686
B	HOH700

site_id	AC4
Number of Residues	5
Details	binding site for residue CL B 402

Chain	Residue
B	GLY145
B	THR146
B	MLY147
B	TYR178
B	NAP401

site_id	AC5
Number of Residues	34
Details	binding site for residue NAP C 401

Chain	Residue
C	LEU213
C	MET214
C	CL402
C	HOH588
C	HOH590
C	HOH613
C	HOH620
C	HOH632
C	HOH646
C	HOH654
C	HOH661
C	HOH709
C	GLY33
C	THR35
C	GLY36
C	ILE37
C	ALA62
C	ARG63
C	ARG64
C	CYS80
C	ASP81
C	VAL82
C	VAL104
C	THR105
C	TRP106
C	MET122
C	GLN143
C	THR144
C	MLY147
C	TYR178
C	PRO202
C	ASN203
C	ILE205
C	SER212

site_id	AC6
Number of Residues	5
Details	binding site for residue CL C 402

Chain	Residue
C	GLY145
C	THR146
C	MLY147
C	TYR178
C	NAP401

site_id	AC7
Number of Residues	34
Details	binding site for residue NAP D 401

Chain	Residue
D	GLY33
D	VAL34
D	THR35
D	GLY36
D	ILE37
D	ALA62
D	ARG63
D	ARG64
D	CYS80
D	ASP81
D	VAL82
D	VAL104
D	THR105
D	TRP106
D	GLN143
D	THR144
D	MLY147
D	TYR178
D	PRO202
D	ASN203
D	ILE205
D	SER212
D	LEU213
D	MET214
D	CL402
D	HOH533
D	HOH541
D	HOH618
D	HOH623
D	HOH630
D	HOH661
D	HOH681
D	HOH683
D	HOH772

site_id	AC8
Number of Residues	5
Details	binding site for residue CL D 402

Chain	Residue
D	GLY145
D	THR146
D	MLY147
D	TYR178
D	NAP401

site_id	AC9
Number of Residues	33
Details	binding site for residue NAP E 401

Chain	Residue
E	GLY33
E	THR35
E	GLY36
E	ILE37
E	ALA62
E	ARG63
E	ARG64
E	CYS80
E	ASP81
E	VAL82
E	VAL104
E	THR105
E	TRP106
E	GLN143
E	THR144
E	MLY147
E	TYR178
E	PRO202
E	ASN203
E	ILE205
E	SER212
E	LEU213
E	MET214
E	CL402
E	HOH575
E	HOH593
E	HOH638
E	HOH655
E	HOH662
E	HOH663
E	HOH685
E	HOH702
E	HOH744

site_id	AD1
Number of Residues	5
Details	binding site for residue CL E 402

Chain	Residue
E	GLY145
E	THR146
E	MLY147
E	TYR178
E	NAP401

site_id	AD2
Number of Residues	34
Details	binding site for residue NAP F 401

Chain	Residue
F	GLY33
F	VAL34
F	THR35
F	GLY36
F	ILE37
F	ALA62
F	ARG63
F	ARG64
F	CYS80
F	ASP81
F	VAL82
F	VAL104
F	THR105
F	TRP106
F	GLN143
F	THR144
F	MLY147
F	TYR178
F	PRO202
F	ASN203
F	ILE205
F	SER212
F	LEU213
F	MET214
F	CL402
F	HOH550
F	HOH578
F	HOH583
F	HOH584
F	HOH594
F	HOH609
F	HOH616
F	HOH638
F	HOH704

site_id	AD3
Number of Residues	5
Details	binding site for residue CL F 402

Chain	Residue
F	GLY145
F	THR146
F	MLY147
F	TYR178
F	NAP401

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000250\|UniProtKB:K7WDL7

Chain	Residue	Details
F	HIS148
F	TYR179

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:30172078, ECO:0007744\|PDB:6EL3

Chain	Residue	Details
F	GLY36
F	ARG64
F	VAL82
F	TRP106
F	THR144
F	TYR179
F	PHE206
F	LEU213

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)