6EJZ
Tryptophan Repressor TrpR from E.coli variant S88Y with Indole-3-acetic acid as ligand
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0043565 | molecular_function | sequence-specific DNA binding |
| C | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0043565 | molecular_function | sequence-specific DNA binding |
| D | 0045892 | biological_process | negative regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue IAC A 201 |
| Chain | Residue |
| A | ARG54 |
| A | ARG84 |
| A | GLY85 |
| A | TYR88 |
| A | HOH307 |
| C | LEU41 |
| C | MET42 |
| C | THR44 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 202 |
| Chain | Residue |
| A | ILE79 |
| A | ALA80 |
| A | THR81 |
| A | GLY78 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 203 |
| Chain | Residue |
| A | ARG54 |
| A | HOH307 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 204 |
| Chain | Residue |
| A | SER8 |
| A | HOH320 |
| C | LEU89 |
| C | ALA92 |
| C | ARG97 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue IAC B 201 |
| Chain | Residue |
| B | ARG54 |
| B | ARG84 |
| B | GLY85 |
| B | TYR88 |
| B | HOH331 |
| D | LEU41 |
| D | MET42 |
| D | THR44 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 202 |
| Chain | Residue |
| B | GLY78 |
| B | THR81 |
| B | ARG84 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 203 |
| Chain | Residue |
| B | TYR7 |
| B | SER8 |
| D | ARG97 |
| D | GLN98 |
| D | GLU101 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 204 |
| Chain | Residue |
| B | ARG54 |
| B | HOH328 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue IAC C 201 |
| Chain | Residue |
| A | LEU41 |
| A | MET42 |
| A | THR44 |
| C | ARG54 |
| C | ARG84 |
| C | GLY85 |
| C | TYR88 |
| C | HOH325 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 202 |
| Chain | Residue |
| C | GLY78 |
| C | ALA80 |
| C | THR81 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 203 |
| Chain | Residue |
| C | ARG54 |
| C | HOH307 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 204 |
| Chain | Residue |
| A | ARG97 |
| C | SER8 |
| C | ALA9 |
| C | ALA10 |
| D | GLN31 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 205 |
| Chain | Residue |
| B | ARG97 |
| C | GLN31 |
| D | SER8 |
| D | ALA9 |
| D | HOH333 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue IAC D 201 |
| Chain | Residue |
| B | LEU41 |
| B | MET42 |
| B | THR44 |
| D | ARG54 |
| D | ARG84 |
| D | GLY85 |
| D | TYR88 |
| D | HOH336 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 202 |
| Chain | Residue |
| D | GLY78 |
| D | ILE79 |
| D | ALA80 |
| D | THR81 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 203 |
| Chain | Residue |
| D | THR53 |
| D | ARG54 |
| D | HOH312 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 204 |
| Chain | Residue |
| A | HIS35 |
| C | LYS27 |
| D | HIS16 |
| D | IAC205 |
| site_id | AD9 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide IAC D 205 and ARG D 15 |
| Chain | Residue |
| B | PRO45 |
| B | GLU49 |
| B | HOH316 |
| D | MET11 |
| D | ALA12 |
| D | GLU13 |
| D | GLN14 |
| D | HIS16 |
| D | GLN17 |
| D | GLU18 |
| D | TRP19 |
| D | EDO204 |
| D | HOH337 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 92 |
| Details | DNA_BIND: |
| Chain | Residue | Details |
| A | GLN68-ALA91 | |
| B | GLN68-ALA91 | |
| C | GLN68-ALA91 | |
| D | GLN68-ALA91 |
