6EJW
Tryptophan Repressor TrpR from E.coli wildtype with Indole-3-acetic acid as ligand
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0043565 | molecular_function | sequence-specific DNA binding |
| C | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0043565 | molecular_function | sequence-specific DNA binding |
| D | 0045892 | biological_process | negative regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue IAC A 201 |
| Chain | Residue |
| A | ARG54 |
| A | ILE57 |
| A | VAL58 |
| A | THR81 |
| A | ARG84 |
| A | GLY85 |
| A | HOH324 |
| B | LEU41 |
| B | THR44 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue IAC A 203 |
| Chain | Residue |
| A | ARG15 |
| A | HIS16 |
| B | PRO45 |
| B | GLU49 |
| B | LYS90 |
| B | HOH309 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue IAC B 201 |
| Chain | Residue |
| A | LEU41 |
| A | MET42 |
| A | THR44 |
| B | ARG54 |
| B | ILE57 |
| B | THR81 |
| B | ARG84 |
| B | GLY85 |
| B | HOH321 |
| B | HOH326 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue IAC C 201 |
| Chain | Residue |
| C | ARG54 |
| C | THR81 |
| C | ARG84 |
| C | GLY85 |
| C | HOH317 |
| D | LEU41 |
| D | MET42 |
| D | THR44 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue IAC D 201 |
| Chain | Residue |
| C | LEU41 |
| C | THR44 |
| C | ARG84 |
| D | ARG54 |
| D | ILE57 |
| D | ARG84 |
| D | GLY85 |
| site_id | AC6 |
| Number of Residues | 22 |
| Details | binding site for Di-peptide IAC A 202 and VAL B 94 |
| Chain | Residue |
| A | SER8 |
| A | ALA9 |
| A | ALA92 |
| A | PRO93 |
| A | GLU95 |
| A | LEU96 |
| A | ARG97 |
| A | GLN98 |
| A | HOH325 |
| A | HOH327 |
| A | HOH337 |
| B | ALA92 |
| B | PRO93 |
| B | GLU95 |
| B | LEU96 |
| B | ARG97 |
| B | ARG97 |
| B | GLN98 |
| B | GLN98 |
| C | ASN28 |
| C | GLN31 |
| C | GLN31 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide IAC C 202 and GLY C 78 |
| Chain | Residue |
| C | ALA77 |
| C | ILE79 |
| C | ALA80 |
| C | THR81 |
| C | ILE82 |
| C | ARG84 |
| C | HOH341 |
| D | ALA80 |
| D | ARG84 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 92 |
| Details | DNA binding: {} |
| Chain | Residue | Details |
