6EIB

Structure of the active GGEEF domain of a diguanylate cyclase from Vibrio cholerae.

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 A 201

Chain	Residue
A	PRO28
A	HIS88
A	VAL89
A	SER123
A	HOH308
A	HOH325

---

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 202

Chain	Residue
A	HOH307
A	HOH358
A	ARG102
A	HIS106
A	HOH305

---

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 A 203

Chain	Residue
A	ARG136
A	GLN140
A	TYR156
A	GLN158
A	HOH304
D	GLY77

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 204

Chain	Residue
A	ARG8
A	ARG74
A	GLY76
A	GLY77
D	HOH368

---

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO A 205

Chain	Residue
A	TYR116
A	ARG150
A	ASN151
C	ARG100
C	GLN101
C	EDO207

---

site_id	AC6
Number of Residues	2
Details	binding site for residue EDO A 206

Chain	Residue
A	ALA17
A	EDO209

---

site_id	AC7
Number of Residues	6
Details	binding site for residue EDO A 207

Chain	Residue
A	HIS114
A	ARG150
A	HOH312
A	HOH343
C	PHE93
C	HIS94

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO A 208

Chain	Residue
A	ARG9
D	LYS23
D	ASP128
D	HIS129
D	HOH353

---

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO A 209

Chain	Residue
A	ALA13
A	ASP14
A	EDO206
A	HOH322

---

site_id	AD1
Number of Residues	3
Details	binding site for residue EDO A 210

Chain	Residue
A	HIS94
A	GLU97
A	GLN98

---

site_id	AD2
Number of Residues	2
Details	binding site for residue EDO A 211

Chain	Residue
A	LYS23
A	HIS126

---

site_id	AD3
Number of Residues	3
Details	binding site for residue ACT A 212

Chain	Residue
A	ARG100
A	GLN101
A	HOH342

---

site_id	AD4
Number of Residues	6
Details	binding site for residue SO4 B 201

Chain	Residue
B	PRO28
B	HIS88
B	VAL89
B	GLU90
B	SER123
B	HOH364

---

site_id	AD5
Number of Residues	3
Details	binding site for residue SO4 B 202

Chain	Residue
B	ARG102
B	HIS106
B	HOH338

---

site_id	AD6
Number of Residues	5
Details	binding site for residue SO4 B 203

Chain	Residue
B	ASN7
B	ARG9
B	HOH304
B	HOH306
B	HOH322

---

site_id	AD7
Number of Residues	8
Details	binding site for residue SO4 B 204

Chain	Residue
B	ARG136
B	GLN140
B	TYR156
B	GLN158
B	HOH325
B	HOH384
C	GLY76
C	GLY77

---

site_id	AD8
Number of Residues	8
Details	binding site for residue SO4 B 205

Chain	Residue
B	ASN38
B	LYS40
B	LEU41
B	HOH302
B	HOH313
B	HOH356
B	HOH359
D	ARG157

---

site_id	AD9
Number of Residues	2
Details	binding site for residue SO4 B 206

Chain	Residue
B	ARG100
B	GLN101

---

site_id	AE1
Number of Residues	2
Details	binding site for residue EDO B 207

Chain	Residue
B	HIS126
B	GLY127

---

site_id	AE2
Number of Residues	3
Details	binding site for residue EDO B 208

Chain	Residue
B	ARG9
B	HOH301
B	HOH349

---

site_id	AE3
Number of Residues	4
Details	binding site for residue EDO B 209

Chain	Residue
B	GLY47
B	HIS48
B	ASP49
B	HOH379

---

site_id	AE4
Number of Residues	3
Details	binding site for residue EDO B 210

Chain	Residue
B	HIS125
B	HIS126
B	HOH327

---

site_id	AE5
Number of Residues	1
Details	binding site for residue EDO B 211

Chain	Residue
B	ARG147

---

site_id	AE6
Number of Residues	5
Details	binding site for residue EDO B 212

Chain	Residue
B	SER159
B	THR160
B	GLU161
B	HOH398
B	GLN158

---

site_id	AE7
Number of Residues	6
Details	binding site for residue ACT B 213

Chain	Residue
B	ARG8
B	VAL75
C	ARG137
C	SO4203
C	HOH347
C	HOH354

---

site_id	AE8
Number of Residues	7
Details	binding site for residue SO4 C 201

Chain	Residue
C	PRO28
C	HIS88
C	VAL89
C	GLU90
C	SER123
C	HOH330
C	HOH358

---

site_id	AE9
Number of Residues	5
Details	binding site for residue SO4 C 202

Chain	Residue
C	LYS144
C	ARG147
C	ASN148
D	LYS144
D	ARG147

---

site_id	AF1
Number of Residues	8
Details	binding site for residue SO4 C 203

Chain	Residue
B	GLY76
B	GLY77
B	ACT213
C	ARG136
C	TYR156
C	GLN158
C	HOH341
C	HOH354

---

site_id	AF2
Number of Residues	5
Details	binding site for residue SO4 C 204

Chain	Residue
B	HOH324
C	ARG9
C	ARG16
C	HOH301
C	HOH317

---

site_id	AF3
Number of Residues	7
Details	binding site for residue SO4 C 205

Chain	Residue
C	ASP35
C	ASP37
C	ASN38
C	LYS146
C	HOH309
C	HOH312
C	HOH334

---

site_id	AF4
Number of Residues	3
Details	binding site for residue EDO C 206

Chain	Residue
C	GLN140
C	TYR156
C	ARG157

---

site_id	AF5
Number of Residues	6
Details	binding site for residue EDO C 207

Chain	Residue
A	ARG152
A	EDO205
A	HOH349
C	ARG100
C	GLN101
C	ASN151

---

site_id	AF6
Number of Residues	2
Details	binding site for residue EDO C 208

Chain	Residue
B	HOH371
C	ARG9

---

site_id	AF7
Number of Residues	2
Details	binding site for residue EDO C 209

Chain	Residue
C	GLN101
C	HOH313

---

site_id	AF8
Number of Residues	4
Details	binding site for residue EDO C 210

Chain	Residue
C	PHE57
C	ARG102
C	HIS106
C	HOH311

---

site_id	AF9
Number of Residues	4
Details	binding site for residue EDO C 211

Chain	Residue
A	GLN111
C	THR91
C	HIS94
C	HOH416

---

site_id	AG1
Number of Residues	2
Details	binding site for residue EDO C 212

Chain	Residue
C	PHE108
C	PHE109

---

site_id	AG2
Number of Residues	5
Details	binding site for residue SO4 D 201

Chain	Residue
D	HIS88
D	VAL89
D	SER123
D	HOH303
D	HOH331

---

site_id	AG3
Number of Residues	8
Details	binding site for residue SO4 D 202

Chain	Residue
A	GLY76
A	GLY77
D	ARG136
D	TYR156
D	GLN158
D	HOH348
D	HOH349
D	HOH368

---

site_id	AG4
Number of Residues	5
Details	binding site for residue SO4 D 203

Chain	Residue
D	ASP35
D	ASP37
D	ASN38
D	LYS146
D	HOH311

---

site_id	AG5
Number of Residues	4
Details	binding site for residue EDO D 204

Chain	Residue
D	GLN140
D	TYR156
D	ARG157
D	HOH347

---

site_id	AG6
Number of Residues	4
Details	binding site for residue EDO D 205

Chain	Residue
B	ASN151
B	ARG152
B	HOH370
D	ARG100

---

site_id	AG7
Number of Residues	3
Details	binding site for residue ACT D 206

Chain	Residue
D	ARG9
D	ARG16
D	HOH304

---

Functional Information from PROSITE/UniProt

site_id	PS01171
Number of Residues	26
Details	RIBOSOMAL_L21E Ribosomal protein L21e signature. GDeVlcflaklfqs.VisDhhFcGrVG

Chain	Residue	Details
A	GLY51-GLY76

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	524
Details	Domain: {"description":"GGDEF","evidences":[{"source":"PROSITE-ProRule","id":"PRU00095","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P31129","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---