6EI1
Crystal structure of the covalent complex between deubiquitinase ZUFSP (ZUP1) and Ubiquitin-PA
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue AYE A 601 |
| Chain | Residue |
| A | TRP358 |
| A | CYS360 |
| A | TRP423 |
| A | GLY490 |
| A | HIS491 |
| B | GLY75 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 602 |
| Chain | Residue |
| A | SER569 |
| A | PHE572 |
| A | THR573 |
| A | HOH728 |
| A | HOH746 |
| A | HOH761 |
| A | TYR430 |
| A | HIS441 |
| A | ILE442 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue MLI A 603 |
| Chain | Residue |
| A | GLN489 |
| A | HIS545 |
| A | LYS546 |
| A | HOH756 |
| A | HOH773 |
| A | HOH782 |
| A | HOH846 |
| B | ARG42 |
| B | GLN49 |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| B | LYS27-ASP52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | Region: {"description":"zUBD/ZHA","evidences":[{"source":"PubMed","id":"29476094","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29576527","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"29476094","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"29476094","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"Q99K23","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole","evidences":[{"source":"PubMed","id":"29576527","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
