6EHQ

E. coli Hydrogenase-2 (as isolated form).

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0005515	molecular_function	protein binding
L	0005886	cellular_component	plasma membrane
L	0008901	molecular_function	ferredoxin hydrogenase activity
L	0016151	molecular_function	nickel cation binding
L	0016491	molecular_function	oxidoreductase activity
L	0033748	molecular_function	hydrogenase (acceptor) activity
L	0046872	molecular_function	metal ion binding
M	0005515	molecular_function	protein binding
M	0005886	cellular_component	plasma membrane
M	0008901	molecular_function	ferredoxin hydrogenase activity
M	0016151	molecular_function	nickel cation binding
M	0016491	molecular_function	oxidoreductase activity
M	0033748	molecular_function	hydrogenase (acceptor) activity
M	0046872	molecular_function	metal ion binding
S	0008901	molecular_function	ferredoxin hydrogenase activity
S	0009375	cellular_component	ferredoxin hydrogenase complex
S	0051536	molecular_function	iron-sulfur cluster binding
T	0008901	molecular_function	ferredoxin hydrogenase activity
T	0009375	cellular_component	ferredoxin hydrogenase complex
T	0051536	molecular_function	iron-sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue SF4 S 401

Chain	Residue
S	HIS192
S	CYS195
S	ARG197
S	ARG198
S	CYS220
S	LEU221
S	TYR222
S	CYS226

---

site_id	AC2
Number of Residues	7
Details	binding site for residue F3S S 402

Chain	Residue
S	CYS235
S	PHE240
S	CYS255
S	TYR256
S	CYS258
S	ASN259
L	GLN216

---

site_id	AC3
Number of Residues	13
Details	binding site for residue SF4 S 403

Chain	Residue
L	ARG59
L	HIS214
S	GLU21
S	CYS22
S	CYS25
S	ASP81
S	GLY118
S	SER119
S	CYS120
S	GLY153
S	CYS154
S	PRO155
S	HOH501

---

site_id	AC4
Number of Residues	13
Details	binding site for residue FCO L 601

Chain	Residue
L	CYS64
L	THR67
L	HIS68
L	ALA477
L	PRO478
L	ARG479
L	LEU482
L	VAL500
L	PRO501
L	SER502
L	CYS549
L	NI602
L	HOH868

---

site_id	AC5
Number of Residues	6
Details	binding site for residue NI L 602

Chain	Residue
L	CYS61
L	CYS64
L	CYS546
L	CYS549
L	FCO601
L	HOH868

---

site_id	AC6
Number of Residues	6
Details	binding site for residue MG L 603

Chain	Residue
L	GLU42
L	ALA498
L	HIS552
L	HOH710
L	HOH713
L	HOH740

---

site_id	AC7
Number of Residues	7
Details	binding site for residue SF4 T 401

Chain	Residue
T	HIS192
T	CYS195
T	ARG197
T	ARG198
T	CYS220
T	LEU221
T	CYS226

---

site_id	AC8
Number of Residues	8
Details	binding site for residue F3S T 402

Chain	Residue
T	CYS235
T	PHE240
T	CYS255
T	TYR256
T	GLY257
T	CYS258
T	ASN259
M	GLN216

---

site_id	AC9
Number of Residues	11
Details	binding site for residue SF4 T 403

Chain	Residue
T	CYS22
T	THR23
T	GLY24
T	CYS25
T	ASP81
T	SER119
T	CYS120
T	GLY153
T	CYS154
T	PRO155
M	ARG59

---

site_id	AD1
Number of Residues	13
Details	binding site for residue FCO M 601

Chain	Residue
M	CYS64
M	THR67
M	HIS68
M	ALA477
M	PRO478
M	ARG479
M	LEU482
M	VAL500
M	PRO501
M	SER502
M	CYS549
M	NI602
M	HOH831

---

site_id	AD2
Number of Residues	6
Details	binding site for residue NI M 602

Chain	Residue
M	CYS61
M	CYS64
M	CYS546
M	CYS549
M	FCO601
M	HOH831

---

site_id	AD3
Number of Residues	6
Details	binding site for residue MG M 603

Chain	Residue
M	ALA498
M	HIS552
M	HOH706
M	HOH710
M	HOH743
M	GLU42

---

Functional Information from PROSITE/UniProt

site_id	PS00507
Number of Residues	26
Details	NI_HGENASE_L_1 Nickel-dependent hydrogenases large subunit signature 1. RGMEeivknrdprdawmivQRiCGVC

Chain	Residue	Details
L	ARG39-CYS64

---

site_id	PS00508
Number of Residues	10
Details	NI_HGENASE_L_2 Nickel-dependent hydrogenases large subunit signature 2. FDPCMACav.H

Chain	Residue	Details
L	PHE543-HIS552

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P21853","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---