Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6EF0

Yeast 26S proteasome bound to ubiquitinated substrate (1D* motor state)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000502	cellular_component	proteasome complex
A	0003674	molecular_function	molecular_function
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0003674	molecular_function	molecular_function
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0034515	cellular_component	proteasome storage granule
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0000502	cellular_component	proteasome complex
C	0003674	molecular_function	molecular_function
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0034515	cellular_component	proteasome storage granule
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0080129	biological_process	proteasome core complex assembly
D	0000502	cellular_component	proteasome complex
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0034515	cellular_component	proteasome storage granule
D	0042175	cellular_component	nuclear outer membrane-endoplasmic reticulum membrane network
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0000502	cellular_component	proteasome complex
E	0003674	molecular_function	molecular_function
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0034515	cellular_component	proteasome storage granule
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0003674	molecular_function	molecular_function
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0034515	cellular_component	proteasome storage granule
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051603	biological_process	proteolysis involved in protein catabolic process
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0051603	biological_process	proteolysis involved in protein catabolic process
H	0005524	molecular_function	ATP binding
H	0016887	molecular_function	ATP hydrolysis activity
I	0005524	molecular_function	ATP binding
I	0016887	molecular_function	ATP hydrolysis activity
J	0005524	molecular_function	ATP binding
J	0016887	molecular_function	ATP hydrolysis activity
K	0005524	molecular_function	ATP binding
K	0016887	molecular_function	ATP hydrolysis activity
L	0005524	molecular_function	ATP binding
L	0016887	molecular_function	ATP hydrolysis activity
M	0005524	molecular_function	ATP binding
M	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue ADP H 501

Chain	Residue
H	ASP210
H	ALA417
H	ARG420
I	ARG340
H	VAL211
H	GLY212
H	GLY213
H	PRO252
H	GLY253
H	THR257
H	LEU258
H	GLY416

site_id	AC2
Number of Residues	16
Details	binding site for residue ATP I 501

Chain	Residue
I	GLY185
I	ALA224
I	GLY226
I	THR227
I	GLY228
I	LYS229
I	THR230
I	LEU231
I	ASP282
I	ILE361
I	GLY389
I	ALA390
J	LEU273
J	ASN277
J	ARG306
J	ARG309

site_id	AC3
Number of Residues	18
Details	binding site for residue ATP J 501

Chain	Residue
J	MET149
J	GLY151
J	GLY192
J	THR193
J	GLY194
J	LYS195
J	THR196
J	LEU197
J	ASP248
J	GLU249
J	ILE327
J	HIS331
J	GLY355
J	ALA356
J	LYS359
K	LEU300
K	ARG330
K	ARG333

site_id	AC4
Number of Residues	13
Details	binding site for residue ATP K 501

Chain	Residue
K	VAL174
K	GLY175
K	GLY216
K	THR217
K	GLY218
K	LYS219
K	THR220
K	MET221
K	ASP272
K	GLY380
K	ALA381
L	ARG339
L	ARG342

site_id	AC5
Number of Residues	12
Details	binding site for residue ADP L 501

Chain	Residue
L	GLY184
L	PRO224
L	GLY225
L	THR226
L	GLY227
L	LYS228
L	THR229
L	LEU230
L	ILE360
L	GLY388
L	ALA389
L	ARG392

site_id	AC6
Number of Residues	13
Details	binding site for residue ADP M 501

Chain	Residue
M	VAL183
M	PRO224
M	GLY225
M	THR226
M	GLY227
M	LYS228
M	THR229
M	LEU230
M	ILE360
M	HIS364
M	GLY388
M	ALA389
M	LYS392

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdgdtVtFSPtGRlfQVEYAleA

Chain	Residue	Details
F	TYR6-ALA28
E	TYR8-ALA30
G	TYR8-ALA30
A	TYR12-ALA34
D	TYR4-ALA26
B	TYR5-ALA27
C	TYR6-SER28

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. VkVLaATNrvdvLDpALl.R

Chain	Residue	Details
M	VAL321-ARG339
K	VAL312-ARG330
L	THR321-ARG339
J	ILE288-ARG306
H	ILE349-ARG367
I	VAL322-ARG340

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkGknCVVLGCErrstlklqdtritps.KvskidshvvlsfsGlnAD

Chain	Residue	Details
D	VAL34-ASP81
C	ILE36-ASP83

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
M	GLY222
C	LYS199
C	LYS231

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:19779198

Chain	Residue	Details
M	TYR180
I	LYS255
I	LYS290

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)