6EEM
Crystal structure of Papaver somniferum tyrosine decarboxylase in complex with L-tyrosine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004837 | molecular_function | tyrosine decarboxylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016830 | molecular_function | carbon-carbon lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0004837 | molecular_function | tyrosine decarboxylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016830 | molecular_function | carbon-carbon lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue 0PR A 601 |
| Chain | Residue |
| A | TRP90 |
| A | ASP289 |
| A | ALA291 |
| A | ASN318 |
| A | HIS320 |
| A | LYS321 |
| A | LEU327 |
| A | HOH717 |
| B | VAL120 |
| B | PHE122 |
| B | TYR350 |
| A | PHE99 |
| B | LEU371 |
| B | SER372 |
| A | PRO100 |
| A | THR168 |
| A | THR169 |
| A | CYS170 |
| A | HIS205 |
| A | THR260 |
| A | THR264 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 602 |
| Chain | Residue |
| A | GLY189 |
| A | ARG190 |
| A | HOH764 |
| B | ASN218 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 603 |
| Chain | Residue |
| A | ARG393 |
| A | HOH773 |
| B | LYS149 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 604 |
| Chain | Residue |
| A | PHE395 |
| A | HIS399 |
| A | THR488 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 605 |
| Chain | Residue |
| A | LYS183 |
| A | GLY283 |
| A | ILE284 |
| A | ASP313 |
| A | HOH787 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue TYR B 601 |
| Chain | Residue |
| A | TYR350 |
| A | LEU371 |
| A | SER372 |
| B | TRP90 |
| B | TYR98 |
| B | PHE99 |
| B | PRO100 |
| B | SER101 |
| B | HIS205 |
| B | THR264 |
| B | HIS320 |
| B | LLP321 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 602 |
| Chain | Residue |
| A | ASN218 |
| A | LYS220 |
| B | GLY189 |
| B | ARG190 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 603 |
| Chain | Residue |
| A | HIS304 |
| B | PRO300 |
| B | ARG393 |
| B | ARG397 |
| B | HOH708 |
| B | HOH778 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 604 |
| Chain | Residue |
| A | PRO19 |
| B | PHE395 |
| B | HIS399 |
| B | ALA487 |
| B | THR488 |
Functional Information from PROSITE/UniProt
| site_id | PS00392 |
| Number of Residues | 22 |
| Details | DDC_GAD_HDC_YDC DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site. SFsLnahKWFfTtLDCccLWvK |
| Chain | Residue | Details |
| B | SER314-LYS335 | |
| A | SER314-LYS335 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32371491","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6EEM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"PubMed","id":"32371491","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
