6EE3
X-ray crystal structure of Pf-M1 in complex with inhibitor (6k) and catalytic zinc ion
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 1101 |
Chain | Residue |
A | HIS496 |
A | HIS500 |
A | GLU519 |
A | J4V1102 |
site_id | AC2 |
Number of Residues | 24 |
Details | binding site for residue J4V A 1102 |
Chain | Residue |
A | VAL459 |
A | GLY460 |
A | ALA461 |
A | GLU463 |
A | ARG489 |
A | HIS496 |
A | GLU497 |
A | HIS500 |
A | GLU519 |
A | GLU572 |
A | TYR575 |
A | TYR580 |
A | MET1034 |
A | ZN1101 |
A | HOH1264 |
A | HOH1415 |
A | HOH1597 |
A | HOH1728 |
A | HOH2284 |
A | THR305 |
A | GLN317 |
A | GLU319 |
A | ALA320 |
A | ASN458 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue PO4 A 1103 |
Chain | Residue |
A | PRO698 |
A | GLU699 |
A | ASN700 |
A | TYR757 |
A | HOH1777 |
A | HOH2139 |
site_id | AC4 |
Number of Residues | 9 |
Details | binding site for residue GOL A 1104 |
Chain | Residue |
A | LYS479 |
A | TYR880 |
A | VAL887 |
A | ASP888 |
A | GLN891 |
A | ARG895 |
A | TYR925 |
A | HOH1528 |
A | HOH1823 |
site_id | AC5 |
Number of Residues | 7 |
Details | binding site for residue GOL A 1105 |
Chain | Residue |
A | SER927 |
A | LEU930 |
A | SER934 |
A | THR966 |
A | ARG969 |
A | HOH1206 |
A | HOH1348 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue MG A 1106 |
Chain | Residue |
A | GLY250 |
A | HOH1457 |
A | HOH1671 |
A | HOH1679 |
A | HOH1777 |
A | HOH1944 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue MG A 1107 |
Chain | Residue |
A | HOH1296 |
A | HOH1576 |
A | HOH1922 |
A | HOH2129 |
A | HOH2343 |
A | HOH2472 |
site_id | AC8 |
Number of Residues | 7 |
Details | binding site for residue MG A 1108 |
Chain | Residue |
A | GLU957 |
A | HOH1279 |
A | HOH1386 |
A | HOH1793 |
A | HOH2211 |
A | HOH2341 |
A | HOH2382 |
site_id | AC9 |
Number of Residues | 7 |
Details | binding site for residue MG A 1109 |
Chain | Residue |
A | ASN1083 |
A | HOH1271 |
A | HOH1332 |
A | HOH1740 |
A | HOH1962 |
A | HOH2311 |
A | HOH2323 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVGHEYFHQY |
Chain | Residue | Details |
A | VAL493-TYR502 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P15144 |
Chain | Residue | Details |
A | GLU497 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000305|PubMed:19196988, ECO:0000305|PubMed:21366301, ECO:0007744|PDB:3EBH, ECO:0007744|PDB:3EBI, ECO:0007744|PDB:3Q43 |
Chain | Residue | Details |
A | GLU319 | |
A | GLY460 | |
A | GLU463 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000305|PubMed:19196988, ECO:0000305|PubMed:21366301, ECO:0007744|PDB:3EBH, ECO:0007744|PDB:3Q43 |
Chain | Residue | Details |
A | ALA461 |
Chain | Residue | Details |
A | HIS496 | |
A | HIS500 | |
A | GLU519 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | SITE: Important for substrate specificity => ECO:0000269|PubMed:23897806 |
Chain | Residue | Details |
A | VAL459 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | SITE: Transition state stabilizer => ECO:0000250|UniProtKB:P15144 |
Chain | Residue | Details |
A | TYR580 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | SITE: Cleavage => ECO:0000305|PubMed:21659511 |
Chain | Residue | Details |
A | GLN795 |