Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6ECJ

Human cytochrome c G41T

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
A	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
A	0006915	biological_process	apoptotic process
A	0008635	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
A	0009055	molecular_function	electron transfer activity
A	0020037	molecular_function	heme binding
A	0043293	cellular_component	apoptosome
A	0045333	biological_process	cellular respiration
A	0046872	molecular_function	metal ion binding
A	0070469	cellular_component	respirasome
A	0097193	biological_process	intrinsic apoptotic signaling pathway
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005829	cellular_component	cytosol
B	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
B	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
B	0006915	biological_process	apoptotic process
B	0008635	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
B	0009055	molecular_function	electron transfer activity
B	0020037	molecular_function	heme binding
B	0043293	cellular_component	apoptosome
B	0045333	biological_process	cellular respiration
B	0046872	molecular_function	metal ion binding
B	0070469	cellular_component	respirasome
B	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005758	cellular_component	mitochondrial intermembrane space
C	0005829	cellular_component	cytosol
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
C	0006915	biological_process	apoptotic process
C	0008635	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
C	0009055	molecular_function	electron transfer activity
C	0020037	molecular_function	heme binding
C	0043293	cellular_component	apoptosome
C	0045333	biological_process	cellular respiration
C	0046872	molecular_function	metal ion binding
C	0070469	cellular_component	respirasome
C	0097193	biological_process	intrinsic apoptotic signaling pathway
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005758	cellular_component	mitochondrial intermembrane space
D	0005829	cellular_component	cytosol
D	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
D	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
D	0006915	biological_process	apoptotic process
D	0008635	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
D	0043293	cellular_component	apoptosome
D	0045333	biological_process	cellular respiration
D	0046872	molecular_function	metal ion binding
D	0070469	cellular_component	respirasome
D	0097193	biological_process	intrinsic apoptotic signaling pathway
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005758	cellular_component	mitochondrial intermembrane space
E	0005829	cellular_component	cytosol
E	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
E	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
E	0006915	biological_process	apoptotic process
E	0008635	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
E	0009055	molecular_function	electron transfer activity
E	0020037	molecular_function	heme binding
E	0043293	cellular_component	apoptosome
E	0045333	biological_process	cellular respiration
E	0046872	molecular_function	metal ion binding
E	0070469	cellular_component	respirasome
E	0097193	biological_process	intrinsic apoptotic signaling pathway
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005758	cellular_component	mitochondrial intermembrane space
F	0005829	cellular_component	cytosol
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
F	0006915	biological_process	apoptotic process
F	0008635	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
F	0009055	molecular_function	electron transfer activity
F	0020037	molecular_function	heme binding
F	0043293	cellular_component	apoptosome
F	0045333	biological_process	cellular respiration
F	0046872	molecular_function	metal ion binding
F	0070469	cellular_component	respirasome
F	0097193	biological_process	intrinsic apoptotic signaling pathway
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005758	cellular_component	mitochondrial intermembrane space
G	0005829	cellular_component	cytosol
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
G	0006915	biological_process	apoptotic process
G	0008635	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
G	0009055	molecular_function	electron transfer activity
G	0020037	molecular_function	heme binding
G	0043293	cellular_component	apoptosome
G	0045333	biological_process	cellular respiration
G	0046872	molecular_function	metal ion binding
G	0070469	cellular_component	respirasome
G	0097193	biological_process	intrinsic apoptotic signaling pathway
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005758	cellular_component	mitochondrial intermembrane space
H	0005829	cellular_component	cytosol
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
H	0006915	biological_process	apoptotic process
H	0008635	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
H	0009055	molecular_function	electron transfer activity
H	0020037	molecular_function	heme binding
H	0043293	cellular_component	apoptosome
H	0045333	biological_process	cellular respiration
H	0046872	molecular_function	metal ion binding
H	0070469	cellular_component	respirasome
H	0097193	biological_process	intrinsic apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue HEC A 201

Chain	Residue
A	LYS13
A	TYR46
A	TYR48
A	THR49
A	ASN52
A	TRP59
A	LEU68
A	THR78
A	LYS79
A	MET80
A	LEU94
A	CYS14
A	HOH302
B	GLN16
B	THR28
A	CYS17
A	HIS18
A	THR28
A	GLY29
A	PRO30
A	LEU35
A	THR41

site_id	AC2
Number of Residues	24
Details	binding site for Di-peptide HEM B 201 and CYS B 14

Chain	Residue
A	GLN16
A	CYS17
A	THR28
B	PHE10
B	LYS13
B	SER15
B	GLN16
B	CYS17
B	HIS18
B	THR28
B	GLY29
B	THR40
B	THR41
B	TYR46
B	TYR48
B	THR49
B	ASN52
B	TRP59
B	LEU68
B	THR78
B	LYS79
B	MET80
B	LEU94
B	HOH303

site_id	AC3
Number of Residues	24
Details	binding site for Di-peptide HEM B 201 and CYS B 17

Chain	Residue
A	GLN16
A	CYS17
A	THR28
B	LYS13
B	CYS14
B	SER15
B	GLN16
B	HIS18
B	LYS27
B	THR28
B	GLY29
B	THR40
B	THR41
B	TYR46
B	TYR48
B	THR49
B	ASN52
B	TRP59
B	LEU68
B	THR78
B	LYS79
B	MET80
B	LEU94
B	HOH303

site_id	AC4
Number of Residues	22
Details	binding site for Di-peptide HEM C 201 and CYS C 14

Chain	Residue
C	PHE10
C	LYS13
C	SER15
C	GLN16
C	CYS17
C	HIS18
C	THR28
C	GLY29
C	PRO30
C	ARG38
C	THR41
C	TYR46
C	TYR48
C	THR49
C	ASN52
C	TRP59
C	LEU68
C	THR78
C	LYS79
C	MET80
C	LEU94
C	HOH304

site_id	AC5
Number of Residues	22
Details	binding site for Di-peptide HEM C 201 and CYS C 17

Chain	Residue
C	GLY29
C	PRO30
C	ARG38
C	THR41
C	TYR46
C	TYR48
C	THR49
C	ASN52
C	TRP59
C	LEU68
C	THR78
C	LYS79
C	MET80
C	LEU94
C	HOH304
C	LYS13
C	CYS14
C	SER15
C	GLN16
C	HIS18
C	LYS27
C	THR28

site_id	AC6
Number of Residues	22
Details	binding site for Di-peptide HEM D 201 and CYS D 14

Chain	Residue
D	PHE10
D	LYS13
D	SER15
D	GLN16
D	CYS17
D	HIS18
D	THR28
D	GLY29
D	LEU35
D	ARG38
D	THR40
D	TYR46
D	TYR48
D	THR49
D	ASN52
D	TRP59
D	LEU68
D	THR78
D	LYS79
D	MET80
D	LEU94
D	HOH301

site_id	AC7
Number of Residues	22
Details	binding site for Di-peptide HEM D 201 and CYS D 17

Chain	Residue
D	LYS13
D	CYS14
D	SER15
D	GLN16
D	HIS18
D	LYS27
D	THR28
D	GLY29
D	LEU35
D	ARG38
D	THR40
D	TYR46
D	TYR48
D	THR49
D	ASN52
D	TRP59
D	LEU68
D	THR78
D	LYS79
D	MET80
D	LEU94
D	HOH301

site_id	AC8
Number of Residues	23
Details	binding site for Di-peptide HEM E 201 and CYS E 17

Chain	Residue
E	LYS13
E	CYS14
E	SER15
E	GLN16
E	HIS18
E	LYS27
E	THR28
E	GLY29
E	PRO30
E	LEU35
E	THR40
E	THR41
E	TYR46
E	TYR48
E	THR49
E	ASN52
E	TRP59
E	LEU68
E	THR78
E	LYS79
E	MET80
E	LEU94
E	HOH305

site_id	AC9
Number of Residues	23
Details	binding site for Di-peptide HEM E 201 and CYS E 14

Chain	Residue
E	PHE10
E	LYS13
E	SER15
E	GLN16
E	CYS17
E	HIS18
E	THR28
E	GLY29
E	PRO30
E	LEU35
E	THR40
E	THR41
E	TYR46
E	TYR48
E	THR49
E	ASN52
E	TRP59
E	LEU68
E	THR78
E	LYS79
E	MET80
E	LEU94
E	HOH305

site_id	AD1
Number of Residues	24
Details	binding site for Di-peptide HEM F 201 and CYS F 17

Chain	Residue
F	LYS13
F	CYS14
F	SER15
F	GLN16
F	HIS18
F	LYS27
F	THR28
F	GLY29
F	PRO30
F	LEU35
F	ARG38
F	THR40
F	THR41
F	TYR46
F	TYR48
F	THR49
F	ASN52
F	TRP59
F	LEU68
F	THR78
F	LYS79
F	MET80
F	LEU94
F	HOH302

site_id	AD2
Number of Residues	24
Details	binding site for Di-peptide HEM F 201 and CYS F 14

Chain	Residue
F	PHE10
F	LYS13
F	SER15
F	GLN16
F	CYS17
F	HIS18
F	THR28
F	GLY29
F	PRO30
F	LEU35
F	ARG38
F	THR40
F	THR41
F	TYR46
F	TYR48
F	THR49
F	ASN52
F	TRP59
F	LEU68
F	THR78
F	LYS79
F	MET80
F	LEU94
F	HOH302

site_id	AD3
Number of Residues	22
Details	binding site for Di-peptide HEM G 201 and CYS G 17

Chain	Residue
G	LYS13
G	CYS14
G	SER15
G	GLN16
G	HIS18
G	LYS27
G	THR28
G	GLY29
G	PRO30
G	THR40
G	THR41
G	TYR46
G	TYR48
G	THR49
G	ASN52
G	TRP59
G	LEU68
G	THR78
G	LYS79
G	MET80
G	LEU94
G	HOH304

site_id	AD4
Number of Residues	22
Details	binding site for Di-peptide HEM G 201 and CYS G 14

Chain	Residue
G	PHE10
G	LYS13
G	SER15
G	GLN16
G	CYS17
G	HIS18
G	THR28
G	GLY29
G	PRO30
G	THR40
G	THR41
G	TYR46
G	TYR48
G	THR49
G	ASN52
G	TRP59
G	LEU68
G	THR78
G	LYS79
G	MET80
G	LEU94
G	HOH304

site_id	AD5
Number of Residues	18
Details	binding site for Di-peptide HEM H 201 and CYS H 17

Chain	Residue
H	LYS13
H	CYS14
H	SER15
H	GLN16
H	HIS18
H	LYS27
H	THR28
H	GLY29
H	PRO30
H	TYR46
H	TYR48
H	THR49
H	ASN52
H	TRP59
H	THR78
H	LYS79
H	MET80
H	LEU94

site_id	AD6
Number of Residues	18
Details	binding site for Di-peptide HEM H 201 and CYS H 14

Chain	Residue
H	PHE10
H	LYS13
H	SER15
H	GLN16
H	CYS17
H	HIS18
H	THR28
H	GLY29
H	PRO30
H	TYR46
H	TYR48
H	THR49
H	ASN52
H	TRP59
H	THR78
H	LYS79
H	MET80
H	LEU94

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: covalent => ECO:0000255\|PROSITE-ProRule:PRU00433, ECO:0000269\|PubMed:23150584

Chain	Residue	Details
E	CYS14
E	CYS17
F	CYS14
F	CYS17
G	CYS14
G	CYS17
H	CYS14
H	CYS17
A	CYS17
B	CYS14
B	CYS17
C	CYS14
C	CYS17
D	CYS14
D	CYS17
A	CYS14

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: axial binding residue => ECO:0000255\|PROSITE-ProRule:PRU00433, ECO:0000269\|PubMed:23150584

Chain	Residue	Details
A	HIS18
B	HIS18
C	HIS18
D	HIS18
E	HIS18
F	HIS18
G	HIS18
H	HIS18

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: axial binding residue

Chain	Residue	Details
A	MET80
E	MET80
F	MET80
G	MET80
H	MET80
B	MET80
C	MET80
D	MET80

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: N-acetylglycine => ECO:0000269\|PubMed:13933734

Chain	Residue	Details
A	GLY1
C	GLY1
D	GLY1
E	GLY1
F	GLY1
G	GLY1
H	GLY1
B	GLY1

site_id	SWS_FT_FI5
Number of Residues	16
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P62894

Chain	Residue	Details
E	TYR48
E	TYR97
F	TYR48
F	TYR97
G	TYR48
G	TYR97
H	TYR48
H	TYR97
B	TYR97
C	TYR48
C	TYR97
D	TYR48
D	TYR97
A	TYR48
A	TYR97
B	TYR48

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P62897

Chain	Residue	Details
B	LYS55
C	LYS55
D	LYS55
E	LYS55
F	LYS55
G	LYS55
H	LYS55
A	LYS55

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P62897

Chain	Residue	Details
B	LYS72
C	LYS72
D	LYS72
E	LYS72
F	LYS72
G	LYS72
H	LYS72
A	LYS72

site_id	SWS_FT_FI8
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P62897

Chain	Residue	Details
A	LYS99
B	LYS99
C	LYS99
D	LYS99
E	LYS99
F	LYS99
G	LYS99
H	LYS99

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)