Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6ECJ

Human cytochrome c G41T

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
A	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
A	0009055	molecular_function	electron transfer activity
A	0020037	molecular_function	heme binding
A	0043293	cellular_component	apoptosome
A	0045333	biological_process	cellular respiration
A	0097190	biological_process	apoptotic signaling pathway
A	0097193	biological_process	intrinsic apoptotic signaling pathway
A	0097194	biological_process	execution phase of apoptosis
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005829	cellular_component	cytosol
B	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
B	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
B	0009055	molecular_function	electron transfer activity
B	0020037	molecular_function	heme binding
B	0043293	cellular_component	apoptosome
B	0045333	biological_process	cellular respiration
B	0097190	biological_process	apoptotic signaling pathway
B	0097193	biological_process	intrinsic apoptotic signaling pathway
B	0097194	biological_process	execution phase of apoptosis
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005758	cellular_component	mitochondrial intermembrane space
C	0005829	cellular_component	cytosol
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
C	0009055	molecular_function	electron transfer activity
C	0020037	molecular_function	heme binding
C	0043293	cellular_component	apoptosome
C	0045333	biological_process	cellular respiration
C	0097190	biological_process	apoptotic signaling pathway
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0097194	biological_process	execution phase of apoptosis
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005758	cellular_component	mitochondrial intermembrane space
D	0005829	cellular_component	cytosol
D	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
D	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
D	0043293	cellular_component	apoptosome
D	0045333	biological_process	cellular respiration
D	0097190	biological_process	apoptotic signaling pathway
D	0097193	biological_process	intrinsic apoptotic signaling pathway
D	0097194	biological_process	execution phase of apoptosis
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005758	cellular_component	mitochondrial intermembrane space
E	0005829	cellular_component	cytosol
E	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
E	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
E	0009055	molecular_function	electron transfer activity
E	0020037	molecular_function	heme binding
E	0043293	cellular_component	apoptosome
E	0045333	biological_process	cellular respiration
E	0097190	biological_process	apoptotic signaling pathway
E	0097193	biological_process	intrinsic apoptotic signaling pathway
E	0097194	biological_process	execution phase of apoptosis
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005758	cellular_component	mitochondrial intermembrane space
F	0005829	cellular_component	cytosol
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
F	0009055	molecular_function	electron transfer activity
F	0020037	molecular_function	heme binding
F	0043293	cellular_component	apoptosome
F	0045333	biological_process	cellular respiration
F	0097190	biological_process	apoptotic signaling pathway
F	0097193	biological_process	intrinsic apoptotic signaling pathway
F	0097194	biological_process	execution phase of apoptosis
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005758	cellular_component	mitochondrial intermembrane space
G	0005829	cellular_component	cytosol
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
G	0009055	molecular_function	electron transfer activity
G	0020037	molecular_function	heme binding
G	0043293	cellular_component	apoptosome
G	0045333	biological_process	cellular respiration
G	0097190	biological_process	apoptotic signaling pathway
G	0097193	biological_process	intrinsic apoptotic signaling pathway
G	0097194	biological_process	execution phase of apoptosis
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005758	cellular_component	mitochondrial intermembrane space
H	0005829	cellular_component	cytosol
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
H	0009055	molecular_function	electron transfer activity
H	0020037	molecular_function	heme binding
H	0043293	cellular_component	apoptosome
H	0045333	biological_process	cellular respiration
H	0097190	biological_process	apoptotic signaling pathway
H	0097193	biological_process	intrinsic apoptotic signaling pathway
H	0097194	biological_process	execution phase of apoptosis

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue HEC A 201

Chain	Residue
A	LYS13
A	TYR46
A	TYR48
A	THR49
A	ASN52
A	TRP59
A	LEU68
A	THR78
A	LYS79
A	MET80
A	LEU94
A	CYS14
A	HOH302
B	GLN16
B	THR28
A	CYS17
A	HIS18
A	THR28
A	GLY29
A	PRO30
A	LEU35
A	THR41

site_id	AC2
Number of Residues	24
Details	binding site for Di-peptide HEM B 201 and CYS B 14

Chain	Residue
A	GLN16
A	CYS17
A	THR28
B	PHE10
B	LYS13
B	SER15
B	GLN16
B	CYS17
B	HIS18
B	THR28
B	GLY29
B	THR40
B	THR41
B	TYR46
B	TYR48
B	THR49
B	ASN52
B	TRP59
B	LEU68
B	THR78
B	LYS79
B	MET80
B	LEU94
B	HOH303

site_id	AC3
Number of Residues	24
Details	binding site for Di-peptide HEM B 201 and CYS B 17

Chain	Residue
A	GLN16
A	CYS17
A	THR28
B	LYS13
B	CYS14
B	SER15
B	GLN16
B	HIS18
B	LYS27
B	THR28
B	GLY29
B	THR40
B	THR41
B	TYR46
B	TYR48
B	THR49
B	ASN52
B	TRP59
B	LEU68
B	THR78
B	LYS79
B	MET80
B	LEU94
B	HOH303

site_id	AC4
Number of Residues	22
Details	binding site for Di-peptide HEM C 201 and CYS C 14

Chain	Residue
C	PHE10
C	LYS13
C	SER15
C	GLN16
C	CYS17
C	HIS18
C	THR28
C	GLY29
C	PRO30
C	ARG38
C	THR41
C	TYR46
C	TYR48
C	THR49
C	ASN52
C	TRP59
C	LEU68
C	THR78
C	LYS79
C	MET80
C	LEU94
C	HOH304

site_id	AC5
Number of Residues	22
Details	binding site for Di-peptide HEM C 201 and CYS C 17

Chain	Residue
C	GLY29
C	PRO30
C	ARG38
C	THR41
C	TYR46
C	TYR48
C	THR49
C	ASN52
C	TRP59
C	LEU68
C	THR78
C	LYS79
C	MET80
C	LEU94
C	HOH304
C	LYS13
C	CYS14
C	SER15
C	GLN16
C	HIS18
C	LYS27
C	THR28

site_id	AC6
Number of Residues	22
Details	binding site for Di-peptide HEM D 201 and CYS D 14

Chain	Residue
D	PHE10
D	LYS13
D	SER15
D	GLN16
D	CYS17
D	HIS18
D	THR28
D	GLY29
D	LEU35
D	ARG38
D	THR40
D	TYR46
D	TYR48
D	THR49
D	ASN52
D	TRP59
D	LEU68
D	THR78
D	LYS79
D	MET80
D	LEU94
D	HOH301

site_id	AC7
Number of Residues	22
Details	binding site for Di-peptide HEM D 201 and CYS D 17

Chain	Residue
D	LYS13
D	CYS14
D	SER15
D	GLN16
D	HIS18
D	LYS27
D	THR28
D	GLY29
D	LEU35
D	ARG38
D	THR40
D	TYR46
D	TYR48
D	THR49
D	ASN52
D	TRP59
D	LEU68
D	THR78
D	LYS79
D	MET80
D	LEU94
D	HOH301

site_id	AC8
Number of Residues	23
Details	binding site for Di-peptide HEM E 201 and CYS E 17

Chain	Residue
E	LYS13
E	CYS14
E	SER15
E	GLN16
E	HIS18
E	LYS27
E	THR28
E	GLY29
E	PRO30
E	LEU35
E	THR40
E	THR41
E	TYR46
E	TYR48
E	THR49
E	ASN52
E	TRP59
E	LEU68
E	THR78
E	LYS79
E	MET80
E	LEU94
E	HOH305

site_id	AC9
Number of Residues	23
Details	binding site for Di-peptide HEM E 201 and CYS E 14

Chain	Residue
E	PHE10
E	LYS13
E	SER15
E	GLN16
E	CYS17
E	HIS18
E	THR28
E	GLY29
E	PRO30
E	LEU35
E	THR40
E	THR41
E	TYR46
E	TYR48
E	THR49
E	ASN52
E	TRP59
E	LEU68
E	THR78
E	LYS79
E	MET80
E	LEU94
E	HOH305

site_id	AD1
Number of Residues	24
Details	binding site for Di-peptide HEM F 201 and CYS F 17

Chain	Residue
F	LYS13
F	CYS14
F	SER15
F	GLN16
F	HIS18
F	LYS27
F	THR28
F	GLY29
F	PRO30
F	LEU35
F	ARG38
F	THR40
F	THR41
F	TYR46
F	TYR48
F	THR49
F	ASN52
F	TRP59
F	LEU68
F	THR78
F	LYS79
F	MET80
F	LEU94
F	HOH302

site_id	AD2
Number of Residues	24
Details	binding site for Di-peptide HEM F 201 and CYS F 14

Chain	Residue
F	PHE10
F	LYS13
F	SER15
F	GLN16
F	CYS17
F	HIS18
F	THR28
F	GLY29
F	PRO30
F	LEU35
F	ARG38
F	THR40
F	THR41
F	TYR46
F	TYR48
F	THR49
F	ASN52
F	TRP59
F	LEU68
F	THR78
F	LYS79
F	MET80
F	LEU94
F	HOH302

site_id	AD3
Number of Residues	22
Details	binding site for Di-peptide HEM G 201 and CYS G 17

Chain	Residue
G	LYS13
G	CYS14
G	SER15
G	GLN16
G	HIS18
G	LYS27
G	THR28
G	GLY29
G	PRO30
G	THR40
G	THR41
G	TYR46
G	TYR48
G	THR49
G	ASN52
G	TRP59
G	LEU68
G	THR78
G	LYS79
G	MET80
G	LEU94
G	HOH304

site_id	AD4
Number of Residues	22
Details	binding site for Di-peptide HEM G 201 and CYS G 14

Chain	Residue
G	PHE10
G	LYS13
G	SER15
G	GLN16
G	CYS17
G	HIS18
G	THR28
G	GLY29
G	PRO30
G	THR40
G	THR41
G	TYR46
G	TYR48
G	THR49
G	ASN52
G	TRP59
G	LEU68
G	THR78
G	LYS79
G	MET80
G	LEU94
G	HOH304

site_id	AD5
Number of Residues	18
Details	binding site for Di-peptide HEM H 201 and CYS H 17

Chain	Residue
H	LYS13
H	CYS14
H	SER15
H	GLN16
H	HIS18
H	LYS27
H	THR28
H	GLY29
H	PRO30
H	TYR46
H	TYR48
H	THR49
H	ASN52
H	TRP59
H	THR78
H	LYS79
H	MET80
H	LEU94

site_id	AD6
Number of Residues	18
Details	binding site for Di-peptide HEM H 201 and CYS H 14

Chain	Residue
H	PHE10
H	LYS13
H	SER15
H	GLN16
H	CYS17
H	HIS18
H	THR28
H	GLY29
H	PRO30
H	TYR46
H	TYR48
H	THR49
H	ASN52
H	TRP59
H	THR78
H	LYS79
H	MET80
H	LEU94

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Binding site: {"description":"covalent","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23150584","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23150584","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"N-acetylglycine","evidences":[{"source":"PubMed","id":"13933734","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	16
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P62894","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P62897","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62897","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P62897","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)