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6EAG

CRYSTAL STRUCTURE OF FUSION INHIBITOR JNJ-2408068 IN COMPLEX WITH HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN ESCAPE VARIANT G143S STABILIZED IN THE PREFUSION STATE

Functional Information from GO Data
ChainGOidnamespacecontents
F0019064biological_processfusion of virus membrane with host plasma membrane
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue NHE F 601
ChainResidue
FPHE387
FPHE477
FTYR478
FASP479
FASN496
FILE499

site_idAC2
Number of Residues4
Detailsbinding site for residue SO4 F 602
ChainResidue
FGLN354
FPHE137
FLEU138
FGLY139

site_idAC3
Number of Residues3
Detailsbinding site for residue SO4 F 603
ChainResidue
FASN444
FGLY446
FLYS461

site_idAC4
Number of Residues5
Detailsbinding site for residue TAR F 604
ChainResidue
FLYS315
FTRP341
FALA355
FCYS358
FVAL360

site_idAC5
Number of Residues12
Detailsbinding site for residue 5NK F 605
ChainResidue
FPHE140
FPHE140
FMET396
FASP486
FASP486
FASP486
FGLU487
FPHE488
FPHE488
FPHE488
FASP489
FASP489

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by host furin-like protease => ECO:0000269|PubMed:11493675, ECO:0000269|PubMed:12127793
ChainResidueDetails
FARG109

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Cleavage; by host furin-like protease => ECO:0000269|PubMed:11369882, ECO:0000269|PubMed:12127793
ChainResidueDetails
FARG136

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000269|PubMed:21586636
ChainResidueDetails
FASN27

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000269|PubMed:21586636, ECO:0000269|PubMed:28469033
ChainResidueDetails
FASN70

site_idSWS_FT_FI5
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255
ChainResidueDetails
FASN116
FASN120
FASN126

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000269|PubMed:21586636, ECO:0000269|PubMed:24179220
ChainResidueDetails
FASN500

223166

PDB entries from 2024-07-31

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