6E7B
13-pf 3-start GMPCPP-human alpha1B/beta3 microtubules
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000226 | biological_process | microtubule cytoskeleton organization |
| A | 0000278 | biological_process | mitotic cell cycle |
| A | 0003725 | molecular_function | double-stranded RNA binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005198 | molecular_function | structural molecule activity |
| A | 0005200 | molecular_function | structural constituent of cytoskeleton |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005874 | cellular_component | microtubule |
| A | 0005881 | cellular_component | cytoplasmic microtubule |
| A | 0007017 | biological_process | microtubule-based process |
| A | 0015630 | cellular_component | microtubule cytoskeleton |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030705 | biological_process | cytoskeleton-dependent intracellular transport |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0051301 | biological_process | cell division |
| A | 0071353 | biological_process | cellular response to interleukin-4 |
| B | 0000226 | biological_process | microtubule cytoskeleton organization |
| B | 0000278 | biological_process | mitotic cell cycle |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005200 | molecular_function | structural constituent of cytoskeleton |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005874 | cellular_component | microtubule |
| B | 0007017 | biological_process | microtubule-based process |
| B | 0007411 | biological_process | axon guidance |
| B | 0015630 | cellular_component | microtubule cytoskeleton |
| B | 0030027 | cellular_component | lamellipodium |
| B | 0030175 | cellular_component | filopodium |
| B | 0030182 | biological_process | neuron differentiation |
| B | 0030424 | cellular_component | axon |
| B | 0030425 | cellular_component | dendrite |
| B | 0030426 | cellular_component | growth cone |
| B | 0038007 | biological_process | netrin-activated signaling pathway |
| B | 0042277 | molecular_function | peptide binding |
| B | 0042995 | cellular_component | cell projection |
| B | 0043025 | cellular_component | neuronal cell body |
| B | 0045171 | cellular_component | intercellular bridge |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071944 | cellular_component | cell periphery |
| B | 0072686 | cellular_component | mitotic spindle |
| B | 1990791 | biological_process | dorsal root ganglion development |
| B | 1990890 | molecular_function | netrin receptor binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 501 |
| Chain | Residue |
| B | GLY96 |
| B | THR143 |
| B | G2P502 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | binding site for residue G2P B 502 |
| Chain | Residue |
| B | ASN99 |
| B | SER138 |
| B | GLY141 |
| B | GLY142 |
| B | THR143 |
| B | ASP177 |
| B | ASN204 |
| B | TYR222 |
| B | LEU225 |
| B | ASN226 |
| B | MG501 |
| B | GLY10 |
| B | GLN11 |
| B | CYS12 |
| B | GLN15 |
| B | GLY96 |
| B | GLY98 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 501 |
| Chain | Residue |
| A | GLU71 |
| A | GTP502 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | binding site for residue GTP A 502 |
| Chain | Residue |
| A | GLY10 |
| A | GLN11 |
| A | ALA12 |
| A | GLN15 |
| A | ASP69 |
| A | GLU71 |
| A | ASP98 |
| A | ALA99 |
| A | ALA100 |
| A | ASN101 |
| A | SER140 |
| A | GLY142 |
| A | GLY144 |
| A | THR145 |
| A | ILE171 |
| A | THR179 |
| A | GLU183 |
| A | ASN206 |
| A | TYR224 |
| A | ASN228 |
| A | MG501 |
| B | LYS252 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:34996871 |
| Chain | Residue | Details |
| A | GLU254 | |
| B | GLY142 | |
| B | THR143 | |
| B | GLY144 | |
| B | ASN204 | |
| B | ASN226 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:35482892, ECO:0007744|PDB:7SJ7, ECO:0007744|PDB:7Z6S |
| Chain | Residue | Details |
| A | GLN11 | |
| A | GLU71 | |
| A | SER140 | |
| A | GLY144 | |
| A | THR145 | |
| A | THR179 | |
| A | ASN206 | |
| A | ASN228 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:24906155 |
| Chain | Residue | Details |
| A | LYS40 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|Ref.6 |
| Chain | Residue | Details |
| A | SER48 | |
| A | SER232 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:P68373 |
| Chain | Residue | Details |
| A | TYR282 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0000269|Ref.6 |
| Chain | Residue | Details |
| A | ARG339 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
| Chain | Residue | Details |
| A | LYS326 | |
| A | LYS370 |
