Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6E5S

Crystal structure of holo retinal-bound domain-swapped dimer Q108K:T51D mutant of human Cellular Retinol Binding Protein II

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001523	biological_process	retinoid metabolic process
A	0005501	molecular_function	retinoid binding
A	0005504	molecular_function	fatty acid binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006776	biological_process	vitamin A metabolic process
A	0008289	molecular_function	lipid binding
A	0008544	biological_process	epidermis development
A	0015908	biological_process	fatty acid transport
A	0016918	molecular_function	retinal binding
A	0019841	molecular_function	retinol binding
A	0140104	molecular_function	molecular carrier activity
B	0001523	biological_process	retinoid metabolic process
B	0005501	molecular_function	retinoid binding
B	0005504	molecular_function	fatty acid binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006776	biological_process	vitamin A metabolic process
B	0008289	molecular_function	lipid binding
B	0008544	biological_process	epidermis development
B	0015908	biological_process	fatty acid transport
B	0016918	molecular_function	retinal binding
B	0019841	molecular_function	retinol binding
B	0140104	molecular_function	molecular carrier activity
C	0001523	biological_process	retinoid metabolic process
C	0005501	molecular_function	retinoid binding
C	0005504	molecular_function	fatty acid binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006776	biological_process	vitamin A metabolic process
C	0008289	molecular_function	lipid binding
C	0008544	biological_process	epidermis development
C	0015908	biological_process	fatty acid transport
C	0016918	molecular_function	retinal binding
C	0019841	molecular_function	retinol binding
C	0140104	molecular_function	molecular carrier activity
D	0001523	biological_process	retinoid metabolic process
D	0005501	molecular_function	retinoid binding
D	0005504	molecular_function	fatty acid binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006776	biological_process	vitamin A metabolic process
D	0008289	molecular_function	lipid binding
D	0008544	biological_process	epidermis development
D	0015908	biological_process	fatty acid transport
D	0016918	molecular_function	retinal binding
D	0019841	molecular_function	retinol binding
D	0140104	molecular_function	molecular carrier activity
E	0001523	biological_process	retinoid metabolic process
E	0005501	molecular_function	retinoid binding
E	0005504	molecular_function	fatty acid binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006776	biological_process	vitamin A metabolic process
E	0008289	molecular_function	lipid binding
E	0008544	biological_process	epidermis development
E	0015908	biological_process	fatty acid transport
E	0016918	molecular_function	retinal binding
E	0019841	molecular_function	retinol binding
E	0140104	molecular_function	molecular carrier activity
F	0001523	biological_process	retinoid metabolic process
F	0005501	molecular_function	retinoid binding
F	0005504	molecular_function	fatty acid binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006776	biological_process	vitamin A metabolic process
F	0008289	molecular_function	lipid binding
F	0008544	biological_process	epidermis development
F	0015908	biological_process	fatty acid transport
F	0016918	molecular_function	retinal binding
F	0019841	molecular_function	retinol binding
F	0140104	molecular_function	molecular carrier activity
G	0001523	biological_process	retinoid metabolic process
G	0005501	molecular_function	retinoid binding
G	0005504	molecular_function	fatty acid binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006776	biological_process	vitamin A metabolic process
G	0008289	molecular_function	lipid binding
G	0008544	biological_process	epidermis development
G	0015908	biological_process	fatty acid transport
G	0016918	molecular_function	retinal binding
G	0019841	molecular_function	retinol binding
G	0140104	molecular_function	molecular carrier activity
H	0001523	biological_process	retinoid metabolic process
H	0005501	molecular_function	retinoid binding
H	0005504	molecular_function	fatty acid binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006776	biological_process	vitamin A metabolic process
H	0008289	molecular_function	lipid binding
H	0008544	biological_process	epidermis development
H	0015908	biological_process	fatty acid transport
H	0016918	molecular_function	retinal binding
H	0019841	molecular_function	retinol binding
H	0140104	molecular_function	molecular carrier activity
I	0001523	biological_process	retinoid metabolic process
I	0005501	molecular_function	retinoid binding
I	0005504	molecular_function	fatty acid binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006776	biological_process	vitamin A metabolic process
I	0008289	molecular_function	lipid binding
I	0008544	biological_process	epidermis development
I	0015908	biological_process	fatty acid transport
I	0016918	molecular_function	retinal binding
I	0019841	molecular_function	retinol binding
I	0140104	molecular_function	molecular carrier activity
J	0001523	biological_process	retinoid metabolic process
J	0005501	molecular_function	retinoid binding
J	0005504	molecular_function	fatty acid binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006776	biological_process	vitamin A metabolic process
J	0008289	molecular_function	lipid binding
J	0008544	biological_process	epidermis development
J	0015908	biological_process	fatty acid transport
J	0016918	molecular_function	retinal binding
J	0019841	molecular_function	retinol binding
J	0140104	molecular_function	molecular carrier activity
K	0001523	biological_process	retinoid metabolic process
K	0005501	molecular_function	retinoid binding
K	0005504	molecular_function	fatty acid binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006776	biological_process	vitamin A metabolic process
K	0008289	molecular_function	lipid binding
K	0008544	biological_process	epidermis development
K	0015908	biological_process	fatty acid transport
K	0016918	molecular_function	retinal binding
K	0019841	molecular_function	retinol binding
K	0140104	molecular_function	molecular carrier activity
L	0001523	biological_process	retinoid metabolic process
L	0005501	molecular_function	retinoid binding
L	0005504	molecular_function	fatty acid binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006776	biological_process	vitamin A metabolic process
L	0008289	molecular_function	lipid binding
L	0008544	biological_process	epidermis development
L	0015908	biological_process	fatty acid transport
L	0016918	molecular_function	retinal binding
L	0019841	molecular_function	retinol binding
L	0140104	molecular_function	molecular carrier activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for Di-peptide RET C 201 and LYS C 108

Chain	Residue
A	GLN4
C	LYS107
C	TRP109
C	TYR116
C	LEU117
A	ILE25
A	GLN38
A	LYS40
A	ASP51
C	LEU77
C	VAL92
C	LEU93
C	TRP106

site_id	AC2
Number of Residues	14
Details	binding site for Di-peptide RET G 201 and LYS G 108

Chain	Residue
G	LEU77
G	LEU93
G	TRP106
G	LYS107
G	TRP109
G	TYR116
G	LEU117
G	LEU119
I	GLN4
I	PHE16
I	GLN38
I	LYS40
I	ASP51
I	THR53

site_id	AC3
Number of Residues	12
Details	binding site for Di-peptide RET H 201 and LYS H 108

Chain	Residue
F	GLN4
F	PHE16
F	GLN38
F	LYS40
F	ASP51
F	THR53
H	LEU77
H	LEU93
H	TRP106
H	LYS107
H	TRP109
H	TYR116

site_id	AC4
Number of Residues	16
Details	binding site for Di-peptide RET I 201 and LYS I 108

Chain	Residue
G	GLN4
G	PHE16
G	MET20
G	ILE25
G	GLN38
G	LYS40
G	ASP51
G	SER55
G	HOH333
I	LEU77
I	LEU93
I	TRP106
I	LYS107
I	TRP109
I	TYR116
I	LEU117

site_id	AC5
Number of Residues	15
Details	binding site for Di-peptide RET J 201 and LYS J 108

Chain	Residue
B	GLN4
B	PHE16
B	ILE25
B	GLN38
B	LYS40
B	ASP51
B	SER55
J	LEU77
J	LEU93
J	TRP106
J	LYS107
J	TRP109
J	LEU115
J	TYR116
J	LEU117

site_id	AC6
Number of Residues	15
Details	binding site for Di-peptide RET K 201 and LYS K 108

Chain	Residue
D	GLN4
D	PHE16
D	TYR19
D	MET20
D	ILE25
D	GLN38
D	LYS40
D	ASP51
D	HOH208
K	LEU77
K	LEU93
K	TRP106
K	LYS107
K	TRP109
K	TYR116

site_id	AC7
Number of Residues	11
Details	binding site for Di-peptide RET L 201 and LYS L 108

Chain	Residue
E	GLN4
E	GLN38
E	LYS40
E	ASP51
L	LEU77
L	LEU93
L	TRP106
L	LYS107
L	TRP109
L	TYR116
L	LEU117

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. GTWeMesNeNFEgYMKAL

Chain	Residue	Details
A	GLY6-LEU23

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18076076","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)