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6E46

CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) in complex with ferrous heme and tryptophan

Functional Information from GO Data
ChainGOidnamespacecontents
A0002376biological_processimmune system process
A0002666biological_processpositive regulation of T cell tolerance induction
A0002678biological_processpositive regulation of chronic inflammatory response
A0002830biological_processpositive regulation of type 2 immune response
A0004833molecular_functiontryptophan 2,3-dioxygenase activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006569biological_processL-tryptophan catabolic process
A0006954biological_processinflammatory response
A0007565biological_processfemale pregnancy
A0009055molecular_functionelectron transfer activity
A0016491molecular_functionoxidoreductase activity
A0019441biological_processL-tryptophan catabolic process to kynurenine
A0019805biological_processquinolinate biosynthetic process
A0020037molecular_functionheme binding
A0030485cellular_componentsmooth muscle contractile fiber
A0032421cellular_componentstereocilium bundle
A0032496biological_processresponse to lipopolysaccharide
A0032693biological_processnegative regulation of interleukin-10 production
A0032735biological_processpositive regulation of interleukin-12 production
A0033555biological_processmulticellular organismal response to stress
A0033754molecular_functionindoleamine 2,3-dioxygenase activity
A0034276biological_processkynurenic acid biosynthetic process
A0034354biological_process'de novo' NAD+ biosynthetic process from L-tryptophan
A0036269biological_processswimming behavior
A0042098biological_processT cell proliferation
A0042130biological_processnegative regulation of T cell proliferation
A0043065biological_processpositive regulation of apoptotic process
A0046006biological_processregulation of activated T cell proliferation
A0046872molecular_functionmetal ion binding
A0051213molecular_functiondioxygenase activity
A0070233biological_processnegative regulation of T cell apoptotic process
A0070234biological_processpositive regulation of T cell apoptotic process
B0002376biological_processimmune system process
B0002666biological_processpositive regulation of T cell tolerance induction
B0002678biological_processpositive regulation of chronic inflammatory response
B0002830biological_processpositive regulation of type 2 immune response
B0004833molecular_functiontryptophan 2,3-dioxygenase activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006569biological_processL-tryptophan catabolic process
B0006954biological_processinflammatory response
B0007565biological_processfemale pregnancy
B0009055molecular_functionelectron transfer activity
B0016491molecular_functionoxidoreductase activity
B0019441biological_processL-tryptophan catabolic process to kynurenine
B0019805biological_processquinolinate biosynthetic process
B0020037molecular_functionheme binding
B0030485cellular_componentsmooth muscle contractile fiber
B0032421cellular_componentstereocilium bundle
B0032496biological_processresponse to lipopolysaccharide
B0032693biological_processnegative regulation of interleukin-10 production
B0032735biological_processpositive regulation of interleukin-12 production
B0033555biological_processmulticellular organismal response to stress
B0033754molecular_functionindoleamine 2,3-dioxygenase activity
B0034276biological_processkynurenic acid biosynthetic process
B0034354biological_process'de novo' NAD+ biosynthetic process from L-tryptophan
B0036269biological_processswimming behavior
B0042098biological_processT cell proliferation
B0042130biological_processnegative regulation of T cell proliferation
B0043065biological_processpositive regulation of apoptotic process
B0046006biological_processregulation of activated T cell proliferation
B0046872molecular_functionmetal ion binding
B0051213molecular_functiondioxygenase activity
B0070233biological_processnegative regulation of T cell apoptotic process
B0070234biological_processpositive regulation of T cell apoptotic process
C0002376biological_processimmune system process
C0002666biological_processpositive regulation of T cell tolerance induction
C0002678biological_processpositive regulation of chronic inflammatory response
C0002830biological_processpositive regulation of type 2 immune response
C0004833molecular_functiontryptophan 2,3-dioxygenase activity
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006569biological_processL-tryptophan catabolic process
C0006954biological_processinflammatory response
C0007565biological_processfemale pregnancy
C0009055molecular_functionelectron transfer activity
C0016491molecular_functionoxidoreductase activity
C0019441biological_processL-tryptophan catabolic process to kynurenine
C0019805biological_processquinolinate biosynthetic process
C0020037molecular_functionheme binding
C0030485cellular_componentsmooth muscle contractile fiber
C0032421cellular_componentstereocilium bundle
C0032496biological_processresponse to lipopolysaccharide
C0032693biological_processnegative regulation of interleukin-10 production
C0032735biological_processpositive regulation of interleukin-12 production
C0033555biological_processmulticellular organismal response to stress
C0033754molecular_functionindoleamine 2,3-dioxygenase activity
C0034276biological_processkynurenic acid biosynthetic process
C0034354biological_process'de novo' NAD+ biosynthetic process from L-tryptophan
C0036269biological_processswimming behavior
C0042098biological_processT cell proliferation
C0042130biological_processnegative regulation of T cell proliferation
C0043065biological_processpositive regulation of apoptotic process
C0046006biological_processregulation of activated T cell proliferation
C0046872molecular_functionmetal ion binding
C0051213molecular_functiondioxygenase activity
C0070233biological_processnegative regulation of T cell apoptotic process
C0070234biological_processpositive regulation of T cell apoptotic process
D0002376biological_processimmune system process
D0002666biological_processpositive regulation of T cell tolerance induction
D0002678biological_processpositive regulation of chronic inflammatory response
D0002830biological_processpositive regulation of type 2 immune response
D0004833molecular_functiontryptophan 2,3-dioxygenase activity
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006569biological_processL-tryptophan catabolic process
D0006954biological_processinflammatory response
D0007565biological_processfemale pregnancy
D0009055molecular_functionelectron transfer activity
D0016491molecular_functionoxidoreductase activity
D0019441biological_processL-tryptophan catabolic process to kynurenine
D0019805biological_processquinolinate biosynthetic process
D0020037molecular_functionheme binding
D0030485cellular_componentsmooth muscle contractile fiber
D0032421cellular_componentstereocilium bundle
D0032496biological_processresponse to lipopolysaccharide
D0032693biological_processnegative regulation of interleukin-10 production
D0032735biological_processpositive regulation of interleukin-12 production
D0033555biological_processmulticellular organismal response to stress
D0033754molecular_functionindoleamine 2,3-dioxygenase activity
D0034276biological_processkynurenic acid biosynthetic process
D0034354biological_process'de novo' NAD+ biosynthetic process from L-tryptophan
D0036269biological_processswimming behavior
D0042098biological_processT cell proliferation
D0042130biological_processnegative regulation of T cell proliferation
D0043065biological_processpositive regulation of apoptotic process
D0046006biological_processregulation of activated T cell proliferation
D0046872molecular_functionmetal ion binding
D0051213molecular_functiondioxygenase activity
D0070233biological_processnegative regulation of T cell apoptotic process
D0070234biological_processpositive regulation of T cell apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues25
Detailsbinding site for residue HEM A 501
ChainResidue
ATYR126
APHE270
AARG343
AHIS346
AILE349
AVAL350
ATYR353
AILE354
AGLY378
AGLY380
AGLY381
APHE163
ATHR382
APHE387
AVAL391
ATRP502
AHOH612
AHOH643
ASER167
AVAL170
APHE214
APHE226
ASER263
AALA264
AGLY265

site_idAC2
Number of Residues13
Detailsbinding site for residue TRP A 502
ChainResidue
ATYR126
APHE163
APHE226
AARG231
ALEU234
AGLY262
ASER263
AALA264
AILE354
AGLY378
ATHR379
AHEM501
AHOH605

site_idAC3
Number of Residues25
Detailsbinding site for residue HEM B 501
ChainResidue
BPHE163
BSER167
BVAL170
BPHE214
BPHE226
BSER263
BALA264
BGLY265
BPHE270
BPHE291
BARG343
BHIS346
BILE349
BVAL350
BILE354
BGLY378
BTHR379
BGLY380
BGLY381
BTHR382
BVAL391
BTRP502
BHOH617
BHOH671
BHOH679

site_idAC4
Number of Residues13
Detailsbinding site for residue TRP B 502
ChainResidue
BTYR126
BPHE163
BPHE226
BARG231
BLEU234
BGLY262
BSER263
BALA264
BILE354
BGLY378
BTHR379
BHEM501
BHOH671

site_idAC5
Number of Residues23
Detailsbinding site for residue HEM C 501
ChainResidue
CTYR126
CPHE163
CSER167
CVAL170
CPHE214
CPHE226
CSER263
CALA264
CGLY265
CPHE270
CARG343
CHIS346
CILE349
CVAL350
CILE354
CGLY378
CGLY380
CGLY381
CTHR382
CPHE387
CVAL391
CTRP503
CHOH648

site_idAC6
Number of Residues4
Detailsbinding site for residue PO4 C 502
ChainResidue
BGLU60
BARG100
CPRO33
CASP34

site_idAC7
Number of Residues12
Detailsbinding site for residue TRP C 503
ChainResidue
CTYR126
CPHE163
CPHE226
CARG231
CLEU234
CGLY262
CSER263
CALA264
CILE354
CGLY378
CTHR379
CHEM501

site_idAC8
Number of Residues24
Detailsbinding site for residue HEM D 501
ChainResidue
DPHE163
DSER167
DVAL170
DPHE214
DILE217
DPHE226
DSER263
DALA264
DGLY265
DPHE270
DARG343
DHIS346
DILE349
DTYR353
DILE354
DGLY378
DGLY380
DGLY381
DTHR382
DVAL391
DTRP503
DHOH613
DHOH623
DHOH660

site_idAC9
Number of Residues3
Detailsbinding site for residue PO4 D 502
ChainResidue
DTYR145
DLYS161
DHIS220

site_idAD1
Number of Residues13
Detailsbinding site for residue TRP D 503
ChainResidue
DTYR126
DPHE163
DPHE226
DARG231
DLEU234
DGLY262
DSER263
DALA264
DILE354
DGLY378
DTHR379
DHEM501
DHOH623

Functional Information from PROSITE/UniProt
site_idPS00876
Number of Residues11
DetailsIDO_1 Indoleamine 2,3-dioxygenase signature 1. GGSAGQSSvfQ
ChainResidueDetails
AGLY261-GLN271

site_idPS00877
Number of Residues14
DetailsIDO_2 Indoleamine 2,3-dioxygenase signature 2. FLQDMrrYMppaHR
ChainResidueDetails
APHE291-ARG304

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: proximal binding residue => ECO:0000269|PubMed:16477023, ECO:0000269|PubMed:25313323, ECO:0007744|PDB:2D0T, ECO:0007744|PDB:2D0U, ECO:0007744|PDB:4PK5, ECO:0007744|PDB:4PK6
ChainResidueDetails
AHIS346
BHIS346
CHIS346
DHIS346

237735

PDB entries from 2025-06-18

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