6E37

O-GlcNAc Transferase in complex with covalent inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006493	biological_process	protein O-linked glycosylation
A	0016757	molecular_function	glycosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	binding site for residue HQV A 1101

Chain	Residue
A	HIS498
A	LYS842
A	LEU866
A	VAL895
A	ALA896
A	LYS898
A	HIS901
A	ARG904
A	CYS917
A	HIS920
A	THR921
A	PRO559
A	THR922
A	ASP925
A	HOH1238
A	HOH1251
A	HOH1310
B	THR18
B	VAL20
B	SER21
B	HOH102
A	THR560
A	LEU563
A	LEU653
A	PRO656
A	PHE694
A	GLN839
A	TYR841

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by CDK1 => ECO:0000269|PubMed:7592773

Chain	Residue	Details
B	THR18

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:23103939, ECO:0007744|PDB:4GYW

Chain	Residue	Details
A	ASP968
A	LYS1022
A	ILE1027
A	GLU965

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by AMPK => ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:37541260

Chain	Residue	Details
A	MET570

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: O-linked (GlcNAc) serine; by autocatalysis => ECO:0000269|PubMed:27713473

Chain	Residue	Details
A	GLU515

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