6E1M
Structure of AtTPC1(DDE) reconstituted in saposin A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000325 | cellular_component | plant-type vacuole |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005245 | molecular_function | voltage-gated calcium channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005773 | cellular_component | vacuole |
| A | 0005774 | cellular_component | vacuolar membrane |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0009845 | biological_process | seed germination |
| A | 0010119 | biological_process | regulation of stomatal movement |
| A | 0016020 | cellular_component | membrane |
| A | 0019722 | biological_process | calcium-mediated signaling |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0050896 | biological_process | response to stimulus |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0080141 | biological_process | regulation of jasmonic acid biosynthetic process |
| B | 0000325 | cellular_component | plant-type vacuole |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005245 | molecular_function | voltage-gated calcium channel activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005773 | cellular_component | vacuole |
| B | 0005774 | cellular_component | vacuolar membrane |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006816 | biological_process | calcium ion transport |
| B | 0009845 | biological_process | seed germination |
| B | 0010119 | biological_process | regulation of stomatal movement |
| B | 0016020 | cellular_component | membrane |
| B | 0019722 | biological_process | calcium-mediated signaling |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0034702 | cellular_component | monoatomic ion channel complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0050896 | biological_process | response to stimulus |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0080141 | biological_process | regulation of jasmonic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue CA A 801 |
| Chain | Residue |
| A | ASN631 |
| B | ASN631 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue CA A 803 |
| Chain | Residue |
| A | ASP606 |
| B | ASP606 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue CA A 804 |
| Chain | Residue |
| A | GLU374 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CA A 805 |
| Chain | Residue |
| A | ASP335 |
| A | ASN339 |
| A | GLU341 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue CA B 801 |
| Chain | Residue |
| B | GLU374 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 802 |
| Chain | Residue |
| B | ASP335 |
| B | ASP337 |
| B | ASN339 |
| B | GLU341 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S1 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU72-TRP92 | |
| B | LEU72-TRP92 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 266 |
| Details | TOPO_DOM: Vacuolar => ECO:0000255 |
| Chain | Residue | Details |
| A | CYS93-SER120 | |
| B | ASP180 | |
| B | ASN240-LEU245 | |
| B | LEU261-SER282 | |
| B | GLU450-GLN465 | |
| B | GLU520-GLN528 | |
| B | TYR579-ASP615 | |
| B | ASN631-TYR651 | |
| A | ASP180 | |
| A | ASN240-LEU245 | |
| A | LEU261-SER282 | |
| A | GLU450-GLN465 | |
| A | GLU520-GLN528 | |
| A | TYR579-ASP615 | |
| A | ASN631-TYR651 | |
| B | CYS93-SER120 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE121-TYR141 | |
| B | ILE121-TYR141 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 478 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU142-ALA158 | |
| B | GLY487-ARG498 | |
| B | ASN547-THR557 | |
| B | GLU673-THR733 | |
| A | ARG200-ASN218 | |
| A | VAL304-ARG428 | |
| A | GLY487-ARG498 | |
| A | ASN547-THR557 | |
| A | GLU673-THR733 | |
| B | GLU142-ALA158 | |
| B | ARG200-ASN218 | |
| B | VAL304-ARG428 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | CYS159-PHE179 | |
| B | CYS159-PHE179 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE181-ILE199 | |
| B | PHE181-ILE199 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE219-GLU239 | |
| B | ILE219-GLU239 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 28 |
| Details | INTRAMEM: Pore-forming; Name=Pore-forming 1 |
| Chain | Residue | Details |
| A | THR246-ILE260 | |
| B | THR246-ILE260 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL283-VAL303 | |
| B | VAL283-VAL303 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | SER429-VAL449 | |
| B | SER429-VAL449 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL466-TYR486 | |
| B | VAL466-TYR486 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE499-ASP519 | |
| B | PHE499-ASP519 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 34 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | TRP529-MET546 | |
| B | TRP529-MET546 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE558-ILE578 | |
| B | PHE558-ILE578 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 28 |
| Details | INTRAMEM: Pore-forming; Name=Pore-forming 2 |
| Chain | Residue | Details |
| A | TYR616-GLY630 | |
| B | TYR616-GLY630 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE652-LEU672 | |
| B | PHE652-LEU672 |
