6E13

Pseudomonas putida PqqB with a non-physiological zinc at the active site binds the substrate mimic, 5-cysteinyl-3,4-dihydroxyphenylalanine (5-Cys-DOPA), non-specifically but supports the proposed function of the enzyme in pyrroloquinoline quinone biosynthesis.

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Functional Information from GO Data

ChainGOidnamespacecontents
A0018189biological_processpyrroloquinoline quinone biosynthetic process
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC14binding site for residue ZN A 401
ChainResidue
ACYS19
ACYS21
ACYS24
AASN272

AC23binding site for residue ZN A 402
ChainResidue
AHIS93
AHIS269
AHOH528

AC35binding site for residue CL A 403
ChainResidue
AGLN90
AILE91
APRO166
AHKS404
AHOH520

AC415binding site for residue HKS A 404
ChainResidue
AALA10
AALA11
AGLN16
AARG77
AGLN90
AASP92
AARG101
ATRP131
APRO167
AMET229
AHIS269
AASN271
AASN272
ACL403
AHOH520

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
HKS_6e13_A_404153-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}-5-hydroxy-L-tyrosine binding site
ChainResidueligand
AALA10-GLY12HKS: 3-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}-5-hydroxy-L-tyrosine
AGLN16HKS: 3-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}-5-hydroxy-L-tyrosine
AGLN90HKS: 3-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}-5-hydroxy-L-tyrosine
AASP92HKS: 3-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}-5-hydroxy-L-tyrosine
APRO166-PRO167HKS: 3-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}-5-hydroxy-L-tyrosine
AMET229HKS: 3-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}-5-hydroxy-L-tyrosine
AMET242HKS: 3-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}-5-hydroxy-L-tyrosine
AHIS244HKS: 3-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}-5-hydroxy-L-tyrosine
AHIS269HKS: 3-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}-5-hydroxy-L-tyrosine
AASN271-THR273HKS: 3-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}-5-hydroxy-L-tyrosine

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
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Catalytic Information from CSA

site_idNumber of ResiduesDetails