6E08

Crystal structure of G6PD in complex with structural NADP

Replaces:  5VFL

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
L	0005515	molecular_function	protein binding
L	0005536	molecular_function	glucose binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006006	biological_process	glucose metabolic process
L	0006098	biological_process	pentose-phosphate shunt
L	0006629	biological_process	lipid metabolic process
L	0006695	biological_process	cholesterol biosynthetic process
L	0006739	biological_process	NADP metabolic process
L	0006740	biological_process	NADPH regeneration
L	0006749	biological_process	glutathione metabolic process
L	0009051	biological_process	pentose-phosphate shunt, oxidative branch
L	0009898	cellular_component	cytoplasmic side of plasma membrane
L	0010041	biological_process	response to iron(III) ion
L	0010734	biological_process	negative regulation of protein glutathionylation
L	0014070	biological_process	response to organic cyclic compound
L	0016020	cellular_component	membrane
L	0016491	molecular_function	oxidoreductase activity
L	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
L	0019322	biological_process	pentose biosynthetic process
L	0021762	biological_process	substantia nigra development
L	0030246	molecular_function	carbohydrate binding
L	0032094	biological_process	response to food
L	0034451	cellular_component	centriolar satellite
L	0034599	biological_process	cellular response to oxidative stress
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0043231	cellular_component	intracellular membrane-bounded organelle
L	0043249	biological_process	erythrocyte maturation
L	0043523	biological_process	regulation of neuron apoptotic process
L	0045471	biological_process	response to ethanol
L	0046390	biological_process	ribose phosphate biosynthetic process
L	0050661	molecular_function	NADP binding
L	0051156	biological_process	glucose 6-phosphate metabolic process
L	0061052	biological_process	negative regulation of cell growth involved in cardiac muscle cell development
L	0070062	cellular_component	extracellular exosome
L	1904879	biological_process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
L	2000378	biological_process	negative regulation of reactive oxygen species metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	binding site for residue NAP L 601

Chain	Residue
L	LYS238
L	ASP493
L	MET496
L	PHE501
L	TYR503
L	TYR507
L	TRP509
L	HOH710
L	HOH716
L	HOH725
L	HOH736
L	LYS366
L	HOH756
L	HOH759
L	HOH766
L	HOH793
L	HOH831
L	HOH835
L	ARG370
L	ARG393
L	TYR401
L	LYS403
L	ASP421
L	THR423
L	ARG487

---

site_id	AC2
Number of Residues	6
Details	binding site for residue GOL L 602

Chain	Residue
L	ARG219
L	ARG227
L	ASP350
L	ASP375
L	HOH825
L	HOH980

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL L 603

Chain	Residue
L	LYS293
L	CYS294
L	ILE295
L	GLU345
L	ARG463
L	HOH749
L	HOH938

---

site_id	AC4
Number of Residues	7
Details	binding site for residue GOL L 604

Chain	Residue
L	LYS171
L	HIS201
L	PHE237
L	GLU239
L	ASP258
L	VAL259
L	HIS263

---

site_id	AC5
Number of Residues	2
Details	binding site for residue GOL L 605

Chain	Residue
L	TYR343
L	HOH727

---

site_id	AC6
Number of Residues	2
Details	binding site for residue GOL L 606

Chain	Residue
L	LYS497
L	ARG498

---

Functional Information from PROSITE/UniProt

site_id	PS00069
Number of Residues	7
Details	G6P_DEHYDROGENASE Glucose-6-phosphate dehydrogenase active site. DHYLGKE

Chain	Residue	Details
L	ASP200-GLU206

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P11411

Chain	Residue	Details
L	HIS263

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:10745013, ECO:0000269|PubMed:15858258, ECO:0007744|PDB:1QKI, ECO:0007744|PDB:2BH9

Chain	Residue	Details
L	GLY38
L	ARG487
L	TYR503
L	TRP509
L	ARG72
L	TYR147
L	ARG357
L	LYS366
L	ARG370
L	ARG393
L	TYR401
L	ASP421

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:15858258, ECO:0007744|PDB:2BH9

Chain	Residue	Details
L	LYS171
L	HIS201
L	GLU239
L	ASP258

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:15858258, ECO:0007744|PDB:2BHL

Chain	Residue	Details
L	LYS360
L	ARG365
L	GLN395

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:7857286, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378

Chain	Residue	Details
L	ALA2

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
L	SER8

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
L	THR10

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
L	LYS89
L	LYS432
L	LYS497

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
L	LYS171

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:24769394, ECO:0007744|PubMed:19608861

Chain	Residue	Details
L	LYS403

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
L	TYR503

---