6DZH
HRAS G13D bound to GDP (H13GDP)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0007165 | biological_process | signal transduction |
| A | 0016020 | cellular_component | membrane |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0007165 | biological_process | signal transduction |
| B | 0016020 | cellular_component | membrane |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005525 | molecular_function | GTP binding |
| C | 0007165 | biological_process | signal transduction |
| C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue GDP A 201 |
| Chain | Residue |
| A | ASP13 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | LEU120 |
| A | SER145 |
| A | ALA146 |
| A | LYS147 |
| A | MG202 |
| A | HOH313 |
| A | HOH321 |
| A | VAL14 |
| A | HOH355 |
| A | HOH365 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | VAL29 |
| A | GLU31 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | SER17 |
| A | GDP201 |
| A | HOH321 |
| A | HOH325 |
| A | HOH330 |
| A | HOH355 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 203 |
| Chain | Residue |
| A | ASN85 |
| A | ALA122 |
| C | PHE90 |
| C | GLU91 |
| C | HIS94 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | binding site for residue GDP B 201 |
| Chain | Residue |
| A | ARG41 |
| B | ASP13 |
| B | VAL14 |
| B | GLY15 |
| B | LYS16 |
| B | SER17 |
| B | ALA18 |
| B | PHE28 |
| B | ASP30 |
| B | GLU31 |
| B | ASP33 |
| B | ASN116 |
| B | LYS117 |
| B | ASP119 |
| B | LEU120 |
| B | SER145 |
| B | ALA146 |
| B | LYS147 |
| B | MG203 |
| B | CA204 |
| B | HOH309 |
| B | HOH351 |
| B | HOH352 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue MG B 202 |
| Chain | Residue |
| A | TYR32 |
| B | GLY138 |
| B | HOH319 |
| B | HOH321 |
| B | HOH322 |
| B | HOH346 |
| B | HOH360 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 203 |
| Chain | Residue |
| B | SER17 |
| B | ASP33 |
| B | GDP201 |
| B | HOH309 |
| B | HOH355 |
| B | HOH358 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 204 |
| Chain | Residue |
| A | HOH309 |
| A | HOH339 |
| B | ASP13 |
| B | ASP33 |
| B | GDP201 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue DTT B 205 |
| Chain | Residue |
| A | THR124 |
| A | GLU126 |
| A | GLN129 |
| A | HOH371 |
| B | THR87 |
| B | THR124 |
| B | GLN129 |
| B | HOH306 |
| C | HOH309 |
| site_id | AC9 |
| Number of Residues | 20 |
| Details | binding site for residue GDP C 201 |
| Chain | Residue |
| C | HOH316 |
| C | HOH327 |
| C | HOH348 |
| C | ASP13 |
| C | VAL14 |
| C | GLY15 |
| C | LYS16 |
| C | SER17 |
| C | ALA18 |
| C | PHE28 |
| C | ASN116 |
| C | LYS117 |
| C | ASP119 |
| C | LEU120 |
| C | SER145 |
| C | ALA146 |
| C | LYS147 |
| C | MG202 |
| C | HOH302 |
| C | HOH314 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 202 |
| Chain | Residue |
| C | SER17 |
| C | GDP201 |
| C | HOH314 |
| C | HOH348 |
| C | HOH366 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue CA C 203 |
| Chain | Residue |
| C | GLU3 |
| C | GLU76 |
| C | HOH341 |
| C | HOH375 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16698776","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N-acetylmethionine; in GTPase HRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N-acetylthreonine; in GTPase HRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"9020151","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9632667","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region"} |
| Chain | Residue | Details |
